Incidence of herpes genitalis in Northern Ireland in 1973-83 and herpes simplex types 1 and 2 isolated in 1982-4.

Abstract

During 1973 - 83 there was a pronounced rise in the number of new cases of herpes genitalis in Northern Ireland. This study of 127 patients with herpes genitalis shows that 30% had herpes simplex virus type 1 (HSV 1) and 70% had herpes simplex virus type 2 (HSV 2) infections. Of 41 sexual contacts who attended, only seven had herpes genitalis (caused in each case by HSV 2); another patient had a history of genital lesions, and one other of oral lesions, but HSV was not isolated from either patient. None of the other sexual contacts had a history of oral or genital infection. Of 31 women with herpes genitalis who consented to undergoing cervical cytology, five had atypical changes (all had primary herpes genitalis). Of these, four were infected with HSV 1 and one with HSV 2.

Seroepidemiological Study Of Herpes Simplex Virus Types 1 In Black Sea Region Of Turkey

“…When we compared the sexually inactive age group seropositivity with adult groups; sexually inactive age group seropositivity was higher, but not significantly different from adult females (59.9%), although significantly different from adult males (55.7%). The earlier increase in HSV-1 seroprevalence in women observed in this study reflects the higher risk of genitally acquired HSV-1 in young women (25)(26)(27)(28)(29)(30), which may reflect age-specific mixing patterns, with women having male partners on average older than themselves. The highest level, however, was determined in the sexually inactive age group.…”

Type Incidence of Herpes Simplex Virus in Clinical Isolates from Patients with Herpes Genitalis

“…HSV-1 was isolated more frequently in our patient population than has been reported from other places. 2,[6][7][8][9][10] In the present study, 56.5% of the isolates from patients (both males and females) in their first episode were HSV-1 and 43.5% contained HSV-2. This confirms the findings reported in a a small group of patients from Sheffield, England.…”

“…2 As mentioned previously, HSV-2 has been shown to be associated with cervical neoplasia, 18,19 and in a recent report, four of five patients with cervical atypia had herpes genitalis caused by HSV-1, which suggests that HSV-1 may play a role in the etiology of cervical neoplasia-perhaps as an initiator. 20 It is also important to take this finding into account when an HSV vaccine is produced for the prevention and control of herpes genitalis.…”

“…Thus HSV-1 has accounted for a widely different proportion of isolates from patients with first episodes of genital herpes, averaging 7% in Seattle, Washington, U.S., 30% in Northern Ireland, 43% in Japan, and 63% in Sheffield, England. 2,8,10,11 We report here the incidence of HSV-1 and HSV-2 in patients with first episode and recurrent genital HSV infection in Sheffield, England.…”

Rapid Detection of HSV from Cytologic Specimens Collected into ThinPrep Fixative

“…According to Lavery et al, 7 only 5 of 31 women with herpes genitalis showed viral changes on biopsy, indicating low sensitivity for detection of HSV on routine Papanicolaou smear. Likewise, a study performed by Cone et al 8 reported detection of HSV DNA several days after lesions became negative for infectious virus, thus making …”