Differential Effect of Plant Lipids on Membrane Organization

Grosjean, Kévin; Mongrand, Sébastien; Beney, Laurent; Simon-Plas, Françoise; Gerbeau-Pissot, Patricia

doi:10.1074/jbc.m114.598805

Cited by 96 publications

(69 citation statements)

References 128 publications

(112 reference statements)

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“…Nevertheless, a crucial role for ACGal is very likely. In fact, prior studies of acyl steryl glycosides, molecules very similar in structure to ACGal, have shown that acyl steryl glycosides are enriched in DRM from plants (34), and that they stabilize the formation of ordered domains in model membrane vesicles (35). …”

Section: Lipid Rafts In Borreliamentioning

confidence: 99%

Cholesterol lipids and cholesterol-containing lipid rafts in bacteria

Huang

London

2016

Chemistry and Physics of Lipids

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Section: Lipid Rafts In Borreliamentioning

confidence: 99%

Cholesterol lipids and cholesterol-containing lipid rafts in bacteria

Huang

London

2016

Chemistry and Physics of Lipids

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“…First, dietary lipids comprise sterols, which are the main building blocks for biological membranes and lipoproteins (Liu & Huang 2013) and affect their fluidity (Connor et al, 1998;Juan & Bayard, 1995;Carvalho et al, 2012;Brankatschk et al, 2018). Since animals, plants and fungi have very different sterols and because different sterols affect membrane properties differently (Czub & Baginski, 2006;Grosjean, Mongrand, Beney, Simon-Plas, & Gerbeau-Pissot, 2015), diet generally affects membrane composition and fluidity (Brankatschk et al, 2018;Carvalho et al, 2012) but also the fatty acid (FA) profile of sperm and the reproductive tract (Safarinejad, 2011;Comhaire et al, 2000;Knittelfelder et al, 2019). Therefore, the sperm membrane fluidity can reasonably be expected to be affected by dietary lipids in both vertebrates and invertebrates.…”

Section: Introductionmentioning

confidence: 99%

Dietary polyunsaturated fatty acids affect volume and metabolism of Drosophila melanogaster sperm

Guo

Reinhardt

2020

J of Evolutionary Biology

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Dietary fatty acids can accumulate in sperm and affect their function in vertebrates. As Drosophila melanogaster shares several pathways of lipid metabolism and shows similar lipid‐dependent phenotypes but lacks some hormones that in vertebrates regulate lipid metabolism, there is currently no clear prediction as to how dietary fatty acids affect the sperm of D. melanogaster. We manipulated the amount and identity of dietary polyunsaturated fatty acids (PUFA) in the food of D. melanogaster males (a treatment known to affect membrane fluidity) and measured changes in sperm parameters. We found that (a) males reared on food containing PUFA‐rich, plant‐derived lipids showed a slower increase in sperm volume over male age compared to males reared on yeast‐derived lipid food which is richer in saturated fatty acids. (b) The resistance of sperm membrane integrity to osmotic stress was not altered by dietary lipid treatment, but (c) food containing yeast‐derived lipids induced a 46% higher in situ rate of production of reactive oxygen species in sperm cells. These findings show that dietary lipids have similar effects on sperm parameters in Drosophila as in vertebrates, affect some, but not all, sperm parameters and modulate male reproductive ageing. In concert with recent findings of sex‐specific seasonal variation of diet choice in the wild, our results suggest a substantial dietary impact on the dynamics of male reproduction in the wild.

