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These data indicate decreased antioxidant status in the face of enhanced free radical activity, and suggest potential therapeutic strategies involving antioxidant repletion.

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Augmentation of selective serotonin reuptake inhibitors (SSRIs) therapy by the 5-HTThe antidepressant effect of the selective serotonin reuptake inhibitors (SSRIs) is thought to be mediated by enhanced serotonin (5-HT) transmission. However, initial exposure to SSRIs is associated with no change or even a decrease in extracellular 5-HT levels in the terminal fields of the forebrain (Chaput et al. 1986;Invernizzi et al. 1992;

Clinical Pharmacology & Therapeutics (1999) 65, 147–147; doi:

Plasma antioxidant potential is initially decreased in patients with sepsis who develop organ dysfunction, and it increases over time. While we have no clear evidence to prove that this reduction has a causal relationship, failure to achieve a normal plasma antioxidant potential is strongly associated with an unfavorable outcome.

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