Incorporating Graphene Oxide and Gold Nanoclusters: A Synergistic Catalyst with Surprisingly High Peroxidase‐Like Activity Over a Broad pH Range and its Application for Cancer Cell Detection

Tao, Yu; Lin, Youhui; Huang, Zhenzhen; Ren, Jinsong; Qu, Xiaogang

doi:10.1002/adma.201204419

Cited by 458 publications

(337 citation statements)

References 49 publications

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“…The enriched functional groups can interact in an ionic, covalent or non-covalent manner, so that in principle they provide the highest extraction efficiency of biomolecules per unit area . In recent years, the functionalized GO has been exploited to fabricate biosensors for drug delivery Zhang et al, 2010a), bioimaging in living cells Sun et al, 2008), the detection of cancer cell (Tao et al, 2013), glucose (Song et al, 2010), DNA Gao et al, 2014), enzyme (Zhang et al, 2010b), protein , peptides (Han et al, 2010), and cellulose and lignin .…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Liu

Cai

et al. 2017

Biosensors and Bioelectronics

105

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We explore graphene oxide (GO) nanosheets functionalized dual-peak long period grating (dLPG) based biosensor for ultrasensitive label-free antibody-antigen immunosensing. The GO linking layer provides a remarkable analytical platform for bioaffinity binding interface due to its favorable combination of exceptionally high surface-to-volume ratio and excellent optical and biochemical properties. A new GO deposition technique based on chemical-bonding in conjunction with physical-adsorption was proposed to offer the advantages of a strong bonding between GO and fiber device surface and a homogeneous GO overlay with desirable stability, repeatability and durability. The surface morphology of GO overlay was characterized by Atomic force microscopy, Scanning electron microscope, and Raman spectroscopy. By depositing the GO with a thickness of 49.2 nm, the sensitivity in refractive index (RI) of dLPG was increased to 2538 nm/RIU, 200% that of non-coated dLPG, in low RI region (1.333-1.347) where bioassays and biological events were usually carried out. The IgG was covalently immobilized on GO-dLPG via EDC/NHS heterobifunctional cross-linking chemistry leaving the binding sites free for target analyte recognition. The performance of immunosensing was evaluated by monitoring the kinetic bioaffinity binding between IgG and specific anti-IgG in real-time. The GO-dLPG based biosensor demonstrates an ultrahigh sensitivity with limit of detection of 7 ng/mL, which is 10-fold better than non-coated dLPG biosensor and 100-fold greater than LPG-based immunosensor. Moreover, the reusability of GO-dLPG biosensor has been facilitated by a simple regeneration procedure based on stripping off bound anti-IgG treatment. The proposed ultrasensitive biosensor can be further adapted as biophotonic platform opening up the potential for food safety, environmental monitoring, clinical diagnostics and medical applications.

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Section: Introductionmentioning

confidence: 99%

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Liu

Cai

et al. 2017

Biosensors and Bioelectronics

105

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“…Successful synthesis of materials like small β −C 3 N 4 crystals, amorphous CN films 6,7 and nanofibers made from C 3 N 4 and CN have been reported. 8 Due to the recent successfull isolation of graphene membranes, 9 with its unique electrical and mechanical properties [10][11][12][13] and various applications in nanotechnology, [14][15][16][17] there has been a renewed interest in two dimensional materials. Other two dimensional structures, such as boron nitride 18 and silicene, 19 among others, have been object of recent investigations.…”

Section: Introductionmentioning

confidence: 99%

Mechanical and structural properties of graphene-like carbon nitride sheets

et al. 2016

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Carbon nitride-based nanostructures have attracted special attention (from theory and experiments) due to their remarkable electromechanical properties. In this work we have investigated the mechanical properties of some graphene-like carbon nitride membranes through fully atomistic reactive molecular dynamics simulations. We have analyzed three different structures of these CN families, the so-called graphene-based g-CN, triazine-based g-C 3 N 4 and * To whom correspondence should be addressed †1 1 heptazine-based g-C 3 N 4 . The stretching dynamics of these membranes was studied for deformations along their two main axes and at three different temperatures: 10K, 300K and 600K.We show that g − CN membranes have the lowest ultimate fracture strain value, followed by heptazine-based and triazine-based ones, respectively. This behavior can be explained in terms of their differences in terms of density values, topologies and types of chemical bonds. The dependency of the fracture patterns on the stretching directions is also discussed.

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“…A hybrid material based on gold clusters and graphene oxide was synthesized, which demonstrated a surprising synergistic effect. 20 The resulting activities are much higher than those of isolated materials. Surprisingly, pure carbon materials also have an intrinsic peroxidase-like activity.…”

Section: -7mentioning

confidence: 99%

Iron-core/carbon-shell nanoparticles with intrinsic peroxidase activity: new platform for mimetic glucose detection

et al. 2017

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Artificial enzymatic mimics based on nanoparticles have become a powerful tool for the improvement of analytical performance in the detection of important bioactive compounds. For the first time the intrinsic peroxidase-like activity of Fe-core/carbon shell nanoparticles (Fe@C NPs) was studied. The catalytic process was described by a typical Michaelis-Menten curve for enzyme kinetics, and the results were comparable with those previously published. The high catalytic performance of the Fe@C NPs allows the development of a new simple procedure for glucose determination with a low detection limit of 0.21 mM. To our knowledge, this is the first study showing the ability to generate active oxygen species on the Fe@C surfaces. We suppose that our investigation will open up a new direction in medicinal applications using these promising materials.

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Incorporating Graphene Oxide and Gold Nanoclusters: A Synergistic Catalyst with Surprisingly High Peroxidase‐Like Activity Over a Broad pH Range and its Application for Cancer Cell Detection

Cited by 458 publications

References 49 publications

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Mechanical and structural properties of graphene-like carbon nitride sheets

Iron-core/carbon-shell nanoparticles with intrinsic peroxidase activity: new platform for mimetic glucose detection

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