Incidence of Lung, Eye, and Skin Lesions as Late Complications in 34,000 Iranians With Wartime Exposure to Mustard Agent

Khateri, Shahriar; Ghanei, Mostafa; Keshavarz, Saeed; Soroush, Mohammad Reza; Haines, David

doi:10.1097/01.jom.0000094993.20914.d1

Cited by 290 publications

(230 citation statements)

References 30 publications

Supporting

Mentioning

214

Contrasting

Unclassified

Order By: Relevance

“…Long-term pulmonary complications from sulfur mustard (SM) exposure have included chronic obstructive pulmonary disease (COPD), chronic bronchitis, bronchiolitis obliterans, bronchiectasis, airway hyper-reactivity, and lung fibrosis (Balali-Mood et al, 2005;Emad & Rezaian, 1997;Ghanei et al, 2008a,b;Khateri et al, 2003). The SM-exposed patients suffer from pulmonary disorders due to previous documented exposure to a single high dose of SM gas they faced during the Iran-Iraq conflict in 1987.…”

Section: Introductionmentioning

confidence: 99%

Comparative proteome analysis of peripheral neutrophils from sulfur mustard-exposed and COPD patients

Shahriary

Mehrani

Ghanei

et al. 2014

Journal of Immunotoxicology

Self Cite

View full text Add to dashboard Cite

Respiratory disorders in sulfur mustard (SM)-exposed and chronic obstructive pulmonary disease (COPD) patients are mostly associated with neutrophilic inflammation, severe airflow limitation, and oxidative stress. The objective of this study was to establish whether neutrophil (PMN) proteomes in these diseases were similar or differed. Blood neutrophil proteomes from healthy, SM-exposed, and COPD subjects were analyzed using two-dimensional gel electrophoresis followed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI TOF MS). Elastase activity was determined kinetically. The results showed that levels of S100 calcium-binding protein (CBP) A12, S100 CBP A8, glyceraldehyde-3-phosphate dehy-drogenase, superoxide dismutase, and protein disulfide isomerase proteinsas well as elastase activity -were significantly increased in PMN from 'diseased' hosts compared to in cells from healthy controls. In contrast, coactosin-like protein, RhoGDP dissociation inhibitor, and actin isoforms were significantly decreased in diseased subjects' PMN compared to PMN of healthy controls. Moreover, serpin B1 and coronin-1A were expressed only in PMN of the healthy subjects. Lastly, S100 CBP A9, endoplasmic reticulum (ER)-60 protease, and glutathione-S-transferase isoforms were differentially expressed in the cells from the SMexposed and COPD subjects. These results show that serpin B1, an efficient inhibitor of neutrophil serine proteases, was not detectable, and elastase activity significantly increased in PMN from both SM-exposed and COPD patients. It seems that, apart from inflammation and oxidative stress, a protease:anti-protease imbalance exists within PMN of both COPD and SM-exposed patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparative proteome analysis of peripheral neutrophils from sulfur mustard-exposed and COPD patients

Shahriary

Mehrani

Ghanei

et al. 2014

Journal of Immunotoxicology

Self Cite

View full text Add to dashboard Cite

show abstract

“…One possible explanation for the observed clinical results may be due to long term side-effects of poisoning, reported by other investigators, which include severe respiratory complications and the resulting oxygenation disorder that may ensue (5,14,15). Therefore, it is expected for the victims to develop polycythemia, to compensate for the hypoxemia, but according to previous studies, this type of manifestation, which can be caused by destruction of RBCs, was not noted.…”

Section: Discussionmentioning

confidence: 82%

Relationship Between Serum Bilirubin Concentration and Inflammatory Cytokines in Victims Exposed to Sulfur Mustard

Nadoushan¹,

Mahdavi²,

Soroush³

et al. 2016

Trauma Mon

View full text Add to dashboard Cite

Background: Despite observed post Sulfur Mustard (SM) exposure hemolysis, serum bilirubin concentration does not significantly increase in SM-exposed casualties. The concentration of serum bilirubin can be related to serum levels of inflammatory cytokines. Objectives: In this study, the relationship between the serum levels of Interleukin (IL)-1α, IL-1β, IL-1Ra, Tumor Necrotizing Factor (TNF)-α and IL-6 with serum bilirubin concentration was investigated. Methods: Overall, 368 individuals, who were exposed to SM in 1986, and 127 non-exposed control participants were studied in the context of hematological factors, serum bilirubin and inflammatory cytokines. Total serum bilirubin and direct bilirubin were analyzed using an enzymatic method, while the inflammatory cytokines were evaluated by enzyme linked immunosorbent assay (ELISA). Results:The concentration of inflammatory cytokines in the exposed group was significantly different compared to the control group, however the serum concentrations of total and direct bilirubin did not differ between the two groups. Among cytokines, other than the relationship between the IL-6 concentrations and bilirubin level, there were no significant correlations between the levels of other cytokines with direct and total bilirubin. Conclusions: Considering the lack of correlation between bilirubin concentrations and levels of inflammatory cytokines other than IL-6, we should identify other confounding factors for lack of increase in bilirubin in SM casualties, despite the observed hemolysis.

show abstract

“…Approximately 95% are males who were between 17 and 30 y of age at the time of exposure. 3 The subjects enrolled in this study had severe obstructive pulmonary disease referred to as mustard airway disease, a late complication of mustard gas exposure. Previous pathological and radiological studies have shown bronchiolitis obliterans 4,5 to be the main airway disease in mustard gas-exposed cases, and imaging studies also indicated other airway diseases such as bronchiectasis, tracheobronchomalacia, and tracheobronchial stenosis.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Ventilation in Mustard Airway Diseases

2015

View full text Add to dashboard Cite

BACKGROUND: Noninvasive ventilation (NIV) has been shown to improve numerous clinical measures in subjects with COPD, including gas exchange, exercise tolerance, dyspnea, hospitalizations, health-related quality of life (HRQOL), and functional status. Although useful for classical COPD, NIV has not been validated specifically as a treatment option for mustard airway disease. Our aim was to assess the efficacy of NIV in subjects with severe mustard airway disease. METHODS: This study was performed over the course of 12 months on 20 subjects with severe mustard airway disease (Global Initiative for Chronic Obstructive Lung Disease criteria). Subjects were selected from the pulmonary clinic of Baqiyatallah Hospital in Tehran, Iran. Body mass index, lung function, dyspnea, exercise tolerance, HRQOL, sleep quality, and hospitalization measures were assessed before and after NIV treatment. RESULTS: NIV improved HRQOL (P ‫؍‬ .03) and sleep quality (P ‫؍‬ .06) in very severe subjects and reduced hospitalizations (P ‫؍‬ .003) and exacerbations (P ‫؍‬ .01) in severe subjects. Chest imaging studies showed that these subjects had heterogeneous airway disease, the main finding of which was bronchiolitis obliterans. CONCLUSIONS: NIV can be used as an effective new palliative method in the treatment of mustard airway disorders.

show abstract

Incidence of Lung, Eye, and Skin Lesions as Late Complications in 34,000 Iranians With Wartime Exposure to Mustard Agent

Cited by 290 publications

References 30 publications

Comparative proteome analysis of peripheral neutrophils from sulfur mustard-exposed and COPD patients

Comparative proteome analysis of peripheral neutrophils from sulfur mustard-exposed and COPD patients

Relationship Between Serum Bilirubin Concentration and Inflammatory Cytokines in Victims Exposed to Sulfur Mustard

Noninvasive Ventilation in Mustard Airway Diseases

Contact Info

Product

Resources

About