Growth hormone response to thyrotropin-relesing hormone in cancer patients.

In order to investigate whether endogenous GHRH and somatostatin were involved in the mechanism of the paradoxical GH rise after TRH injection, changes in serum GH and plasma GHRH were examined before and after TRH injection in 12 cancer patients and changes in serum TSH and GH were similarly studied in 76 cancer patients including 31 GH-responders and 45 GH-nonresponders to TRH. TRH stimulated GH secretions without altering the circulating GHRH concentration in 4 of the 12 cancer patients.There was neither a significant correlation between the increase from the basal to maximum GH and GHRH after TRH injection in the 12 cancer patients nor a reciprocal relationship between the increase in GH and TSH after TRH injection in the 76 cancer patients.These findings suggested that the paradoxical GH rise after TRH injection in cancer patients was exerted by its direct action at the pituitary level, and not mediated through the hypothalamus.

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“…We have also demonstrated a significant increase in GH after TRH injection in cancer patients (Kamijo et al, 1980(Kamijo et al, , 1983.…”

supporting

confidence: 57%

Effect of Thyrotropin Releasing Hormone Injection on Blood Growth Hormone(GH), TSH and Growth Hormone Releasing Hormone(GHRH) Concentrations in Cancer Patients.

et al. 1988

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“…Although the exact mechanism involved in the various diseases which have shown paradoxical responses of serum GH to TRH still remains unclarified, it has been demonstrated that the phenomenon gradually disappears after recovery from these disease. Previous work from our laboratory has revealed (Kamijo et al, 1980) that the phenomenon in cancer patients also gradually diminishes after curative resection of tumors and there was no significant correlation between GH responses to TRH and weight loss. Maeda et al (1970 and proposed that altered metabolism of brain monoamines may change the response of GH to TRH in depression and anorexia nervosa.…”

Section: Discussionmentioning

confidence: 80%

“…Recently we have demonstrated a significant rise in GH levels after TRH injection in cancer patients (Kamijo et al, 1980). The present study has been directed toward evidence of sex difference in the GH response to TRH in cancer patients.…”

mentioning

confidence: 87%

Sex difference in the paradoxical response of serum GH to thyrotrophin releasing hormone in cancer patients.

Kamijo¹,

Saito²,

Kato³

et al. 1983

Endocrinol Japon

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It was demonstrated that thyrotropin-releasing hormone (TRH) elicited a paradoxical increase in basal GH levels in cancer patients.Out of 94 cancer patients, 50 were found to be GH responders and this phenomenon was more frequently recognized in female than in male cancer patients.In cancer patients under 59 years of age, the GH response to TRH was significantly greater in females than in males, although there was no sex difference in the GH response in patients above 60 years of age. In female cancer patients, the GH response to TRH was significantly greater in patients under 59 years of age than in patients above 60 years of age, while there was no age difference in the GH response in male cancer patients.It was concluded that paradoxical responses of serum GH to TRH were recognized in 53 per cent of cancer patients and were more frequently observed in female than in male cancer patients.

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“…Abnormal GH secretion has incidentally been found in other diseases such as cancer (Kamijo et al 1980), diabetes mellitus (Vigneri et al 1976) anorexia nervosa (Meada et al 1976) and chronic liver disease (Panerai et al 1977). Only one of our patients showed abnormal glucose tolerance and none of the cases had impaired liver function.…”

Section: Discussionmentioning

confidence: 99%

Serum growth hormone in patients with carcinoid tumours; basal levels and response to glucose and thyrotrophin releasing hormone

Öberg

Norheim

Wide

1985

Acta Endocrinologica

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Growth hormone response to thyrotropin-relesing hormone in cancer patients.

Cited by 18 publications

References 4 publications

Effect of Thyrotropin Releasing Hormone Injection on Blood Growth Hormone(GH), TSH and Growth Hormone Releasing Hormone(GHRH) Concentrations in Cancer Patients.

Effect of Thyrotropin Releasing Hormone Injection on Blood Growth Hormone(GH), TSH and Growth Hormone Releasing Hormone(GHRH) Concentrations in Cancer Patients.

Sex difference in the paradoxical response of serum GH to thyrotrophin releasing hormone in cancer patients.

Serum growth hormone in patients with carcinoid tumours; basal levels and response to glucose and thyrotrophin releasing hormone

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