Inclusion of spironolactone in cyclomaltoheptaose: A guest affected by the hospitality of the host

Cyclodextrin Complexation as a Way of Increasing the Aqueous Solubility and Stability of Carvedilol

“…It has been reported that CDs can protect drugs from photo-oxidation and that the hydroxyl substituents' electron-donating tendency may dampen this protective effect [12,31]. In contrast, it has been shown that the free hydroxyls of CDs can hydrolyze guest molecules in the cavity [32]. The results of our six-month ICH-standard study at the target concentration (5 mg/mL) supported these findings; RAMEB was more protective than γCD, which in turn was more protective than an acetonitrile/H 2 O mixture.…”

Cyclodextrin‐Catalyzed Deacetylation of Spironolactone is pH and Cyclodextrin Dependent

“…The studies were performed with ␤-CD and SP because the side chain of the CD derivatives makes the interpretation of NMR spectra more complicated. In a previous study, Wouessidjewe et al 16 noted that complexation of SP results in chemical shift changes at H-7 and H-9 of SP. These authors proposed a 2 : 1 ␤-CD:SP complex.…”

“…In earlier studies, CDs have been shown to increase aqueous solubility, dissolution rate, and bioavailability of SP. [7][8][9][10][11][12][13][14] However, studies had also shown that the complexation of SP with ␤-CD 15,16 and some commonly used CD-derivatives 17 increases the deacetylation of SP, which brings into question the use of CDs in SP formulations. In the Kaukonen et al study, 17 it was observed that CD derivatives showed a differing ability to catalyze the deacetylation of SP.…”

Polymorphism of Spironolactone

“…2 The preparation of this inclusion complex can be carried out using the coprecipitation method in an organo-aqueous medium (e.g., acetonitrile, acetone).…”