1981
DOI: 10.1146/annurev.me.32.020181.001401
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Amyloidosis

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Cited by 27 publications
(10 citation statements)
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“…Its serum concentration increases 1,000-fold after acute inflammation, being regulated primarily by the 200 -300-fold increase in SAA gene transcription (32,34,35). In mice, the SAA gene family consists of four genes, SAA1, SAA2, SAA3, and SAA5, and a pseudogene (36,37).…”
mentioning
confidence: 99%
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“…Its serum concentration increases 1,000-fold after acute inflammation, being regulated primarily by the 200 -300-fold increase in SAA gene transcription (32,34,35). In mice, the SAA gene family consists of four genes, SAA1, SAA2, SAA3, and SAA5, and a pseudogene (36,37).…”
mentioning
confidence: 99%
“…Whereas expression of SAA1, SAA2, and SAA3 is dramatically induced after inflammation and each contributes equally to the increased SAA mRNA levels in the liver, SAA5 expression is induced to a much lower level and with different induction kinetics (38,39). In addition to being highly regulated by the inflammatory cytokines, expression of SAA1 and SAA2 are also highly cell type-specific, restricted to the liver hepatocytes (32,34,35). Studies of the rat SAA1 promoter demonstrate that 304 bp of its 5Ј-flanking sequence are sufficient not only for its liver cell-specific expression but also for its cytokine-induced expression in response to inflammatory mediators (40).…”
mentioning
confidence: 99%
“…Due to hyperchemo-taxis of these cells in BD, colchicine has been used with some success [23,24], Moreover, colchicine may inhibit precursor protein synthesis or may inhibit cells responsi ble for proteolysis of serum amyloid A protein (SA A) [25]. This drug is effective prophylactically in FMF [22,26], but has only been employed sporadically for other types of secondary amyloidosis [14,27].…”
Section: Discussionmentioning
confidence: 99%
“…Immunoperoxidase studies with antisera to AA protein, prealbumin, P-component and X and k light chains were performed in selected Congo-red-positive samples as described by Gorovic [ 19].…”
Section: Methodsmentioning
confidence: 99%