Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity

Jagadeeswaran, Indumathy; Pal, Gopal Krushna; Pal, Pravati; Ananthanarayanan, Palakkad Hariharan; Sc, Parija; Balachander, Jayaraman; Dutta, Tarun Kumar

doi:10.1016/j.metabol.2015.09.009

Cited by 35 publications

(35 citation statements)

References 51 publications

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“…Previous work has consistently shown cardiovagal baroreflex sensitivity to be lower in obese adults when compared to lean, healthy controls [7, 12] and our data support this concept (Figure 1a). In contrast, sympathetic baroreflex sensitivity was higher in obese adults when compared to lean controls (Figure 1c–d).…”

Section: Discussionsupporting

confidence: 89%

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Acute cyclooxygenase inhibition and baroreflex sensitivity in lean and obese adults

et al. 2016

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Purpose Obese adults exhibit increased levels of inflammation which may negatively affect blood pressure regulation. Based on existing literature, we hypothesized: 1) baroreflex sensitivity would be lower in obese adults when compared to lean adults, 2) acute ibuprofen (IBU, a cyclooxygenase inhibitor and nonsteroidal anti-inflammatory agent) administration would increase baroreflex sensitivity in obese adults, with no effect in lean adults. Methods Seven lean (4M, 3F) and six obese (5M, 1F) adults completed two visits randomized to control (CON) or IBU (800 mg oral). On each visit, blood pressure (intra-arterial catheter), heart rate (ECG), and muscle sympathetic nerve activity (MSNA, microneurography) were measured continuously. Sympathetic and cardiac baroreflex sensitivity were assessed using the modified Oxford technique. Results Measures of systemic inflammation [C-Reactive protein (CRP) and Interleukin-6 (IL-6)] were higher in obese adults when compared to lean adults, and tended to decrease with IBU (IL-6: p<0.05; CRP: p=0.14). Cardiac baroreflex sensitivity was lower in obese adults (14±2 vs 24±2 ms/mmHg, p=0.02), whereas sympathetic baroreflex sensitivity was higher in obese adults (−3.6±0.5 vs −2.1±0.5 bursts/100 beats/mmHg, p=0.03) when compared to lean. There was no effect of IBU on cardiac or sympathetic baroreflex sensitivity in either group (p-value range 0.20 – 0.71). Conclusion Despite obese individuals exhibiting higher levels of systemic inflammation and lower cardiac baroreflex sensitivity when compared to lean adults, an acute dose of IBU has no effect on cardiac or sympathetic baroreflex sensitivity.

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Section: Discussionsupporting

confidence: 89%

“…In addition, the observed insulin levels were higher than other published studies in obese individuals (e.g. ~35 uU/mL vs ~15 uU/mL) [12, 14]. Recently, insulin (in the form of a hyperinsulinemic, euglycemic clamp) has been shown to increase sympathetic baroreflex sensitivity while having little effect on cardiac baroreflex sensitivity [27].…”

Section: Discussionmentioning

confidence: 90%

Acute cyclooxygenase inhibition and baroreflex sensitivity in lean and obese adults

et al. 2016

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“…Our application is to enable ambulation in people with difficulties performing aerobic exercise using their largest muscle mass, viz. those with diabesity [35], a condition associated with sympathovagal imbalance [36]. The alternative, standing in water, supports body weight, but does not enable walking, limiting the type of exercise for people without access to pools.…”

Section: Introductionmentioning

confidence: 99%

Cardio- and neurometabolic effects of lower-body pressure-supported exercise in obese non-diabetic women: Resetting autonomic imbalance?

Godwin

Uglialoro

Ali

et al. 2017

Preprint

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“…Impaired balance between oxidative stress (i.e., reactive oxygen species (ROS)) and antioxidants is considered as one of the primary causes in the pathogenesis of chronic diseases such as diabetes and CVD and their complications [7–12]. Low levels of ROS produced during the metabolic processes promote cell growth and participate in stress adaptation, injury responses, and various modifications in the cellular phenotype [7].…”

Section: Introductionmentioning

confidence: 99%

Phosphorylation of Histone H2A.X in Peripheral Blood Mononuclear Cells May Be a Useful Marker for Monitoring Cardiometabolic Risk in Nondiabetic Individuals

et al. 2017

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Phosphorylation of H2A.X (serine 139) in the histone H2A family located in the downstream of the DNA damage kinase signaling cascade is an important indicator of DNA damage. Recently, phosphorylation of H2A.X was proposed as a sensitive biomarker of aging. This study investigated if phosphorylation of H2A.X in peripheral blood mononuclear cells (PBMCs) is associated with cardiometabolic risk in nondiabetic individuals. Basic parameters and oxidative stress/inflammatory markers were measured in nondiabetic healthy Koreans (n = 119). Phosphorylation of H2A.X was measured randomly among the study subjects using a flow cytometer. According to the number of metabolic syndrome risk factor (MetS-RF), the study subjects were subdivided into “super healthy” (MetS − RF = 0, n = 71) and “MetS-risk” (MetS − RF ≥ 1, n = 48) groups. Phosphorylation of H2A.X in PBMCs (percentages and mean fluorescence intensity) was significantly higher in the MetS-risk group than in the super healthy group after adjusting for age, sex, cigarette smoking, and alcohol consumption. Phosphorylated H2A.X was positively correlated with the number of MetS-RF as well as waist circumference, blood pressures, triglyceride, HbA1C, oxidized LDL, high sensitivity C-reactive protein, tumor necrosis factor-alpha, and alanine aminotransferase after the adjustment. The present study suggested that phosphorylated H2A.X in circulating PBMCs measured by flow cytometer may be a useful marker for monitoring cardiometabolic risk in nondiabetic individuals.

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Decreased baroreflex sensitivity is linked to sympathovagal imbalance, body fat mass and altered cardiometabolic profile in pre-obesity and obesity

Cited by 35 publications

References 51 publications

Acute cyclooxygenase inhibition and baroreflex sensitivity in lean and obese adults

Acute cyclooxygenase inhibition and baroreflex sensitivity in lean and obese adults

Cardio- and neurometabolic effects of lower-body pressure-supported exercise in obese non-diabetic women: Resetting autonomic imbalance?

Phosphorylation of Histone H2A.X in Peripheral Blood Mononuclear Cells May Be a Useful Marker for Monitoring Cardiometabolic Risk in Nondiabetic Individuals

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