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“…Furthermore, adjusting the sterols composition by altering the diet is an important part of the cold acclimation machinery that, at least in a few organs, functions independently of regulating membranes fluidity by changing the unsaturation of glycerophospholipids. Chol and Cam are having similar membrane ordering capacity, whereas Sit is less ordering and Sti is the least ordering from common fly sterols [8]. Hence the increase of sitosterol with concomitant depletion of (mostly) ergosterol could inrease the membrane fluidity and also contribute to cold acclimation even if unsaturated plant lipids (practically, oil-rich seeds) are not available.…”

Section: Resultsmentioning

confidence: 99%

“…Our recent study showed that switching from yeast to plant diet increased flies survival at low temperatures by preserving the fluidity of their biological membranes [6]. Depending on their chemical structure, sterols are differently contributing to membranes organization and fluidity [8–10]. However, these findings mostly rely on either artificial membrane vesicles or molecular dynamics calculations.…”

Section: Introductionmentioning

confidence: 99%

Sterols as dietary markers forDrosophila melanogaster

Knittelfelder

Prince

Sales

et al. 2019

Preprint

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26During cold acclimation fruit flies switch their feeding from yeast to plant food, however there 27 are no robust markers to monitor it in the wild. Drosophila melanogaster is a sterol auxotroph 28 and relies on dietary sterols to produce lipid membranes, lipoproteins and molting hormones. 29 We employed shotgun lipidomics to quantify eight major food sterols in total extracts of heads, 30 female and male genital tracts of adult flies. We found that their sterol composition is dynamic 31 and reflective of flies diet in an organ-specific manner. Season-dependent changes observed in 32 the organs of wild-living flies suggested that the molar ratio between yeast (ergosterol, 33 zymosterol) and plant (sitosterol, stigmasterol) sterols is a quantifiable, generic and 34 unequivocal marker of their feeding behavior, including cold acclimation. It provides 35 technically simpler and more contrast readout compared to the full lipidome analysis and is 36 suitable for ecological and environmental population-based studies. 37 38 39 3 40 Introduction 41 42 Drosophila melanogaster (Dm) is an established model to study dietary and environmental 43 impact on lipid homeostasis and development [1]. Although in the wild Dm is believed to feed 44 on yeasts grown on rotten fruits and plants, it can also develop on a variety of foods, including 45 an artificially delipidated diet supplemented with sterols [2]. Dm lacks Δ-6 and Δ-5 desaturases 46 [3] and can only produce short-to medium-chain fatty acids comprising not more than one 47 double bond [4]. However, Dm also makes use of dietary lipids with polyunsaturated fatty acid 48 moieties (e.g. unsaturated triacylglycerols from plant oil) and incorporate them into its own 49 lipids [5,6]. Manipulating the composition of laboratory diets helps to produce larvae and adult 50 flies with a varying degree of unsaturation of their glycero-and glycerophospholipids and study 51 their impact on metabolism and physiology. However, changes in lipids unsaturation span 52 many lipid classes in a tissue-dependent manner and therefore a snapshot of the full-lipidome 53 profile could hardly serve as a robust marker of shifting dietary preference. 54 Like other arthropods, Drosophila is a sterol auxotroph: it exclusively relies on dietary 55 sterols to build biological membranes, lipoproteins, and to produce molting hormones [7]. Each 56 common dietary component supplies flies with unique sterols: a commonly used yeast food 57 (YF) is enriched in ergosterol (Erg); plant food (PF) contains phytosterols e.g. sitosterol (Sit), 58 campesterol (Cam) or stigmasterol (Sti), while animal components supply cholesterol (Cho) 59 (Figure 1). We hypothesized that, in comparison to the full lipidome composition, sterol 60 composition could be a more specific dietary marker supporting ecological and nutritional 61 studies also in wild-living animals. 62Our recent study showed that switching from yeast to plant diet increased flies survival 63 at low temperatures by preserving the fluidity of their biological...

show abstract

Differential Effect of Plant Lipids on Membrane Organization

Cited by 96 publications

References 128 publications

Cholesterol lipids and cholesterol-containing lipid rafts in bacteria

Cholesterol lipids and cholesterol-containing lipid rafts in bacteria

Dietary polyunsaturated fatty acids affect volume and metabolism of Drosophila melanogaster sperm

Sterols as dietary markers forDrosophila melanogaster

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