Increased Basal Blood Histamine Levels in Patients with Self-Reported Hypersensitivity to Non-Steroidal Anti-Inflammatory Drugs

Abstract

<b><i>Background:</i></b> Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most prevalent causes of drug hypersensitivity reactions (DHRs), yet the underlying processes are far from clear. Despite the established role of histamine in allergic reactions, its precise implication in DHRs is elusive. <b><i>Objectives:</i></b> This study aimed to explore the connection of basal blood histamine levels to the reported NSAID hypersensitivity. <b><i>Methods:</i></b> Sixteen patients reporting hypersensitivity reactions to a single or multiple NSAIDs and/or paracetamol and 18 healthy volunteers serving as the normal control group enrolled in the study. The medical history was recorded and histamine was quantified spectrophotofluorometrically in whole peripheral blood and plasma. <b><i>Results:</i></b> Compared to the normal group, plasma but not whole blood histamine levels were significantly higher in patients (<i>p</i> < 0.001), mainly in the subgroup reporting hypersensitivity to a single agent (<i>p</i> < 0.001). Plasma histamine levels were significantly correlated with the culprit drug selectivity for cyclooxygenase (COX) isozymes (<i>p</i> < 0.001), with higher levels being obtained in patients reporting reactions to COX-1 than to COX-2 selective inhibitors (<i>p</i> < 0.05). <b><i>Conclusions:</i></b> The findings provide first evidence connecting basal blood histamine levels to the reported NSAID-triggered DHRs. Prospective studies are expected to decipher the contribution of histamine-associated parameters to the mechanisms underlying DHRs.

Histamine and Serotonin Levels in Bone Marrow Stem Cells Niche as Potential Biomarkers of Systemic Mastocytosis and Myeloproliferative Disorders

“…When conducting our targeted profiling studies of bone marrow samples for the presence of low-molecular weight compounds that could be used as potential biomarkers, we noticed significant differences in histamine levels between individual samples. Although histamine levels were measured in other materials such as plasma, blood, urine, gastric juice or cerebrospinal fluid [ 2 – 6 ], for the first time we show here the targeted metabolomic determination of histamine in bone marrow hematopoietic stem cells niche.…”

Rice field purification regulates carp intestinal flora to improve muscle mass

“…Taurine has anti-oxidative and anti-in ammatory properties [27], and long-term dietary taurine supplementation can effectively prevent hypercholesterolemia [28]. Histamine is a biogenic amine that can affect the quality of aquatic products [29], and high concentrations of histamine can cause allergic reactions and poisoning symptoms [30,31].…”