Increase of serum GH concentration following TRH injection in patients with primary hypothyroidism.

Hamada, Noboru; Uoi, Koetsu; Nishizawà, Yoshiki; Okamoto, Teruo; Hasegawa, Kôichi; Morii, Hirotoshi; Wada, Masahisa

doi:10.1507/endocrj1954.23.5

Cited by 30 publications

(12 citation statements)

References 16 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Four of the seven children with prolonged, untreated, acquired, primary hypothyroidism (group B) responded with abnormal ("paradoxical") elevation in serum GH concentrations after TRH. This response has been reported previously in hypothyroid children (3) and adults (4). The cause for the paradoxical GH response in hypothyroidism is not known.…”

Section: Resultssupporting

confidence: 81%

“…Two examples of these alterations are the increased PRL response to TRH (1,2) and the stimulation of GH secretion by TRH in hypothyroid children (3) and adults (4); these responses do not occur in normal subjects (5). It has been shown that many children suffering from congenital hypothyroidism manifest high serum TSH concentrations for prolonged periods despite adequate replacement therapy, clinical euthyrodism, and normal serum levels of thyroid hormones (7)(8)(9)(10).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Thyroid-Stimulating Hormone, Prolactin, and Growth Hormone Response to Thyrotropin-Releasing Hormone in Treated Children with Congenital Hypothyroidism

et al. 1985

View full text Add to dashboard Cite

ABSTRACT. The purpose of the present study was to assess thyroid-stimulating hormone (TSH), prolactin, and growth hormone responses to TRH stimulation in 12 congenitally hypothyroid children adequately treated with Lthyroxine from the first weeks of life. Although clinically euthyroid, six of these children were found to have abnormally high basal serum TSH concentrations despite clinical euthyroidism. Serum triiodothyroxine and L-thyroxine concentrations were normal and did not differ whether the children had elevated or normal basal serum TSH. All six of the children with high basal TSH had an exaggerated TSH response to TRH and 4 of them also had an augmented prolactin response to TRH. The children with normal basal TSH concentrations had normal TSH and prolactin responses to TRH. An abnormal ("paradoxical") elevation of growth hormone concentration in response to TRH was found in four of seven children in a separate group of patients who had prolonged, untreated primary hypothyroidism, but such responses were not found in any of the adequately treated children. These findings suggest the following conclusions: 1) the phenomenon of high serum concentrations of TSH ip conjunction with normal L-thyroxine and triiodothyronine levels (and clinical euthyroidism), is prevalent in congenital hypothyroid patients. 2) These patients have an exaggerated response of their pituitary thyrotroph and lactotroph cells to TRH, presumably caused by selective and relative resistance of these cells to the inhibitory effects of thyroid hormones. 3) Congenital hypothyroidism is not associated with abnormal somatotroph cell responses to TRH. (Pediatr Res 19: 1037-1039,1985 Abbreviations GH, growth hormone PRL, prolactin T3, triiodothyronine T4, L-thyroxine TRH, thyrotropin releasing hormone TSH, thyroid stimulating hormone CH, congenital hypothyroidism tary regulation are well known in hypothyroid patients. Two examples of these alterations are the increased PRL response to TRH (1, 2) and the stimulation of GH secretion by TRH in hypothyroid children (3) and adults (4); these responses do not occur in normal subjects (5). It has been shown that many children suffering from congenital hypothyroidism manifest high serum TSH concentrations for prolonged periods despite adequate replacement therapy, clinical euthyrodism, and normal serum levels of thyroid hormones (7-10). It was suggested that this is due to an elevated threshold for thyrotroph cell TSH suppression by thyroid hormones. The purpose of the present study was to examine both the pituitary-thyroid negative feedback relationship and lactotroph and somatotroph regulation in children with congenital hypothyroidism. MATERIALS AND METHODSTRH tests were performed in 19 children. Group A consisted of 12 congenitally hypothyroid patients aged 1.6 to 9.3 yr attending our clinic for congenital hypothyroidism. All were diagnosed by neonatal thyroid screening during the first weeks of life, and all were treated from the time of diagnosis with T4 and followed by one of us (J.S.). Serum...

