Increase of L‐chain proteins in the sera of patients with systemic lupus erythematosus and the synovial fluids of patients with peripheral rheumatoid arthritis

Epstein, Wallace V.; Tan, Margaret

doi:10.1002/art.1780090508

Cited by 45 publications

(12 citation statements)

References 7 publications

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“…Others [21] have shown enrichment of the 2-type light chain in synovial fluid from patients with RA. This study showed an increase in the light chain content in synovial fluid in twelve of thirteen specimens examined, and L-type was found in greater concentration than ~c-type in some of the fluids examined.…”

Section: Evidence For Restriction Of Synovial Igg Responsementioning

confidence: 97%

“…In one study[21] of the synovial fluid of patients with RA, 12 of 13 synovial fluids showed increased concentrations of light (L)-chain proteins, whereas only one out of nine patients with osteoarthritis or traumatic arthritis showed detectable free L-chains in their synovial fluid. Greater inflammation was accompanied by augmented passage of each protein across the synovial membrane and by a proportionately greater increase in permeability to larger proteins.…”

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confidence: 99%

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Protein synthesis in rheumatoid synovial tissue

1981

Springer Semin Immunopathol

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1. Function of synoviocytes and other cells in the synovium A. Histologic Considerations 1. Electron microscopic studies 2. In vivo and in vitro phagocytosis studies 3. Fluorescent antibody staining B. Culture techniques 1. Problems posed by study of isolated cells 2. Long-term explant cultures 3. Advantages of short-term incubations of synovial fragments 4. Isolation of immunoglobulins C. Non-Immunoglobulin Products of the Synovium 1. Products of normal synovium 2. Alterations induced by rheumatoid arthritis II. The Local Immune response in Rheumatoid Synovitis A. Evidence for Active Immune Stimulation 1. Meditators of cellular immunity in synovial fluid 2. Effect of synovectomy 3. Type and amount of immunoglobulin produced B. Local Commitment of Antibody Response 1. Effect of exogenous immunization 2. Rheumatoid factors. 3. Pepsin agglutinators C. 1. Relative enrichment for IgG-3 subclass 2. Increase in lambda-light chain composition III. Pathogenetic Considerations in Rheumatoid Arthritis A. Comparison of Rheumatoid versus Experimental Immune Synovitis 1. Chronic synovitis as a local immune response. 2. Role of cartilage complexes in substaining chronic synovitis B. Significance of the Restriction in the Immunoglobulin Response in Rheumatoid Arthritis 1. Analogy with other disease states in man 2. Common antigen in RA?

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Section: Evidence For Restriction Of Synovial Igg Responsementioning

confidence: 97%

mentioning

confidence: 99%

Protein synthesis in rheumatoid synovial tissue

1981

Springer Semin Immunopathol

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“…Increased production of SAA or light chains is a prerequisite for, but does not necessarily result, in amyloid deposition (42,43). Therefore, especially among L chains, there may be some whose variable region structure makes them more susceptible to the processing that leads to amyloidosis.…”

Section: Amyloidogenic Proteinsmentioning

confidence: 99%

Amyloidosis

Gorevic¹,

Franklin²

1981

Annu. Rev. Med.

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“…Increased serum levels of monoclonal IgLC are generally associated with malignant clonal B cell proliferation as seen in multiple myeloma and related proliferative disorders, and may be used as a biomarker [7,8]. Moreover, polyclonal IgLC levels are increased markedly in various inflammatory and autoimmune disorders, including multiple sclerosis [9], rheumatoid arthritis [10] and systemic lupus erythematosus [11,12], as well as in cancer [10], AIDS [13] and diabetes mellitus [14,15]. Increased IgLC levels often correlate with disease severity and can be ascribed to increased immune activity [10,16,17].…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin Free Light Chains in Immune Responses

Veeken¹,

Redegeld

2008

CIR

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The functional activity of immunoglobulin free light chains in mast cell-dependent hypersensitivity-like responses implicates a potential role for these molecules in other immune disorders. Mast cell-bound immunoglobulin free light chains recognize antigen and induce mast cell activation and mediator release. Through this mechanism, immunoglobulin free light chains can contribute to the pathogenesis of e.g. contact hypersensitivity and non-atopic asthma. These findings shed new light on the potential role of immunoglobulin free light chains in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. Immunoglobulin free light chain levels are increased in these disorders and correlate with disease activity. Further establishing the contribution of immunoglobulin free light chain-mediated mast cell activation to the pathogenesis of chronic inflammatory diseases may lead to novel therapeutic strategies in their treatment.

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Increase of L‐chain proteins in the sera of patients with systemic lupus erythematosus and the synovial fluids of patients with peripheral rheumatoid arthritis

Cited by 45 publications

References 7 publications

Protein synthesis in rheumatoid synovial tissue

Protein synthesis in rheumatoid synovial tissue

Amyloidosis

Immunoglobulin Free Light Chains in Immune Responses

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