SynopsisThe effect of TRH administration on serum GH was studied in 6 normal subjects, 13 patients with primary hypothyroidism and 6 thyrotoxic subjects. Although no appreciable changes of serum GH were noted in the normal subjects, TRH administration provoked an increase of serum GH in 6 out of 13 patients with primary hypothyroidism.Serum GH levels in response to TRH administration were decreased in patients who were euthyroid following treatment with a preparation of desiccated thyroid.In patients with hyperthyroidism, no significant response of serum GH was observed at 30 or 60 min after TRH administration.Some of the patients with hyperthyroidism showed a slight increase in serum GH at 120 min after TRH injection.These results suggest that hypothalamo-pituitary function regulating GH secretion is altered in patients with primary hypothyroidism.
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