Cholestasis

Meyer, Dennis J.; Chiapella, A.M.

doi:10.1016/s0195-5616(85)50012-1

Cited by 9 publications

(2 citation statements)

References 17 publications

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“…The sensitivity of ALT for detection of disease in this study was fairly high, in agreement with some reports and in disagreement with others (Sutherland 1989, Center and others 1991, Jensen 1991 Significantly elevated serum ALP levels were found in dogs with chronic cholangiohepatitis when compared to dogs with other types of chronic liver disease. This is consistent with previous reports, where high levels of ALP were reported in dogs with cholestatic liver disease (Meyer and Chiapella 1985, Center and others 1991. The ALP elevation in cirrhosis is likely to be due to cholestasis secondary to intrahepatic biliary obstruction.…”

Section: Discussionsupporting

confidence: 94%

Diagnosis and prognosis of chronic hepatitis and cirrhosis in dogs

Sevelius

1995

J of Small Animal Practice

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The purpose of this investigation was to evaluate the significance of enzymatic and biochemical analyses in the classification of chronic inflammatory liver disease and to evaluate the prognosis of these diseases. Chronic hepatitis and cirrhosis were diagnosed by histopathological examination in 79 dogs. Decreased appetite and lethargy were the most common owner complaints (46/79). Vomiting and, or, diarrhoea were reported in 27/79 dogs. Ascites was the most common clinical sign (43/79), whereas icterus was a more unusual finding demonstrated in 16/79 dogs. Liver cirrhosis was diagnosed most frequently, in 33/79 dogs, followed by chronic progressive hepatitis (22/79), chronic cholangiohepatitis (13/79), and chronic non-specific hepatitis (11/79). Hypoalbuminaemia was the most consistent biochemical aberration in liver cirrhosis (25/26) and in chronic progressive hepatitis (13/18). These diseases also showed normal to mildly increased concentrations of serum alanine aminotransferase (ALT) and serum gamma-glutamyl transferase (GGT) and a moderate to marked increase of serum alkaline phosphatase (ALP) and fasting serum bile acid (SBA) concentrations. As expected, icterus and markedly elevated ALT, ALP, GGT and SBA levels were demonstrated in chronic cholangiohepatitis. In this disease hypoalbuminaemia was shown in 6/12 dogs, whereas in dogs with chronic non-specific hepatitis, mean SBA and albumin concentrations were normal. In liver cirrhosis the prognosis was poor, with 94 per cent of the dogs dead within one week of established diagnosis. For dogs with the other types of chronic hepatitis the prognosis was more favourable with the mean survival time ranging from 21.1 to 36.4 months.

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Section: Discussionsupporting

confidence: 94%

Diagnosis and prognosis of chronic hepatitis and cirrhosis in dogs

Sevelius

1995

J of Small Animal Practice

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“…Clinical signs, blood chemistry data, and hematologic results were in accordance with previous reports on extrahepatic biliary obstruction in cats and were similar among the three groups 6,8,9,37–39 . These findings led to the suspicion of hepatobiliary disease but did not help to confirm extrahepatic biliary obstruction or the cause of obstruction.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Features of Extrahepatic Biliary Obstruction in 30 Cats

Gaillot

Penninck

Webster

et al. 2007

Vet Radiology Ultrasound

102

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The goals of our study were to review the ultrasonographic features of spontaneous extrahepatic biliary obstruction in cats and to determine whether these features can assist in differentiating tumor, inflammation, and choleliths as the cause of obstruction. Thirty cats with a presurgical ultrasound examination an dconfirmed extrahepatic biliary obstruction were studied. A common bile duct diameter over 5 mm was present in 97% of the cats with extrahepatic biliary obstruction. Gallbladder dilation was seen in < 50% of the cats. Ultrasound identified all obstructive choleliths (calculus or plugs) in the common bile duct. However, neither common bile duct diameter nor appearance or any other ultrasonographic feature allowed differentiation between tumor and inflammation as the cause of obstruction. A short duration of clinical signs (10 days or less) seemed to be associated with obstructive cholelithiasis.

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Platelets and Coagulation

Meyers

1991

Advances in Veterinary Medicine

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Cholestasis

Cited by 9 publications

References 17 publications

Diagnosis and prognosis of chronic hepatitis and cirrhosis in dogs

Diagnosis and prognosis of chronic hepatitis and cirrhosis in dogs

Ultrasonographic Features of Extrahepatic Biliary Obstruction in 30 Cats

Platelets and Coagulation

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