Incidence, biochemical and haematological alterations induced by natural trypanosomosis in racing dromedary camels

Chaudhary, Z. I.; Iqbal, Jamshaid

doi:10.1016/s0001-706x(00)00142-x

Cited by 55 publications

(36 citation statements)

References 12 publications

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“…Increase in WBC counted in the QS with FCA group portrays the role of FCA in preventing cytodestruction of T lymphocytes and natural killer lymphocytes [14,19,24] thereby suggestive of the ability of FCA to enhance immune response via activation of immune cells to combat the effect of the trypanosome organism. Changes observed in ALT, AST, ALP and GGT were within normal range in all groups [25], which agrees with the reports of Chaudhary and Iqbal [26] and Guiterrierez et al [27], who argued that, organs (liver and kidney) may not have been seriously affected to cause the expected damage that results in leakage of these enzymes into the plasma.…”

Section: Discussionsupporting

confidence: 91%

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Therapeutic Efficacy of Quinapyramine Sulphate with Freund’s Complete Adjuvant in Wistar Rats Infected with Trypanosoma Congolense

Ehizibolo¹,

Karaye²,

Kadima³

et al. 2017

JPP

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Therapeutic efficacy of QS (quinapyramine sulphate) and FCA (Freund's complete adjuvant) combination was studied. The aim of the study was to evaluate therapeutic efficacy of QS using FCA in Trypanosoma congolense infection. Groups treated with QS and FCA had parasite disappeared in peripheral circulation 2 days pi, relapse was observed one week later. Effect of treatment on rectal temperature shows no significance (p < 0.05), normalization of rectal temperature occurred in QS and FCA treated groups (34. with untreated and other groups. There was comparative decrease in serum liver enzymes in QS and FCA treated group than other groups. Therefore, QS at lower recommended dose with FCA may enhance efficacy of QS in trypanosomiasis.

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Section: Discussionsupporting

confidence: 91%

“…Twenty five (25) Wistar rats weighing 189 ± 5 grams were used in this study. The rats were obtained from the animal house of the National Institute for Trypanosomiasis and Onchocerchiasis Research (NITOR), Vom, Nigeria.…”

Section: Experimental Animalsmentioning

confidence: 99%

Therapeutic Efficacy of Quinapyramine Sulphate with Freund’s Complete Adjuvant in Wistar Rats Infected with Trypanosoma Congolense

Ehizibolo¹,

Karaye²,

Kadima³

et al. 2017

JPP

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“…Significant decrease (P<0.05) in RBC, Hb, PCV and lymphocyte count was observed by Chaudhary and Iqbal. They also recorded significant (P<0.05) increase in WBC and neutrophils in natural Trypanosomiasis in racing dromedary camels in their studies [16]. Leucopaenia in animal Trypanosomiasis has been reported to be due largely to ineffective or depressed granulopoiesis in the bone marrow [17].…”

Section: Resultsmentioning

confidence: 90%

Haematological changes in Trypanosoma evansi infected cattle

Sivajothi

Reddy²,

Kumari³

et al. 2014

International Journal of Scientific World

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During the three years period of study twelve cross bred cattle were identified that they were suffering with clinical Trypanosomiasis. Up on clinical examination cattle had anorexia, fever, ocular discharges, dullness and enlarged lymph nodes. Stained peripheral blood examination revealed the presence of Trypanosoma evansi. Haematological abnormalities include decreased TEC, PCV, Hb and TLC values (P<0.01). The present leucopaenia was characterized by neutrophilia, eosinophilia and lymphocytopaenia (P>0.05).

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“…The decline in albumin could also be due to the initiation of the immune response and synthesis of immunoglobulins as well as to a probable haemodilution (Katunguka-Rwakishaya et al, 1992;Anosa and Isoun, 1976). A significantly lower level of albumin has also been reported in T. evansi-infected camels whilst no alterations of urea and total protein concentration were noticed (Chaudhary and Iqbal, 2000). During our study, supplemented does had higher plasma TP and albumin levels than females receiving a basal diet whereas Osaer et al (2000) found no effect of diet on the plasma concentrations of these parameters.…”

Section: Biochemical Changesmentioning

confidence: 96%

Influence of an experimental Trypanosoma congolense infection and plane of nutrition on milk production and some biochemical parameters in West African Dwarf goats

et al. 2005

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The interactions of trypanosomosis and plane of nutrition on health and productivity of multiparous and primiparous West African Dwarf (WAD) does were studied in a multifactorial experiment including diet (supplementation or basal diet) and infection (infected or control). Experimental does were infected with Trypanosoma congolense at the beginning of the second week post-kidding and monitored for 16 weeks after infection. Trypanosome infection significantly reduced PCV (control: 30.1 ± 0.3 % vs infected: 22.2 ± 0.3 %; P < 0.0001). Regardless of infection, the drop in PCV from the pre-infection period to the end of the experiment was more severe in animals under restricted diet (interaction diet * period: P < 0.001). Trypanosome parasitaemia tended to be higher in the supplemented group than in the basal diet group (P > 0.05) and multiparous animals had a higher parasitaemia (score: 2.6 ± 0.1) than primiparous animals (score: 2.2 ± 0.1) (P < 0.05). Trypanosome infection as well as dietary supplement had a significant effect on lactation length. Milk off-take from trypanosome-infected does was significantly lower than that from the uninfected control group (17.5 ± 3.2 l vs 35.5 ± 3.2 l, P < 0.001) and there was a positive effect of plane of nutrition (supplemented: 32.8 ± 3.2 l and basal diet: 20.2 ± 3.5 l, P = 0.01). The drop in milk off-take due to trypanosome infection was more severe in the supplemented group (control: 46.7 ± 4.7 l vs infected: 18.9 ± 4.2 l) than in the group receiving a basal diet (control: 24.2 ± 5.0 l vs infected: 16.1 ± 4.7 l) (interaction infection *diet, P = 0.04) due to the number of does from the supplemented group that were withdrawn from the experiment. The effect of trypanosome infection on doe's live-weight was only noticeable during the first 8 weeks of lactation and there was no significant effect on offspring growth rate unless the mother died.Plasma total protein, albumin and cholesterol concentrations were significantly reduced by the infection but were significantly increased by supplementation. Supplemented does had a higher level of cholesterol and a tendency for a higher parasitaemia. Does of high parity also had a higher cholesterol level than primiparous does and, based on the number of animals that were withdrawn from the experiment, they showed a lower resistance to the infection.

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Incidence, biochemical and haematological alterations induced by natural trypanosomosis in racing dromedary camels

Cited by 55 publications

References 12 publications

Therapeutic Efficacy of Quinapyramine Sulphate with Freund’s Complete Adjuvant in Wistar Rats Infected with Trypanosoma Congolense

Therapeutic Efficacy of Quinapyramine Sulphate with Freund’s Complete Adjuvant in Wistar Rats Infected with Trypanosoma Congolense

Haematological changes in Trypanosoma evansi infected cattle

Influence of an experimental Trypanosoma congolense infection and plane of nutrition on milk production and some biochemical parameters in West African Dwarf goats

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