show abstract

Section: Resultssupporting

confidence: 81%

mentioning

confidence: 99%

Thyroid-Stimulating Hormone, Prolactin, and Growth Hormone Response to Thyrotropin-Releasing Hormone in Treated Children with Congenital Hypothyroidism

et al. 1985

View full text Add to dashboard Cite

show abstract

“…The serum GH level in response to TRH injection was raised in patients with euthyroid function who had recovered from hypothyroidism following treatment with a preparation of dessicated thyroid (Hamada et al, 1976), but triiodothyronine showed no effect on GH response to TRH in patients with acromegaly (Fagilia et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

“…There also have been many reports suggesting that an elevation of the plasma growth hormone (GH) level could be induced after TRH injection in patients with various diseases including acromegaly or gigantism (Irie and Tsushima, 1972 ;Liuzzi et al, 1976), depression (Maeda et al 1975), renal failure (Gonzalez-Barcerna et al, 1974), primary hypothyroidism (Hamada et al, 1976) and severe liver disease (Pan.erai et al, 1977).…”

mentioning

confidence: 99%

Growth hormone response to thyrotropin-relesing hormone in cancer patients.

et al. 1980

View full text Add to dashboard Cite

Plasma GH responses to TRH were investigated in 50 cancer patients.Out of 50 cancer patients, 33 were found to be responders.At 15, 30 and 60 min after TRH injection, the mean values GH for cancer patients was significantly higher than the corresponding value for normal controls and the base-line level following saline injection in cancer patients (p<0.001).Our results suggests that a possible alteration of hypothalamic-pituitary function regulating GH secretion may occur in patients with cancer.

show abstract

“…Although it is well known that thyrotropin releasing hormone (TRH) stimulates both thyrotropin (TSH) and prolactin (PRL) release from the anterior pituitary in normal subjects (Anderson et al, 1971 ;Bowers et al, 1971 ;Jacobs et al, 1971), it also has been reported that in some pathological conditions such as acromegaly or gigantism (Irie and Tsushima, 1972 ;Schalch et al, 1972;Faglia et al, 1973), primary hypothyroidism (Hamada et al, 1976), anorexia nervosa (Maeda et al, 1976), mental depression (Maeda et al, 1975), chronic liver diseases (Panerai et al, 1977), alcoholic hepatitis with cirrhosis (Zanboni and ZanboniMuciaccia, 1977), liver cancer (Kamijo et al, 1980), chronic renal failure (GonzalezBarcena et al, 1973;Hasegawa et al, 1975), insulin dependent diabetes mellitus (Ceda et al, 1982), and isolated TSH deficiency (Miyai et al, 1976), TRH is able to stimulate growth hormone (GH) release.…”

mentioning

confidence: 99%

Growth hormone response to thyrotropin releasing hormone in a pellagrin.

1984

View full text Add to dashboard Cite

An abnormal hyperresponse of GH to intravenous injection of TRH in a 66-year-old female pellagra patient with typical 3'D's was reported. Diagnosis of pellagra was mainly based on her clinical course and manifestations, although serum levels of nicotinic acid and serotonin were within the normal range. Serum vitamin A and B2 levels were low. However, these findings did not exclude the diagnosis. The abnormal GH response to TRH observed in this patient was decreased at 2 months and thoroughly disappeared at 10 months after admission. GH response to arginine showed an exaggerated and sustained response on admission, decreased at 2 months and showed an almost normal pattern at 10 months after admission. TSH and prolactin response to TRH were normal throughout the clinical course. LH and FSH response to LH-RH were exaggerated, suggesting post-menopausal hypogonadism. Cortisol response to ACTH showed slightly sustained reactions at both times of the provocation.Oral glucose tolerance test revealed a slight impairment in this patient. These results suggest that pellagra is one of the disorders which exhibit an abnormal hyperresponse of GH to intravenous administration of TRH.

show abstract

Increase of serum GH concentration following TRH injection in patients with primary hypothyroidism.

Cited by 30 publications

References 16 publications

Thyroid-Stimulating Hormone, Prolactin, and Growth Hormone Response to Thyrotropin-Releasing Hormone in Treated Children with Congenital Hypothyroidism

Thyroid-Stimulating Hormone, Prolactin, and Growth Hormone Response to Thyrotropin-Releasing Hormone in Treated Children with Congenital Hypothyroidism

Growth hormone response to thyrotropin-relesing hormone in cancer patients.

Growth hormone response to thyrotropin releasing hormone in a pellagrin.

Contact Info

Product

Resources

About