Inclusion body hepatitis (IBH) outbreak associated with fowl adenovirus type 8b in broilers

Zadravec, Marko; Slavec, Brigita; Krapež, Uroš; Kaján, Gyözö L.; Račnik, Jožko; Juntes, Polona; Cizerl, R. J.; Benkő, Mária; Rojs, Olga Zorman

doi:10.2298/avb1301101z

Cited by 24 publications

(19 citation statements)

References 25 publications

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“…An enlarged spleen is rarely reported in association with IBH in the literature Zadravec et al, 2013), and when reported has been more frequently associated with HPS (Cowen, 1992;Asrani et al, 1997). The observation of an enlarged spleen at necropsy in FAdV-8b and FAdV-11 inoculated birds in this study coincided with the histological observation of morphological changes of some cells and depletion of the white pulp, as well as the observation of INIBs in the liver.…”

Section: Discussionsupporting

confidence: 85%

“…FAdV-8b and FAdV-11 have been identified in several countries in association with IBH (Ojkic et al, 2008;Lim et al, 2011;Zadravec et al, 2011;Hess, 2013), as well as with HPS (Nakamura et al, 2000) and gizzard erosion (Okuda et al, 2004). The primary purpose of this investigation was to determine if field strains of FAdV-1, FAdV8b and FAdV-11, all isolated in association with IBH field outbreaks without evidence of immunosuppression, are primary pathogens.…”

Section: Discussionmentioning

confidence: 99%

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Chronological analysis of gross and histological lesions induced by field strains of fowl adenovirus serotypes 1, 8b and 11 in one-day-old chickens

et al. 2015

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Fowl adenoviruses (FAdVs) cause diseases in domestic chickens, including inclusion body hepatitis (IBH), with immunosuppression believed to play a role in their pathogenesis. To gain a better understanding of the pathogenesis and chronology of disease caused by FAdVs, the gross pathology, histopathology and dissemination of virus were examined at several different time points, after inoculation of one-day-old specific pathogen-free chickens with FAdV-1, FAdV-8b or FAdV-11 via the ocular route. FAdV-8b had a slightly greater virulence than FAdV-11, but both were primary pathogens. The presence and severity of hepatic lesions were used to define the three stages of the disease: incubation (1-3 days post-inoculation, PI), degeneration (4-7 days PI) and convalescence (14 days PI). Both viruses were detected in the liver, kidney, bursa, thymus and gizzard of most birds during the degenerative stage, and persisted in the gizzard into convalescence. The FAdV-1 isolate was found to be apathogenic, but virus was detected in the bursa and/or gizzard of several birds between 2 and 7 days PI. This is the first study examining the chronology of gross and microscopic lesions of pathogenic and apathogenic FAdVs in association with viral presence in multiple tissues. It was concluded that both FAdV-8b and FAdV-11 are primary pathogens, and that these strains may play a role in immunosuppression.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Chronological analysis of gross and histological lesions induced by field strains of fowl adenovirus serotypes 1, 8b and 11 in one-day-old chickens

et al. 2015

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“…In recent years, IBH outbreaks caused by different FAdV serotypes have been described in Canada (Philippe et al, 2005;Ojkic et al, 2008a, b;Grgic et al, 2011;Dar et al, 2012), the USA (Wilson et al, 2010), the Republic of Korea (Choi et al, 2012), India (Thakor et al, 2012), South Africa (Joubert et al, 2014), Japan (Nakamura et al, 2011), China (Zhao et al, 2015), Australia (Steer et al, 2011) and in some European countries (Pizzuto et al, 2010;Zadravec et al, 2011Zadravec et al, , 2013Kajan et al, 2013;Schachner et al, 2016). Most of these outbreaks have been associated with genotypes FAdV-D, -E or -C, with serotypes 2, 4, 8b and 11 being the most frequently involved.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological and pathological investigation of fowl aviadenovirus serotypes 8b and 11 isolated from chickens with inclusion body hepatitis in Spain (2011–2013)

et al. 2016

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Inclusion body hepatitis caused by different fowl aviadenovirus (FAdV) serotypes has been described in several countries in recent years. In Spain, from the spring of 2011 to 2013, an increased number of outbreaks in broiler and broiler breeder flocks from different regions occurred. The objectives of the present work were to carry out the molecular characterization of FAdV strains from Spanish inclusion body hepatitis cases and to study the pathogenicity and viral dynamics of these strains in specific pathogen-free (SPF) chickens. A total of 52 inclusion body hepatitis clinical cases, including 45 from broiler farms and seven from broiler breeder farms, were analysed by conventional polymerase chain reaction and sequencing targeting the FAdV hexon gene. From these, 37 strains were classified as FAdV type 8b, while the remaining 15 were classified as FAdV types 11 (n = 10), 2 (n = 4) and 8a (n = 1). In addition, two different FAdVs belonging to the genotypes 8b and 11 were used for experimental infection. Specific pathogen-free five-day-old birds were inoculated intramuscularly with a high (10 tissue culture infective dose (TCID)/ml) or low (10 TCID/ml) dose of the above-mentioned FAdVs. No mortality was observed in any of the experimental groups, and only one bird showed evident clinical signs. However, macroscopic and microscopic hepatic lesions, as well as viral DNA, were detected in birds from all infection groups. Inclusion bodies and viral DNA were also detected in the pancreas and in the small and the large intestine in some birds. Long-lasting shedding and transmission to contact birds were confirmed in all infected groups.

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“…E.g. recent research shows that only specific and not all serotypes of the species Fowl aviadenovirus D and E cause inclusion body hepatitis in chicken (Schachner et al 2018;Zadravec et al 2011). But recent host switches might result in an elevated pathogenicity (Benkő and Harrach 2003;Jánoska et al 2011;Kohl et al 2012;Vidovszky et al 2015).…”

Section: Adenovirusesmentioning

confidence: 99%

Virus–Host Coevolution with a Focus on Animal and Human DNA Viruses

et al. 2019

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Viruses have been infecting their host cells since the dawn of life, and this extremely long-term coevolution gave rise to some surprising consequences for the entire tree of life. It is hypothesised that viruses might have contributed to the formation of the first cellular life form, or that even the eukaryotic cell nucleus originates from an infection by a coated virus. The continuous struggle between viruses and their hosts to maintain at least a constant fitness level led to the development of an unceasing arms race, where weapons are often shuttled between the participants. In this literature review we try to give a short insight into some general consequences or traits of virus-host coevolution, and after this we zoom in to the viral clades of adenoviruses, herpesviruses, nucleo-cytoplasmic large DNA viruses, polyomaviruses and, finally, circoviruses.

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Inclusion body hepatitis (IBH) outbreak associated with fowl adenovirus type 8b in broilers

Cited by 24 publications

References 25 publications

Chronological analysis of gross and histological lesions induced by field strains of fowl adenovirus serotypes 1, 8b and 11 in one-day-old chickens

Chronological analysis of gross and histological lesions induced by field strains of fowl adenovirus serotypes 1, 8b and 11 in one-day-old chickens

Epidemiological and pathological investigation of fowl aviadenovirus serotypes 8b and 11 isolated from chickens with inclusion body hepatitis in Spain (2011–2013)

Virus–Host Coevolution with a Focus on Animal and Human DNA Viruses

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