Increase in Serum Ca2+/Mg2+ Ratio Promotes Proliferation of Prostate Cancer Cells by Activating TRPM7 Channels

Sun, Yuyang; Selvaraj, Senthil; Varma, Archana; Derry, Susan; Sahmoun, Abe E.; Singh, Brij B.

doi:10.1074/jbc.m112.393918

Cited by 115 publications

(92 citation statements)

References 40 publications

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“…Given the involvement of Mg 2ϩ in cell proliferation, the influx of Mg 2ϩ via TRPM7 has been proposed as the main regulator of tumor growth. However, recent studies using prostate cancer cells suggest that TRPM7-mediated Ca 2ϩ uptake may also play an important role in tumor growth (501). The expression of Mg 2ϩ transporter CNNM3 is increased in human breast cancer tissue (217).…”

Section: Cancermentioning

confidence: 99%

Magnesium in Man: Implications for Health and Disease

Baaij

Hoenderop

Bindels

2015

Physiological Reviews

1,238

1,299

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Section: Cancermentioning

confidence: 99%

Magnesium in Man: Implications for Health and Disease

Baaij

Hoenderop

Bindels

2015

Physiological Reviews

1,238

1,299

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show abstract

“…There is growing interest in understanding the role of TRPM7 overexpression and biochemical pathways implicated with proliferation, migration, and invasion of many types of cancers such as retinoblastoma [17], leukemia [18], prostate [19], and adenocarcinoma [20]. Most recently, high grade gliomas have been investigated for the overexpression of TRPM7 with special emphasis on calcium signaling [21, 22].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, the TRPM7 channel (transient receptor potential melastatin type 7), which is permeable to both Mg 2+ and Ca 2+ , has been implicated with physiological processes such as cellular Mg homeostasis [13], neurotransmitter release [14] and pathological conditions such as atrial fibrillation [15] and cerebral ischemia [16]. Furthermore, TRPM7 has been reported to play a role in the growth, proliferation, and migration of many different types of tumor cells, including retinoblastoma [17], leukemia [18], prostate cancer [19], and ductal adenocarcinoma of the pancreas [20]. The overexpression of TRPM7 in human tissues of pancreatic ductal carcinoma has been correlated with the tumor grade, Ki67 proliferative index, and patient survival [20].…”

Section: Introductionmentioning

confidence: 99%

Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS)

et al. 2015

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Glioblastoma multiforme (GBM) is one of the deadliest forms of human brain tumors. The infiltrative pattern of growth of these tumors includes the spread of individual and/or clusters of tumor cells at some distance from the main tumor mass in parts of the brain protected by an intact blood-brain-barrier. Pathophysiological studies of GBM could be greatly enhanced by analytical techniques capable of in situ single-cell resolution measurements of infiltrating tumor cells. Magnesium homeostasis is an area of active investigation in high grade gliomas. In the present study, we have used the F98 rat glioma as a model of human GBM and an elemental/isotopic imaging technique of secondary ion mass spectrometry (SIMS), a CAMECA IMS-3f ion microscope, for studying Mg distributions with single-cell resolution in freeze-dried brain tissue cryosections. Quantitative observations were made on tumor cells in the main tumor mass, contiguous brain tissue, and infiltrating tumor cells in adjacent normal brain. The brain tissue contained a significantly lower total Mg concentration of 4.70 ± 0.93 mmol/Kg wet weight (mean ± SD) in comparison to 11.64 ± 1.96 mmol/Kg wet weight in tumor cells of the main tumor mass and 10.72 ± 1.76 mmol/Kg wet weight in infiltrating tumor cells (p<0.05). The nucleus of individual tumor cells contained elevated levels of bound Mg. These observations demonstrate enhanced Mg-influx and increased binding of Mg in tumor cells and provide strong support for further investigation of GBMs for altered Mg homeostasis and activation of Mg-transporting channels as possible therapeutic targets.

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“…Later, changes in the expression level of TRPM4 were found to be important for the proliferation of the prostate cancer cells in the androgenindependent phase and cervical cancer-derived HeLa cells [172][173][174]. However the majority of evidence in the TRPM family concentrates on the TRPM7 channel, which is implicated in enhancing proliferative potential of the grade III breast tumour cells [175] as well as participating in gastric and pancreatic cancers [176][177][178], human hypopharyngeal squamous cell and nasopharyngeal carcinomas [179,180], prostate cancer [181] and enhances invasive properties of neuroblastoma [182][183][184].…”

Section: Pro-proliferative Role Of Trpsmentioning

confidence: 97%

Functional and physiopathological implications of TRP channels

Smani

Shapovalov

Skryma

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Transient Receptor Potential (TRP) channel proteins are a diverse family of proteins that are expressed in many organisms, tissues and cell types. TRP channels respond to a variety of stimuli, including light, mechanical or chemical stimuli, temperature, pH or osmolarity. In addition, several TRP family members have been identified as downstream molecules in the G protein-coupled receptor signaling pathway. TRP proteins are involved in a variety of cell functions both in non-excitable and excitable cells due to their diverse permeability to cations and their ability to modulate intracellular Ca2+ signaling. Emerging evidence suggests that TRP channel dysfunction significantly contributes to the physiopathology of a number of diseases, including cardiovascular, neurological, metabolic or neoplastic disorders. This review focuses on the implication of TRP proteins in the pathogenesis of some of the most prevalent disorders in human. We summarize the current findings regarding the role of TRP proteins in the development of cardiovascular disease, diabetes mellitus as well as diabetic complications, and tumorigenesis and present TRP proteins as targets of potential diagnostic and therapeutic strategies.

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Increase in Serum Ca2+/Mg2+ Ratio Promotes Proliferation of Prostate Cancer Cells by Activating TRPM7 Channels

Cited by 115 publications

References 40 publications

Magnesium in Man: Implications for Health and Disease

Magnesium in Man: Implications for Health and Disease

Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS)

Functional and physiopathological implications of TRP channels

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