Cyclodextrin‐Catalyzed Deacetylation of Spironolactone is pH and Cyclodextrin Dependent

Phase solubility and structure of the inclusion complexes of prednisolone and 6α‐methyl prednisolone with various cyclodextrins

“…Similar results have been obtained with various other steroids,5,13 albeit, improved complex stability relative to native β‐CD has also been observed 13,27,32. Studies on the complex stability of several neutral drug molecules, including steroids, have shown that (SBE) 7M ‐β‐CD forms stronger inclusion complexes compared with HP‐β‐CD 25,27,32. There may be several explanations for the differences observed on the binding of neutral molecules studied by (SBE) 7M ‐β‐CD, HP‐β‐CD, and native β‐CD as discussed by Zia and coworkers 25,27,29.…”

“…When comparing the association constants for native β‐CD and its HP and SBE derivatives, a decrease in complex stability is observed for both prednisolone and 6α‐methyl prednisolone with HP‐β‐CD forming the weakest complex (Table 1). Similar results have been obtained with various other steroids,5,13 albeit, improved complex stability relative to native β‐CD has also been observed 13,27,32. Studies on the complex stability of several neutral drug molecules, including steroids, have shown that (SBE) 7M ‐β‐CD forms stronger inclusion complexes compared with HP‐β‐CD 25,27,32.…”

Utilization of Cyclodextrins by Trichoderma Species

“…On account of their relatively hydrophobic interiors, CDs have the ability to form inclusion complexes with a wide range of substrates in aqueous solution or heterogenic systems [2,3]. This property of CDs has led to their application in areas as varied enzyme mimics [4][5][6], catalysis [7][8][9], environmental protection [10][11][12], and the encapsulation of drugs [13][14][15][16] and pesticides [17,18]. Although CDs are frequently employed in various industrial processes as carriers [19,20] few attention has been paid to the study of their fate In biological systems [21][22][23].…”

Effect of Cyclodextrin Derivation and Amorphous State of Complex on Accelerated Degradation of Ziprasidone

“…Nevertheless, as the free radical cation forms, the electron‐donating group in the vicinity could provide stabilization if the right interaction could be achieved. The mechanism of neighboring group assistance in catalyzing oxidation by stabilizing the free radical intermediate has been well documented 6. Such neighboring group participation has been also shown for hydrolysis10 and dimmerization reactions 11…”

“…There have been reports of CD stabilizing drugs as well as catalyzing degradation of drugs 5–6. However, a systematic study on the effect of side chain on drug stability and the mechanism for catalysis does not exist.…”