Incorporation of plant sterols into membranes and its relation to sterol absorption

Edwards, Peter A.; Green, C.

doi:10.1016/0014-5793(72)80026-7

Cited by 32 publications

(13 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1). Accordingly, campesterol exhibits a high potency to stabilize DPPC bilayer (90) and to tightly pack the phospholipid bilayer (91,92), which has been attributed to its smaller freedom of rotation at the C17-hydrocarbon chain. Stigmasterol was previously found to have a much weaker ordering effect than other sterols on diphenylhexatriene anisotropy (93).…”

Section: Free and Conjugated Phytosterols Exhibit Various Abilities Tmentioning

confidence: 99%

Differential Effect of Plant Lipids on Membrane Organization

Grosjean

Mongrand

Beney

et al. 2015

Journal of Biological Chemistry

101

View full text Add to dashboard Cite

Background: The effect of the wide variety of plant lipids on membrane organization is still poorly understood. Results: The local amounts of phytosphingolipids and free and conjugated phytosterols control the relative proportion and spatial distribution of ordered domains. Conclusion: Plant lipids differently modulate, alone or in combination, membrane heterogeneity. Significance: Our results highlight how plant lipid diversity might drive the plasma membrane subcompartmentalization.

show abstract

Section: Free and Conjugated Phytosterols Exhibit Various Abilities Tmentioning

confidence: 99%

Differential Effect of Plant Lipids on Membrane Organization

Grosjean

Mongrand

Beney

et al. 2015

Journal of Biological Chemistry

101

View full text Add to dashboard Cite

show abstract

“…SE is not compatible with phospholipid membranes (I 1), and it predominates in neutral lipid systems such as serum lipoprotein particles. Plant sterols have similar effects to cholesterol on phospholipid bilayers (13), but they are transferred less readily to erythrocyte membranes, indicating that the 24-methyl (campesterol) and 24-ethyl (sitosterol) groups hinder incorporation into the phospholipid bilayer (2).…”

mentioning

confidence: 99%

Effect of Steryl Glycosides on the Phase Transition of Dipalmitoyl Lecithin

Mudd¹,

McManus²

1980

Plant Physiol.

View full text Add to dashboard Cite

The phase transition of dipalmitoyl lecithin, measured by thermal analysis, was eliminated by the plant sterol, sitosterol, and by the derivatives steryl glucoside and acylated steryl glucoside, which were isolated from soybean lipids.When digitonin was added to dipalmitoyl lecithin-sterol mixtures, in amounts equimolar to sterol, the phase transition of the phospholipid was revealed presumably because of the formation of a sterol complex. When digitonin in molar excess of sterol was added, the endothermic peak disappeared again.

show abstract

“…It is noteworthy that maximum incorporation is obtained with testosterone octanoate, since the natural membrane sterol, cholesterol, also has a side chain of eight C atoms. The lowering of incorporation caused by branching or incorporating double bonds into the side chain [table l] is also seen with cholesterol [2,3,7,8]. However, the cholesterol side chain is shortened by being branched at two points while the testosterone octanoate side chain is extended by the ester link itself.…”

Section: Discussionmentioning

confidence: 96%

“…The lowering of incorporation caused by branching or incorporating double bonds into the side chain [table l] is also seen with cholesterol [2,3,7,8]. However, the cholesterol side chain is shortened by being branched at two points while the testosterone octanoate side chain is extended by the ester link itself.…”

Section: Discussionmentioning

confidence: 97%