Polymorphism of Spironolactone

Agafonov, V.; Légendre, B.; Rodier, N.; Wouessidjewe, Denis; Cense, J. M.

doi:10.1002/jps.2600800221

Cited by 37 publications

(23 citation statements)

References 12 publications

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“…Also, this indicated that there was no other crystalline phase, such as that detected in recent reports for different polymorphs. [87][88][89][90]…”

Section: Crystengcomm Papermentioning

confidence: 99%

The effect of the supramolecular network of (Z)-3-(4-(diphenylamino)phenyl)-2-(pyridin-2-yl)-acrylonitrile on the fluorescence behavior of a single crystal: experimental and theoretical studies

et al. 2014

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“…Also, this indicated that there was no other crystalline phase, such as that detected in recent reports for different polymorphs. [87][88][89][90]…”

Section: Crystengcomm Papermentioning

confidence: 99%

The effect of the supramolecular network of (Z)-3-(4-(diphenylamino)phenyl)-2-(pyridin-2-yl)-acrylonitrile on the fluorescence behavior of a single crystal: experimental and theoretical studies

et al. 2014

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“…1) is a steroidal diuretic which is described as a light, cream-colored to light tan, crystalline powder with a faint to mild mercaptan-like odor, practically insoluble in water, soluble in alcohol and in ethyl acetate, freely soluble in chloroform and in benzene, and slightly soluble in methyl alcohol and in fixed oils [8]. It is a poorly soluble drug substance, which has been reported to have differences in solubility [9]. Because of its low water solubility and slow dissolution rate, spironolactone shows a variable and incomplete oral absorption [10].…”

Section: Introductionmentioning

confidence: 99%

Physical-chemical characterization and quality control of spironolactone raw material samples

et al. 2008

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It is well established that solid-state properties such as solubility, particle size, and morphology are critical factors in the development of pharmaceutical formulations. Thus, the evaluation of the physical-chemical properties of the substances that will be used must be the primary step for quality control in the pharmacy industry. The aim of this report is to characterize and to establish the quality of four spironolactone raw samples, derived from distinct laboratories, through thermal analysis (DSC and TG), infrared spectroscopy (IV), solubility assay, scanning electron microscopy, and digital image analysis. Capsules of spironolactone were also prepared with these different drug samples and dissolution profiles determined. The IR and the DSC assays confirmed the identity of the samples as spironolactone. Morphological differences relating to shape, size, and particle size distribution were found and can be directly related to the varied dissolution profiles presented by the different formulations.

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“…There was a slight difference between the onset temperatures of the two polymorphs. It was reported that two polymorphs of spironolactone also had similar melting points of 205°C and 210°C, respectively [29] . It was noted that both were high‐melting polymorphs with high enthalpy of fusion.…”

Section: Resultsmentioning

confidence: 95%