Inclusion of an antiplatelet agent inside into β-cyclodextrin for biochemical applications with diverse authentications

Probing the Molecular Assembly of a Metabolizer Drug with β-Cyclodextrin and Its Binding with CT-DNA in Augmenting Antibacterial Activity and Photostability by Physicochemical and Computational Methodologies

“…The intercept is divided by the slope of the straight line of the double reciprocal plot to get the value of the analyzed system’s association constant ( Table 2 ). 27 …”

“…The percentage of cytotoxicity resembles the loss of cellular viability during drug treatment. 24 , 27 The more toxic the drug is, the more it can reduce the reproducibility of a cell. In case of the kidney cancer cell line (ACHN), the cytotoxicity caused by IC is much higher than the toxicity caused by the control drug (dyphylline).…”

“…The surface character, morphology, and particle size of solid sample entities can all be examined using scanning electron microscopy. This advances our knowledge of how ICs between the dyphylline and β-CD molecules form. , The surface morphology of pure dyphylline, β-CD, and the ICs that result is shown in Figure . Individual pure β-CDs may be seen on SEM images due to their cubic type size or polyhedral crystal-like structure, but dyphylline has a structure that is comparable to that of a long rectangular irregular shape type crystal and can be readily seen due to its odd shape.…”

“…In case of the kidney cancer cell line (ACHN), the cytotoxicity caused by IC is much higher than the toxicity caused by the control drug (dyphylline). In the inclusion-complex-treated cells, there is a significant loss of cells observed when compared with the control-drug-treated cells. , This observation indicates that the inclusion complex is more toxic than the control one (Figure ). The IC 50 value signifies the loss of initial cellular density to its 50% concentration.…”

“…The Benesi−Hildebrand approach was used to generate the double reciprocal plot (Figure S3) for the 1: The intercept is divided by the slope of the straight line of the double reciprocal plot to get the value of the analyzed system's association constant (Table 2). 27 We can easily get the thermodynamic parameter from the association constant derived from the previous equation using the following free-energy-related equation:…”