Incidence and survival of oropharyngeal cancer in Denmark: a nation-wide, population-based study from 1980 to 2014

Jensen, Jan H.; Jensen, David Hebbelstrup; Grønhøj, Christian; Karnov, Kirstine; Nørregaard, Cecilie; Agander, Tina Klitmøller; Specht, Lena; Buchwald, Christian von

doi:10.1080/0284186x.2017.1390251

Cited by 24 publications

(14 citation statements)

References 17 publications

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“…Studies have shown that survival in head and neck cancer has improved during the last years but in this study we did not observe a significant increase in survival in the period 1980-2014 for laryngeal cancer [25][26][27]. Reason for the missing improvement in survival could be that survival for laryngeal cancer is already very good compared to other head and neck cancers as laryngeal cancers are detected at very early stages and risk of regional metastasis is very low due to lack of lymphoid drainage from the vocal cords [28].…”

Section: Discussioncontrasting

confidence: 71%

Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014

et al. 2019

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Background: The purpose of this registry study was to evaluate trends in incidence and survival of laryngeal cancer in the Danish population from 1980 to 2014. Methods: This study includes all patients with laryngeal cancer registered in the Danish Cancer Registry (DCR) in the period 1980-2014. The age-adjusted incidence rate (AAIR) per 100,000 and average annual percent change (AAPC) were calculated. We evaluated the relative survival at five years in relation to gender, anatomical location, year at diagnosis, and histological type. Further, an ageperiod-cohort (APC) model of incidence was constructed. Results: A total of 8748 patients (82% males) were included. The median age at diagnosis was 60 years, range 18-101 years. The AAIR decreased from 3.6 per 100,000 in 1980 to 2.3 per 100,000 in 2014 with an AAPC of-0.8% (p < .008). Considering the anatomic location, we found that glottic cancer had a significantly better survival at five years compared to the other locations. We observed no significant difference in survival for supraglottic, subglottic and larynx unspecified cancer during the observation period. During the period 1980-2014, we found no improvement in five year relative survival. Conclusions: This nationwide study reports a significant decrease in the incidence of laryngeal cancer. Glottic cancer had a significantly better survival at five years compared to other locations.

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Section: Discussioncontrasting

confidence: 71%

Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014

et al. 2019

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“…This might be a result of the highly significant age effect for women. The cohort effect, with a decrease in the years leading up to, and following 1940, should also be noted, as this also has been observed in prior reports for head and neck cancer 27,28…”

Section: Discussionsupporting

confidence: 66%

<p>The Copenhagen Oral Cavity Squamous Cell Carcinoma database: protocol and report on establishing a comprehensive oral cavity cancer database</p>

Jensen¹,

Jakobsen²,

Mirian³

et al. 2019

CLEP

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ObjectiveThe aim was to establish a large comprehensive database of patients with oral cavity squamous cell carcinoma (OSCC) to enable surveillance and research of the disease.MethodsAll patients diagnosed and/or treated for OSCC at Rigshospitalet, University of Copenhagen, Denmark in the period 2000–2014 were included. Rigshospitalet is a tertiary treatment center and covers the Eastern Denmark region, comprising nearly half of the approximately 5.8 million inhabitants of Denmark. Data on numerous variables regarding general information of the patients at diagnosis, their primary cancer, recurrence, treatment, prior cancers, and secondary cancers were collected from the Danish Pathology Register and by evaluation of medical charts.ResultsOne thousand three hundred and ninety-nine OSCC patients were included in the database (62% males). The median age at diagnosis was 63 years (range: 23–99 years). The most common anatomical location was the floor of mouth (38%). Among patients with known stage, 70.0% were diagnosed in T-stage 1 or 2 and 64.9% were diagnosed in N-stage 0. Most patients were treated with primary surgery (81.7% among patients with known treatment), of these 44% received adjuvant radiotherapy after surgery. The overall age-standardized incidence of OSCC per 100,000 increased from 2.15 in 2000 to 3.04 in 2014, with a significant annual percent change of 3.2%.ConclusionWe have established a consecutive, population-based database of 1,399 OSCC patients. This creates a basis for multiple studies that will elaborate our understanding of OSCC, and hopefully improve diagnosis, treatment, and rehabilitation of OSCC patients.

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“…This does not match other studies, where it has been reported that OPCs have a relatively poor prognosis, as they are often diagnosed at an advanced stage [1]. However, studies have found that the survival for OPCs is increasing [36] and that patients with HPVpositive OPC have better survival and a lower risk of recurrence than HPV-negative OPC [37]. Our results also showed that OPC was diagnosed at a significantly earlier stage (stage I-II).…”

Section: Discussioncontrasting

confidence: 99%

Incidence and survival of head and neck cancer in the Faroe Islands

Olsen

Friborg

Ellefsen

et al. 2021

International Journal of Circumpolar Health

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Background: The Faroese people constitute a geographically isolated population, and research on cancer in this population is sparse. Thus, this study aimed to calculate the age-standardised incidence rate (ASIR) and 5-year survival rates in head and neck cancers (HNC) in the Faroese population from 1985 to 2017. Materials and methods: All patients registered with HNC in the Faroese Cancer Registry (FCR) from 1985 to 2017 were included. The ASIR per 100,000 (World Standard Population) and 5-year survival rates were calculated. We also calculated the distribution of tobacco, alcohol consumption, cancer stages and various timelines. Results: 202 patients were included in the study (62% men). The ASIR for all HNC was 10.0/ 100,000 persons-years and was higher among men than women. Women's survival rate was significantly higher than men's (p = 0.026). The results imply that oropharyngeal cancer (OPC) had the best survival rate and was diagnosed at a significantly earlier stage. Conclusion: This retrospective nationwide study showed that ASIRs and 5-year survival rates for Faroese HNC patients in general resembled the ones reported for Danish HNC patients. Timelines for Faroese HNC patients were shorter compared with Greenlandic HNC patients, but longer compared with the Danish fast track programme limits.

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Incidence and survival of oropharyngeal cancer in Denmark: a nation-wide, population-based study from 1980 to 2014

Abstract: In this population-based study, we observed a significant increase in the incidence of OPCs and in the RS for OPC. We also identified a profound birth cohort effect on the incidence.

Cited by 24 publications

References 17 publications

Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014

Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014

<p>The Copenhagen Oral Cavity Squamous Cell Carcinoma database: protocol and report on establishing a comprehensive oral cavity cancer database</p>

Incidence and survival of head and neck cancer in the Faroe Islands

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