Increased Blood Serotonin and Platelets in Early Infantile Autism

Ritvo, Edward; Yuwiler, Arthur; Geller, Edward; Ornitz, Edward M.; Saeger, K.; Plotkin, Selma

doi:10.1001/archpsyc.1970.01750060086009

Cited by 236 publications

(62 citation statements)

References 18 publications

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“…Previous studies have reported inconsistent results with increased 39,40 and normal platelet counts 41,42 in autistic children. The role of alterations in platelet counts and functions in ASD are not clear.…”

Section: Discussionmentioning

confidence: 87%

Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?

Kutlu¹,

Binici²

2018

Anadolu Psikiyatri Derg

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Section: Discussionmentioning

confidence: 87%

Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?

Kutlu¹,

Binici²

2018

Anadolu Psikiyatri Derg

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“…There were no discernible clinical differences in those autistic subjects with hyperserotonemia and those without. This finding of hyperserotonemia in approximately one-third of children with autism has been consistently replicated (32)(33)(34). Leboyer et al (35) found age-related declines in whole-blood 5-HT in normal controls but not autistic subjects, which is thought to be suggestive of abnormal maturational processes of the 5-HT system in autism (33,35).…”

Section: Serotonin Neurotransmissionmentioning

confidence: 88%

Antipsychotics in the treatment of autism

Posey¹,

Stigler²,

Erickson³

et al. 2008

J. Clin. Invest.

170

104

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Atypical antipsychotics have become indispensable in the treatment of a variety of symptoms in autism. They are frequently used to treat irritability and associated behaviors including aggression and self injury. They may also be efficacious for hyperactivity and stereotyped behavior. This review presents the rationale for the use of this drug class in autism and reviews the most important studies published on this topic to date. Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed.

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“…One of the earliest and most consistent findings in autism research has been the presence of plasma and platelet hyperserotonemia in a significant portion of children and adolescents with autism (Abramson et al 1989;Anderson et al 1987;Leboyer et al 1999;Levy and Bicho 1997;Piven et al 1991;Ritvo et al 1970;Rolf et al 1993;Takahashi et al 1977). Subsequently, the serotonin transporter gene, SERT or SLC6A4 located on chromosome 17q11.1-12 has been widely examined.…”

Section: Serotonergic Systemmentioning

confidence: 99%

Early Pharmacological Treatment of Autism: A Rationale for Developmental Treatment

Bethea

Sikich

2007

Biological Psychiatry

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Autism is a dynamic neurodevelopmental syndrome in which disabilities emerge during the first three postnatal years and continue to evolve with ongoing development. We briefly review research in autism describing subtle changes in molecules important in brain development and neurotransmission, in morphology of specific neurons, brain connections and in brain size. We then provide a general schema of how these processes may interact with particular emphasis on neurotransmission. In this context, we present a rationale for utilizing pharmacologic treatments aimed at modifying key neurodevelopmental processes in young children with autism. Early treatment with selective serotonin reuptake inhibitors (SSRIs) is presented as a model for pharmacologic interventions because there is evidence in autistic children for reduced brain serotonin synthesis during periods of peak synaptogenesis; serotonin is known to enhance synapse refinement; and exploratory studies with these agents in autistic children exist. Additional hypothetical developmental interventions and relevant published clinical data are described. Finally, we discuss the importance of exploring early pharmacologic interventions within multiple experimental settings in order to develop effective treatments as quickly as possible while minimizing risks.

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Increased Blood Serotonin and Platelets in Early Infantile Autism

Cited by 236 publications

References 18 publications

Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?

Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?

Antipsychotics in the treatment of autism

Early Pharmacological Treatment of Autism: A Rationale for Developmental Treatment

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