Incidence of Hypertension in Individuals with Abdominal Obesity in a Rural Japanese Population: The Tanno and Sobetsu Study

Ohnishi, Hirofumi; Saitoh, Shigeyuki; Akasaka, Hiroshi; Mitsumata, Kaneto; Chiba, M; Furugen, Makoto; Furukawa, Tetsuaki; Mori, Mitsuru; Shimamoto, Kazuaki

doi:10.1291/hypres.31.1385

Cited by 33 publications

(23 citation statements)

References 18 publications

(16 reference statements)

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“…In this study, however, the mean adiponectin level remained relatively high at 6.87± 0.56 μg/mL in the men with a visceral fat area of 151.9 cm 2 or greater and at 9.36±0.80 μg/mL in the women with a visceral fat area of 96.5 cm 2 or greater. The blood pressure increased in association with the visceral fat area, similar to the results of a study of Japanese subjects conducted by Ohnishi et al (14). The TG level exhibited a strong positive correlation and the HDLC level exhibited a negative correlation with the visceral fat area in both genders.…”

Section: Discussionsupporting

confidence: 88%

Relationships between the Visceral Fat Area on CT and Coronary Risk Factor Markers

Shiina

Homma

2013

Intern. Med.

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Objective The visceral fat area (VFA) was measured, and the relationships between the VFA and the body mass index (BMI), waist circumference, blood pressure, and indices of lipid and sugar metabolism were evaluated. Methods The subjects included 607 consecutive patients who underwent VFA examinations using computed tomography (CT) scans. In addition to the routine examination parameters, the levels of adiponectin and homeostasis model assessment as an index of insulin resistance (HOMA-IR) were measured in all subjects, and the levels of malondialdehyde-modified low-density lipoprotein (MDA-LDL), remnant-like particles (RLP), lipoprotein (a) (Lp(a)), apolipoprotein (Apo) AI, ApoB and ApoE were measured in 270 subjects. Results In both men and women, the VFA showed significant positive correlations with the age, BMI, waist circumference, subcutaneous fat area, visceral fat area/subcutaneous fat area (v/s) ratio, systolic blood pressure, diastolic blood pressure, the fasting blood sugar (FBS), the hemoglobin A1c (HbA1c), high-density lipoprotein cholesterol (HDLC), triglyceride (TG), uric acid, HOMA-IR and ApoB and the ApoB/LDLC ratio and significant negative correlations with the levels of HDLC and adiponectin. The levels of the total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), non-HDLC, MDA-LDL and Lp(a) and the ApoB/ ApoAI ratio were not correlated with the VFA in either men or women. The RLP exhibited a significant positive correlation with the VFA in women. Conclusion The VFA exhibited high positive correlations with the waist circumference, blood pressure and TG level and a negative correlation with the HDLC level, regardless of gender, supporting the validity of the present diagnostic method for evaluating metabolic syndrome (MS). Although the LDLC level is not included in the diagnostic criteria for MS, the positive correlations between the VFA and the ApoB level and ApoB/ LDLC ratio observed in both men and women indicate qualitative abnormalities of lipoproteins, such as an increase in the amount of small dense LDL. Measuring the levels of apolipoproteins in addition to lipoproteins during health screening is therefore useful for evaluating of atherogenicity.

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Section: Discussionsupporting

confidence: 88%

Relationships between the Visceral Fat Area on CT and Coronary Risk Factor Markers

Shiina

Homma

2013

Intern. Med.

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“…11 Moreover, it has also been reported that, if waist circumference is increased by 1 cm, the risk of the development of hypertension is increased by 2.49 times. 12 Accordingly, if waist circumference were to be reduced, even by 1 cm, it would be of medical significance for the prevention of obesity-related complications.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antiobesity Effects of an Amino Acid Mixture and Conjugated Linoleic Acid on Exercising Healthy Overweight Humans: A Randomized, Double-blind, Placebo-controlled Trial

Michishita

Kobayashi²,

Katsuya

et al. 2010

J Int Med Res

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This single-centre, randomized, doubleblind, placebo-controlled trial investigated the effects of administering a mixture of four amino acids (lysine, proline, alanine and arginine) with or without conjugated linoleic acid to healthy overweight humans before and after exercising. Fortyone healthy subjects (body mass index ≥ 23 to < 30 kg/m 2 ) completed the study following randomization to receive either placebo or one of three test supplements: amino acid mixture 0.76 g/day; amino acid mixture 1.52 g/day; or amino acid mixture 1.52 g/day coadministered with conjugated linoleic acid 1.6 g/day. Each of the study treatments was administered 30 min before and immediately after a period of daily exercise, which was delivered by an exercise expert, for a period of 12 weeks. When compared with the placebo group, several indicators, such as waist and hip circumferences, were found to have significantly decreased in the test supplement groups compared with the placebo. These results suggest that ingestion of these supplements might enhance the fat-burning effects of exercise.

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“…25 This notion was also confirmed in the Tanno and Sobetsu Study, a cohort study of the general population in the Hokkaido area, Japan. 28 Thus, it is possible that the cut-off point of 90 cm for females may have underdiagnosed central obesity in the Japanese population. This sex difference in the definition of abdominal obesity should be taken into consideration when evaluating the prevalence of MetS in the Japanese population using the Asian criteria of the IDF (90 cm for men and 80 cm for women).…”

Section: Study Limitationsmentioning

confidence: 99%

Prognostic Impacts of Metabolic Syndrome in Patients With Chronic Heart Failure　– A Multicenter Prospective Cohort Study –

Tadaki

Sakata

Miura

et al. 2016

Circ J

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Incidence of Hypertension in Individuals with Abdominal Obesity in a Rural Japanese Population: The Tanno and Sobetsu Study

Cited by 33 publications

References 18 publications

Relationships between the Visceral Fat Area on CT and Coronary Risk Factor Markers

Relationships between the Visceral Fat Area on CT and Coronary Risk Factor Markers

Evaluation of the Antiobesity Effects of an Amino Acid Mixture and Conjugated Linoleic Acid on Exercising Healthy Overweight Humans: A Randomized, Double-blind, Placebo-controlled Trial

Prognostic Impacts of Metabolic Syndrome in Patients With Chronic Heart Failure　– A Multicenter Prospective Cohort Study –

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Incidence of Hypertension in Individuals with Abdominal Obesity in a Rural Japanese Population: The Tanno and Sobetsu Study

Cited by 33 publications

References 18 publications

Relationships between the Visceral Fat Area on CT and Coronary Risk Factor Markers

Relationships between the Visceral Fat Area on CT and Coronary Risk Factor Markers

Evaluation of the Antiobesity Effects of an Amino Acid Mixture and Conjugated Linoleic Acid on Exercising Healthy Overweight Humans: A Randomized, Double-blind, Placebo-controlled Trial

Prognostic Impacts of Metabolic Syndrome in Patients With Chronic Heart Failure – A Multicenter Prospective Cohort Study –

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Prognostic Impacts of Metabolic Syndrome in Patients With Chronic Heart Failure　– A Multicenter Prospective Cohort Study –