Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome

Cowley, Hugh; Heney, David; Gearing, A. J. H.; Hemingway, Ian; Webster, Nigel R.

doi:10.1097/00003246-199404000-00022

Cited by 171 publications

(115 citation statements)

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“…The highest serum concentrations of both various cytokines as well as adhesion molecules have been reported in patients with septic shock and fatal outcome [4,7,8]. In the present study nonsurvivors showed higher serum levels of all the three adhesion molecules compared with those who did survive, but the differences did not reach statistical signi®cance.…”

Section: Discussioncontrasting

confidence: 75%

“…It has also been proposed that the release of E-selectin is related to the degree of vascular or endothelial injury caused by the sepsis [4]. Increased plasma and serum levels of VCAM-1 and ICAM-1 have been shown in bacteremic patients [7,8]. E-selectin as well as ICAM-1 has also been found to be associated with multiple organ dysfunction, septic shock and death [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Also associations have been found between increased concentrations of adhesion molecules and either multiple organ dysfunction, disease severity or death [4,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Adhesion molecules (E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)) in sera from patients withStaphylococcus aureusbacteraemia with or without endocarditis

Söderquist

Vikerfors

1999

Clinical and Experimental Immunology

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SUMMARYThe aim of this prospective study was to evaluate if patients with endocarditis display a more extensive endothelial activation than those with bacteraemia but without endocarditis. Sixty-®ve patients with blood culture-veri®ed Staphylococcus aureus bacteraemia were included and serum samples collected on admission were analysed by enzyme immunoassays. Elevated serum concentrations of adhesion molecules were found in most of the patients with S. aureus bacteraemia. Patients with endocarditis (n 15) showed signi®cantly higher serum E-selectin (median 156 ng/ml) and VCAM-1 (median 1745 ng/ml) concentrations compared with those with S. aureus bacteraemia but without endocarditis (80 ng/ml and 1172 ng/ml, respectively; P 0´01 and P 0´003). No signi®cant difference was found between the groups concerning ICAM-1 (median 451 ng/ml versus 522 ng/ml). In addition, serum tumour necrosis factor-alpha (TNF-a) concentrations were signi®cantly correlated (P < 0´002) to serum levels of E-selectin, ICAM-1 and VCAM-1.

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

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Adhesion molecules (E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)) in sera from patients withStaphylococcus aureusbacteraemia with or without endocarditis

Söderquist

Vikerfors

1999

Clinical and Experimental Immunology

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“…Several inflammatory cytokines, such as IL1b, IL6, and TNF-a, can suppress, via direct or indirect pathways, the thyroid function at different levels (41, 42). In sepsis, the increase in the production of pro-inflammatory cytokines is more pronounced than that in other types of critical illness (43,44). In this respect, baseline levels of thyroid hormones, including T 4 , T 3 , and TSH, can be substantially lower in septic patients than in non-septic patients with critical illness of similar severity (45).…”

Section: Discussionmentioning

confidence: 99%

Association between thyroid function tests at baseline and the outcome of patients with sepsis or septic shock: a systematic review

Angelousi

Karageorgopoulos

Kapaskelis

et al. 2011

European Journal of Endocrinology

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Introduction: The severity of critical illness is associated with various patterns of thyroid hormone abnormalities. We sought to evaluate whether the outcome of patients with, specifically, sepsis or septic shock is associated with the thyroid function tests evaluated at diagnosis or admission in the intensive care unit (ICU). Methods: We performed a systematic review of relevant studies by searching PubMed. Results: We included nine studies that all had a prospective cohort design. Seven involved children or neonates, and two involved adults. Mortality was the outcome evaluated in eight studies, while the length of ICU stay was evaluated in the remaining study. In univariate analysis, six of the nine included studies showed that either, free or total, triiodothyronine or thyroxine was lower in the group of patients with sepsis or septic shock who had unfavorable outcome than in those who had favorable outcome. Two other studies showed higher TSH values in the group of patients with unfavorable outcome. No significant relevant findings were observed in the remaining study. Regarding the correlation of sepsis prognostic scoring systems with thyroid function tests, the three studies that provided specific relevant data showed variable findings. Discussion: Most of the relevant studies identified favor the concept that decreased thyroid function at baseline might be associated with a worse outcome of patients with sepsis or septic shock. Although these findings are not consistent, the role of thyroid function in affecting or merely predicting the outcome of sepsis or septic shock merits further investigation.

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“…16 The endothelial ligand ICAM-1 is a counterpart of CD11b as an inducible transmembrane protein of the PMN migration process. The level of its soluble form (sICAM-1) is proportional to the expression of ICAM-1 on the cell membranes, and particularly on the endothelial cells, 17 and this parameter can therefore be used to assess endothelial activation. Nevertheless, the result was unhelpful in that the plasma concentration of this protein displayed a very large dispersion.…”

Section: Discussionmentioning

confidence: 99%

Ischemic limb preconditioning downregulates systemic inflammatory activation

Szabó

Varga

Keresztes

et al. 2008

Journal Orthopaedic Research

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We examined local and systemic antiinflammatory consequences of ischemic preconditioning (IPC) in a rat model of limb ischemia-reperfusion (I-R) by characterizing the leukocyte-endothelial interactions in the periosteum and the expression of adhesion molecules playing a role in leukocyte-mediated inflammatory processes. IPC induction (2 cycles of 10 min of complete limb ischemia and 10 min of reperfusion) was followed by 60 min of ischemia/180 min of reperfusion or sham-operation. Data were compared with those on animals subjected to I-R and sham-operation. Neutrophil leukocyte-endothelial cell interactions (intravital videomicroscopy), intravascular neutrophil activation (CD11b expression changes by flow cytometry), and soluble and tissue intercellular adhesion molecule-1 (ICAM-1; ELISA and immunohistochemistry, respectively) expressions were assessed. I-R induced enhanced leukocyte rolling and adherence in the periosteal postcapillary venules after 120 and 180 min of reperfusion. This was associated with a significantly enhanced CD11b expression (by $80% and 72%, respectively) and moderately increased soluble and periosteal ICAM-1 expressions. IPC prevented the I-R-induced increases in leukocyte adherence and CD11b expression without influencing the soluble and tissue ICAM-1 levels. The results show that limb IPC exerts not only local, but distant antiinflammatory effects through significant modulation of neutrophil recruitment. ß

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Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome

Cited by 171 publications

References 0 publications

Adhesion molecules (E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)) in sera from patients withStaphylococcus aureusbacteraemia with or without endocarditis

Adhesion molecules (E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)) in sera from patients withStaphylococcus aureusbacteraemia with or without endocarditis

Association between thyroid function tests at baseline and the outcome of patients with sepsis or septic shock: a systematic review

Ischemic limb preconditioning downregulates systemic inflammatory activation

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