Incidence of hypothyroidism after treatment for breast cancer: A Korean population-based study

Abstract

This Korean population-based study aimed to describe the patterns of hypothyroidism after adjuvant radiation therapy (RT) in patients with breast cancer. The Korean Health Insurance Review and Assessment Service database was searched for patients with invasive breast carcinomas. We calculated the cumulative incidence and incidence rates per 1,000 person-years of subsequent hypothyroidism and compared them using the log-rank test and the Cox proportional hazards model. Between 2007 and 2018, 117,135 women diagnosed with breast cancer with a median follow-up time of 4.6 years were identified. The 8-year incidence of hypothyroidism was 9.3% in patients treated with radiation and 8.6% in those treated without radiation (p = 0.002). The incidence rates per 1,000 person-years in the corresponding treatment groups were 6.2 and 5.7 cases, respectively. The hazard ratio (HR) in patients receiving RT was 1.081 (95% confidence interval [CI], 1.013–1.134; p = 0.002). After mastectomy, RT showed a trend toward a higher risk of hypothyroidism (HR = 1.248; 95% CI, 0.977–1.595; p = 0.076). Our study provides one of the largest population-based data analyses regarding the risk of hypothyroidism among Korean patients with breast cancer. The adjusted risk for patients treated with RT exceeded that for patients with breast cancer treated without RT. The effect was evident immediately after treatment and lasted up to approximately 9 years.

A Evaluation Result of Treatment Plans Used In the Treat of Right Breast Tumors After Mastectomy

“…The IMRT technique represent good option for CB sparing compare with VMAT. Patients treated with RT for breast cancer had a higher risk of developing hypothyroidism that persisted for years after treatment ended (Park et al, 2022). Based on the results of this study and the previous one .…”

Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States

“…Clinical studies have reported alteration in TH levels [ 46 , 47 ] as well as shrinkage in thyroid gland size [ 78 ] in patients undergoing or following chemotherapy. Moreover, THs can enhance the efficacy of chemotherapy [ 79 ].…”

“…Among cancer survivors, cancer treatment-associated cardiotoxicity is a leading cause of treatment-related morbidity and mortality. In addition, studies have reported alteration in TH levels associated with cancer chemotherapy [ 46 , 47 ].…”

Hypothyroidism evaluation after radiotherapy of breast and supraclavicular in patients with breast cancer

“…Park et al . [ 13 ] investigated the incidence of HT after RT of about 117135 Korean BC patients with a follow-up time of 4 to 8 years. For patients treated with RT the rate of HT at 1, 5, and 8 years were 1.4, 6.2, and 9.3%, respectively, and for patients treated without RT were 1.2, 5.5, and 8.6%, respectively.…”