Increased Cardiovascular Risk Using Atherogenic Index Measurement Among Healthcare Workers

Juárez-Pérez, Cuauhtémoc Arturo; Aguilar-Madrid, Guadalupe; Haro-García, Luis; Gopar‐Nieto, Rodrigo; Cabello-López, Alejandro; Jiménez-Ramírez, Carmina; Aguado, A Garcia; Martínez-Méndez, Luz María; Chávez-Negrete, Adolfo

doi:10.1016/j.arcmed.2015.03.002

Cited by 17 publications

(16 citation statements)

References 18 publications

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“…In the present study, though all the lipid profile and lipid risk factors were found to be significant (Table 3) we have included only AI in the regression model, as AI has been reported to be the better indicator of CV dysfunction [36]. Among the lipid risk factors, AI has been reported to be associated with SVI [9].…”

Section: Discussionmentioning

confidence: 80%

Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity

Jagadeeswaran

Pal

et al. 2015

Metabolism

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Section: Discussionmentioning

confidence: 80%

Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity

Jagadeeswaran

Pal

et al. 2015

Metabolism

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“…The correlation was negative with HDL and positive with other parameters (BMI, fasting sugar, HbA1c, cholesterol, TG and LDL with age, BMI, fasting sugar, HbA1c and lipid parameters. 11,[26][27][28] Previous studies have also reported significant positive correlation between AIP and uric acid. 29,30…”

Section: Discussionmentioning

confidence: 81%

A study on the lipid ratios and inflammatory markers in pre-diabetic and diabetic patients

Shrestha¹,

Sharma²,

Kumar³

et al. 2019

Int J Res Med Sci

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Background: One of the leading causes of diabetic mortality is cardiovascular disease. Diabetes progression is preceded by pre-diabetic phase which is also at higher cardiovascular risk. Both hyperglycemia and atherosclerotic processes are inflammatory phenomenon. Keeping this in view, it was aimed to evaluate atherogenic indices and correlate them with inflammatory mediators.Methods: This study included 80 controls, 80 pre-diabetic and 80 diabetic patients. Anthropometric parameters (BMI, WHR) and blood parameters like fasting glucose, HbA1c, lipid profile (cholesterol, HDL, LDL TG, VLDL), adiponectin, IL-6, CRP, fibrinogen and uric acid were analysed.Results: Significantly high atherogenic indices were observed in pre-diabetic and diabetic subjects compared to healthy controls. The indices were also significantly correlated with BMI, fasting sugar, HbA1c, cholesterol, HDL, TG and LDL. The correlation with HDL was negative and with other parameters, the correlation was positive. In pre-diabetic patients, adiponectin showed significant negative correlation while fibrinogen and CRP showed significant positive correlation with cardiac risk indices. IL-6 was positively correlated only with AIP while correlation of uric acid with these indices was insignificant. In case of diabetic patients, the cardiac risk indices were significantly correlated with adiponectin, IL-6, CRP, fibrinogen and uric acid. The correlation with adiponectin was negative.Conclusions: The altered atherogenic indices and their significant association with inflammatory markers signify the direct association of inflammation with CVD risks. Thus, there is requirement of novel approaches that can retard inflammatory responses and arrest unwanted cardiac health outcomes.

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“…A previous study suggested that the major factors influencing AIP were gender, obesity, and older age [42]. Accordingly, in this study, a subgroup analysis was performed to determine whether these factors affected the level of AIP.…”

Section: Discussionmentioning

confidence: 96%

Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis

et al. 2020

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Background: To investigate whether atherogenic index of plasma (AIP) at diagnosis is associated with the occurrence of cerebrovascular accident (CVA) or coronary artery disease (CAD) in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods: The medical records of 167 AAV patients on initial diagnosis was reviewed, and 300 healthy controls were included. AIP was calculated using the following equation: AIP = Log (triglyceride [mg/dL] / high-density lipoprotein cholesterol [mg/dL]). AAV patients were divided into two groups according to the AIP cutoff of 0.11. The event of stroke, transient ischemic attack, and cerebral hemorrhage was recorded as CVA, and CAD events consisted of either myocardial infarction and angina pectoris. CVA-and CAD-free survival rate between those with AIP ≥ 0.11 and < 0.11 were compared by the Kaplan-Meier analysis, and Cox hazard analysis was conducted to identify predictors of CVA. Results: The median age of AAV patients were 59.0 years, and 54 (32.3%) patients were male. One-hundred and fifteen (68.9%) patients had AIP < 0.11 and 52 (31.1%) had AIP ≥ 0.11. The mean Birmingham vasculitis activity score in AAV patients with AIP < 0.11 was lower than that seen in patients with AIP ≥ 0.11 (12.0 vs. 14.0, P = 0.041). AAV patients had a significantly higher AIP compared to controls (mean − 0.01 vs.-0.10, P < 0.001). During follow-up, the occurrence of CVA and CAD was observed in 16 (9.6%) and 14 (8.4%) patients, respectively. In Kaplan-Meier analysis, AAV patients with AIP ≥ 0.11 had significantly lower CVA-free survival rates than in those with AIP < 0.11 (P = 0.027), whereas there was no difference in CAD according to AIP (P = 0.390). Multivariable Cox analysis indicated that AIP ≥ 0.11 at diagnosis was the sole predictor of CVA (Hazard ratio 3.392, 95% confidence interval 1.076, 10.696, P = 0.037).

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Increased Cardiovascular Risk Using Atherogenic Index Measurement Among Healthcare Workers

Cited by 17 publications

References 18 publications

Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity

Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity

A study on the lipid ratios and inflammatory markers in pre-diabetic and diabetic patients

Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis

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