1966
DOI: 10.1002/art.1780090508
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Increase of L‐chain proteins in the sera of patients with systemic lupus erythematosus and the synovial fluids of patients with peripheral rheumatoid arthritis

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Cited by 45 publications
(12 citation statements)
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“…Others [21] have shown enrichment of the 2-type light chain in synovial fluid from patients with RA. This study showed an increase in the light chain content in synovial fluid in twelve of thirteen specimens examined, and L-type was found in greater concentration than ~c-type in some of the fluids examined.…”
Section: Evidence For Restriction Of Synovial Igg Responsementioning
confidence: 97%
See 1 more Smart Citation
“…Others [21] have shown enrichment of the 2-type light chain in synovial fluid from patients with RA. This study showed an increase in the light chain content in synovial fluid in twelve of thirteen specimens examined, and L-type was found in greater concentration than ~c-type in some of the fluids examined.…”
Section: Evidence For Restriction Of Synovial Igg Responsementioning
confidence: 97%
“…In one study[21] of the synovial fluid of patients with RA, 12 of 13 synovial fluids showed increased concentrations of light (L)-chain proteins, whereas only one out of nine patients with osteoarthritis or traumatic arthritis showed detectable free L-chains in their synovial fluid. Greater inflammation was accompanied by augmented passage of each protein across the synovial membrane and by a proportionately greater increase in permeability to larger proteins.…”
mentioning
confidence: 99%
“…Increased production of SAA or light chains is a prerequisite for, but does not necessarily result, in amyloid deposition (42,43). Therefore, especially among L chains, there may be some whose variable region structure makes them more susceptible to the processing that leads to amyloidosis.…”
Section: Amyloidogenic Proteinsmentioning
confidence: 99%
“…Increased serum levels of monoclonal IgLC are generally associated with malignant clonal B cell proliferation as seen in multiple myeloma and related proliferative disorders, and may be used as a biomarker [7,8]. Moreover, polyclonal IgLC levels are increased markedly in various inflammatory and autoimmune disorders, including multiple sclerosis [9], rheumatoid arthritis [10] and systemic lupus erythematosus [11,12], as well as in cancer [10], AIDS [13] and diabetes mellitus [14,15]. Increased IgLC levels often correlate with disease severity and can be ascribed to increased immune activity [10,16,17].…”
Section: Introductionmentioning
confidence: 99%