Inclusion Body Hepatitis Caused by Fowl Adenovirus in Broiler Chickens in Japan, 2009–2010

Nakamura, Kikuyasu; Mase, Masaji; Yamamoto, Yu; Takizawa, Katsutoshi; Kabeya, Masahiko; Wakuda, Takashi; Matsuda, Monique; Chikuba, Takumi; Yamamoto, Yasutake; Ohyama, Takayuki; Takahashi, Kazuhiko; Sato, Naoto; Akiyama, Nobuyuki; Honma, Hirokazu; Imai, Kunitoshi

doi:10.1637/9948-981311-digest.1

Cited by 7 publications

(12 citation statements)

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“…The age of IBH positive chickens ranged from 1 to 7 weeks, but the highest prevalence was observed in the 4 th week of life (Table 2). This is consistent with published data from other authors (Singh et al 1996, Nakamura et al 2011, Dolka et al 2012, Niczyporuk et al 2013). In the samples from broiler chickens that were in their 2 nd and 3 rd week of life IBH seemed to be a primary infection.…”

Section: Resultssupporting

confidence: 94%

“…Inclusion body hepatitis (IBH) is an emerging pathogen that has economic significance for the global chicken industry (Gomis et al 2006, Ojkic et al 2008, Nakamura et al 2011. IBH is an acute, viral infection that affects broiler chickens between 2 and 7 weeks of age.…”

Section: Introductionmentioning

confidence: 99%

“…IBH is an acute, viral infection that affects broiler chickens between 2 and 7 weeks of age. The disease manifests suddenly, has a short clinical course (4-5 days), and is associated with increased mortality rates generally from 1-20% (Gomis et al 2006, Nakamura et al 2011), but occasionally exceeding 30-40% (Erny et al 1991). Infected chickens typically have pale, friable, swollen livers with focal to extensive necrosis, and large basophilic inclusion bodies in hepatocytes (Reece et al 1986).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of inclusion body hepatitis (IBH) in Poland from 2010-2014

Gaweł¹,

Nowak²,

Ciaputa³

et al. 2016

Polish Journal of Veterinary Sciences

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This study investigated the prevalence of inclusion body hepatitis (IBH) infections during the past five years (2010)(2011)(2012)(2013)(2014) in broiler chicken flocks in Poland. The diagnosis of IBH was based on anatomopathological investigations and histopathological analyzes. IBH was the most prevalent disease in broiler flocks in Poland (10.4%) during this time period, and occurred as a primary infection. The fewest cases of IBH occurred in the summer, suggesting that the temperature may have been a possible stressor that increased susceptibility to IBH. However, over the last 5 years the occurrence of clinical IBH cases in Poland has systematically decreased.

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Section: Resultssupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of inclusion body hepatitis (IBH) in Poland from 2010-2014

Gaweł¹,

Nowak²,

Ciaputa³

et al. 2016

Polish Journal of Veterinary Sciences

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“…Later, several reports described IBH as a primary disease without the association of infectious bursal disease virus or chicken anaemia virus (Gomis et al 2006;Nakamura et al 2011). The fact that only one flock in our case exhibited clinical signs of IBH prompted us to examine the possible association of IBH with the presence of two types of intranuclear inclusions: basophilic, filling almost the whole nucleus (Figure 2), and eosinophilic, with a halo zone at the periphery.…”

Section: Discussionmentioning

confidence: 79%

An unusual outbreak of inclusion body hepatitis on a broiler chicken farm: a case report

Révajová¹,

Herich²,

Seman³

et al. 2017

Vet. Med. - Czech

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ABSTRACT:This study investigated an outbreak of inclusion body hepatitis in ROSS 308 hybrid broiler type chickens between 19 and 25 days of fattening. For this purpose, clinical observation, ELISA fowl adenovirus and chicken anaemia virus antibody detection in serum at 21 and 42 days, mortality evaluation, epidemiological analysis, histology and genetic identification were performed. The six flocks of the farm consisted of 90,000 chickens. Only one flock of 15,000 chickens was affected on this farm. At 19 days of age, ill chickens showed clinical signs of depression, anorexia, somnolence, ruffled feathers, anaemic comb and wattles and occasionally nervous signs. Based on ELISA titres, the antibody response to fowl adenovirus increased greatly from 21 to 42 days. The antibody response to vaccination against infectious bursal disease virus and chicken anaemia virus was at the expected level in all broiler flocks. Necropsy showed diffuse petechial and ecchymotic haemorrhages in skeletal muscles, liver, pancreas, kidney, together with hepatomegaly, splenomegaly and catarrhal enteritis. Histologically, fatty liver degeneration, multifocal liver necrosis and intranuclear inclusions in hepatocytes, as well as focal necrosis in pancreas and spleen parenchyma were seen. The DNA of AAV-1 (avian adenovirus group 1) was detected using the PCR method in paraffin-embedded liver samples. The results revealed no association of inclusion body hepatitis with infectious bursal disease virus or chicken anaemia virus infection, and suggested primary disease. However, the involvement of only one chicken flock on the farm remains unexplained.

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“…Conventionally, IBH/HPS outbreaks are diagnosed on the basis of clinical signs, gross pathological lesions, histopathology and/or agar gel precipitation test [1,14,15]. Molecular techniques like polymerase chain reaction followed by restriction enzyme analysis (REA) and sequencing have been used for the rapid detection and differentiation of FAdVs [4,5,9,10,12,16].…”

Section: Introductionmentioning

confidence: 99%

Characterization of fowl adenoviruses associated with hydropericardium syndrome and inclusion body hepatitis in broiler chickens

et al. 2013

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The present study was carried out for detection and molecular characterization of fowl adenoviruses (FAdVs) associated with hydropericardium syndrome or inclusion body hepatitis in commercial broiler chickens. The FAdVs were detected in liver samples from 33 commercial broiler chicken flocks by polymerase chain reaction (PCR) using hexon gene specific primers. The restriction enzyme analysis using StyI, BsiWI, MluI, AspI, BglI and ScaI enzymes of all the 33 FAdV-positive samples revealed FAdV-4 in 10 samples, FAdV-8 in five samples, FAdV-2 and FAdV-12 in two samples each, and FAdV-5 and FAdV-6 in one sample each. Twelve samples revealed the digestion pattern for more than one serotypes with FAdV-8 and FAdV-5, FAdV-8 and FAdV-7, FAdV-8 and FAdV-6, FAdV-8 and FAdV-12 being the predominant combinations indicating mixed infection. The serotypes FAdV-2 and FAdV-5 have not been detected previously in the country. The purified PCR products of FAdVs of four samples (HR 1, HR 2, HR 3 and HR 4) were cloned and sequenced. Phylogenetic analysis revealed that FAdVs of all four samples clustered in separate groups consistent with the REA pattern. In conclusion, this study reveals the presence of FAdV-2, FAdV-4, in broiler chickens affected with hydropericardium syndrome or inclusion body hepatitis in India.

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Inclusion Body Hepatitis Caused by Fowl Adenovirus in Broiler Chickens in Japan, 2009–2010

Cited by 7 publications

References 0 publications

Prevalence of inclusion body hepatitis (IBH) in Poland from 2010-2014

Prevalence of inclusion body hepatitis (IBH) in Poland from 2010-2014

An unusual outbreak of inclusion body hepatitis on a broiler chicken farm: a case report

Characterization of fowl adenoviruses associated with hydropericardium syndrome and inclusion body hepatitis in broiler chickens

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