2008
DOI: 10.1172/jci32483
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Antipsychotics in the treatment of autism

Abstract: Atypical antipsychotics have become indispensable in the treatment of a variety of symptoms in autism. They are frequently used to treat irritability and associated behaviors including aggression and self injury. They may also be efficacious for hyperactivity and stereotyped behavior. This review presents the rationale for the use of this drug class in autism and reviews the most important studies published on this topic to date. Significant adverse effects, including weight gain and the possibility of tardive… Show more

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Cited by 164 publications
(108 citation statements)
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“…[1][2][3] Such treatments appeal to patients both for ''push'' factors (dissatisfaction with traditional approaches, such as the side-effect burden of medications 4 ) as well as ''pull factors'' (an increased sense of agency that patients feel with nontraditional approaches). 5 As recently reviewed, 6,7 there is limited evidence to evaluate such treatments for children with ASD, but insufficient evidence exists to rule out their potential benefit in most cases.…”
mentioning
confidence: 99%
“…[1][2][3] Such treatments appeal to patients both for ''push'' factors (dissatisfaction with traditional approaches, such as the side-effect burden of medications 4 ) as well as ''pull factors'' (an increased sense of agency that patients feel with nontraditional approaches). 5 As recently reviewed, 6,7 there is limited evidence to evaluate such treatments for children with ASD, but insufficient evidence exists to rule out their potential benefit in most cases.…”
mentioning
confidence: 99%
“…When psychosocial and educational interventions are inadequate, pharmacotherapy is indicated [2]. Both atypical antipsychotics, risperidone (Risperdal®) and aripiprazole (Abilify®) are currently FDA-approved to address these behavioural facets [3]. Nonetheless, these agents, along with other antipsychotics, are plagued with a myriad of adverse drug reactions, notably, the neurologic and cardio-metabolic syndromes [4].…”
Section: To the Editormentioning
confidence: 99%
“…Some investigators expand the nature of autism to that of a multisystem metabolic disease, not just a brain disorder (Jepson, 2007a). The term autistic spectrum disorder (ASD) or pervasive developmental disorders (PDDs) represents a group of disorders which includes five diagnostic subtypes including autism, PDD not otherwise specified (PDD-NOS), Rett's disorder, child disintegrative disorder, and Asperger's disorder (Posey et al, 2008). The gender ratio is 3-4 boys:1 girl (Bryson and Smith, 1998).…”
Section: Introductionmentioning
confidence: 99%
“…These criteria are not described in detail, leaving latitude for clinical judgment (Barbaresi et al, 2006). To date, no biological markers have been found to reliably diagnose autism in an individual patient (Posey et al, 2008;Ecker et al, 2010). However, many biomarkers (hormones, peptides, etc.)…”
Section: Introductionmentioning
confidence: 99%