Increase of the total amount of conjugated and unconjugated bilirubin in the normothermic perfused isolated dog kidney system

Schepper, J. De; Stock, Jeffrey

doi:10.1007/bf00586042

Pflugers Arch.

1972

DOI: 10.1007/bf00586042

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Increase of the total amount of conjugated and unconjugated bilirubin in the normothermic perfused isolated dog kidney system

J. De Schepper

Jeffrey Stock

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1973

1985

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Cited by 3 publications

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“…Lin et al (1974) under quite abnormal conditions. These involved the use of the isolated kidney or of the whole animal after hepatectomy (Schoenfield et al, 1961;Royer et al, 1965Royer et al, , 1974De Schepper & Van der Stock, 1972;Franco et al, 1972) or of transplantation of normal rat kidneys into the Gunn rat (Foliot et al, 1975). Under these conditions, urinary secretion of conjugated bilirubin-IXca has been demonstrated in the dog (Barac, 1969;Heirwegh & Barac, 1970; De Schepper & Van der Stock, 1972), but not in the rat.…”

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confidence: 99%

Comparison in different species of biliary bilirubin-IX α conjugates with the activities of hepatic and renal bilirubin-IX α-uridine diphosphate glycosyltransferases

Fevery¹,

Vijver²,

Michiels³

et al. 1977

Biochemical Journal

125

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The bilrubin-IXalpha conjugates in bile and the activities of bilirubin-IX alpha--UDP-glycosyltransferases in liver and kidney were determined for ten species of mammals and for the chicken. 1. In the mammalian species, bilirubin-IX alpha glucuronide was the predominant bile pigment. Excretion of neutral glycosides was unimportant, except in the cat, the mouse, the rabbit and the dog, where glucose and xylose represented 12--41% of total conjugating groups bound to bilirubin-IX alpha. In chicken bile, glucoside and glucuronide conjugates were of equal importance. They probably represent only a small fraction of the total bile pigment. 2. The transferase activities in liver showed pronounced species variation. This was also apparent with regard to activation by digitonin, pH optimum and relative activities of transferases acting on either UDP-glucuronic acid or neutral UDP-sugars. 3. Man, the dog, the cat and the rat excrete bilirubin-IX alpha largely as diconjugated derivatives. In general, diconjugated bilirubin-IX alpha could also be synthesized in vitro with liver homogenate, bilirubin-IX alpha and UDP-sugar. In contrast, for the other species examined, bilirubin pigments consisted predominantly of monoconjugated bilirubin-IX alpha. Synthesis in vitro with UDP-glucuronic acid, UDP-glucose or UDP-xylose as the sugar donor led exclusively to the formation of monoconjugated bilirubin-IX alpha. 4. The transferase activities in the kidney were restricted to the cortex and were important only for the rat and the dog. No activity at all could be detected for several species, including man. 5. Comparison of the transferase activities in liver with reported values of the maximal rate of excretion in bile suggests a close linkage between conjugation and biliary secretion of bilirubin-IX alpha.

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mentioning

confidence: 99%

Comparison in different species of biliary bilirubin-IX α conjugates with the activities of hepatic and renal bilirubin-IX α-uridine diphosphate glycosyltransferases

Fevery¹,

Vijver²,

Michiels³

et al. 1977

Biochemical Journal

125

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Degradation of haemoglobin-14C and urinary excretion of bilirubin-14C by the normothermic perfused isolated dog kidney

Stock

Schepper

1973

Experientia

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Cholestasis

Meyer

Chiapella²

1985

Veterinary Clinics of North America: Small Animal Practice

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Increase of the total amount of conjugated and unconjugated bilirubin in the normothermic perfused isolated dog kidney system

Cited by 3 publications

References 10 publications

Comparison in different species of biliary bilirubin-IX α conjugates with the activities of hepatic and renal bilirubin-IX α-uridine diphosphate glycosyltransferases

Comparison in different species of biliary bilirubin-IX α conjugates with the activities of hepatic and renal bilirubin-IX α-uridine diphosphate glycosyltransferases

Degradation of haemoglobin-14C and urinary excretion of bilirubin-14C by the normothermic perfused isolated dog kidney

Cholestasis

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