Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014

Nahavandipour, Arvin; Jakobsen, Kathrine Kronberg; Grønhøj, Christian; Jensen, David Hebbelstrup; Karnov, Kirstine; Agander, Tina Klitmøller; Specht, Lena

doi:10.1080/0284186x.2019.1572923

Cited by 38 publications

(29 citation statements)

References 21 publications

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“…Concurrent chemoradiation has become the dominant treatment for advanced laryngeal cancer because of its higher rates of organ preservation compared to radiation therapy (RT) alone or induction chemotherapy followed by RT (5,6). Despite the increasing use of chemotherapy and radiotherapy combinations in the majority of patients with advanced cancer, no improvement in overall survival has been found (5,7,8). Total laryngectomy is used to treat locally recurrent disease after chemoradiotherapy, especially for older or frail patients (6,9).…”

Section: Introductionmentioning

confidence: 99%

Impact of Prior Cancer on the Prognosis of Patients With Laryngeal Cancer: A Population-Based Study Using the Surveillance, Epidemiology, and End Results Database

Chen

Tian

et al. 2020

Front. Oncol.

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Background: Little is known about the clinical significance of laryngeal cancer as a subsequent tumor. We aimed to determine the impact of a prior cancer history on the prevalence and prognosis of patients with laryngeal cancer. Methods: We retrospectively reviewed patients diagnosed with laryngeal cancer between 2004 and 2011 in the Surveillance, Epidemiology, and End Results (SEER) database. The t-test and chi-squared test were used to compare variables as appropriate. Matched 1:1 case control-adjusted Kaplan-Meier analyses and Cox regression models were performed to investigate the impact of prior cancer on overall survival (OS). Results: Among 20,987 patients with laryngeal cancer, nearly one-fifth (n = 3,915, 18.65%) had a prior cancer. The top three common prior cancers were prostate (588, 28.1%), lung and bronchus (354, 16.9%), and head and neck (306, 14.6%). A total of 73.4% of the prior cancers were diagnosed within 5 years of the laryngeal cancer diagnosis. Compared to patients without prior cancer, a worse survival was significantly associated with a prior cancer among laryngeal cancer patients, regardless of the interval time of the prior cancer (log-rank tests P < 0.001). Furthermore, prior cancer was an independent predictor of worse OS based on the Cox regression model [hazard ratio (HR) = 1.396, 95% confidence interval, 1.336-1.458]. In addition, patients with prior lung and bronchus cancer tended to have the worst survival (log-rank tests P < 0.001). Conclusions: Prior cancer has an adverse effect on clinical outcomes among patients with laryngeal cancer. These results suggest that individualized treatment should be seriously considered in patients with laryngeal cancer and a history of prior cancer, regardless of the interval time of prior cancer.

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Section: Introductionmentioning

confidence: 99%

Impact of Prior Cancer on the Prognosis of Patients With Laryngeal Cancer: A Population-Based Study Using the Surveillance, Epidemiology, and End Results Database

Chen

Tian

et al. 2020

Front. Oncol.

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“…Glottic cancer is the most common form of laryngeal cancer 39 . The annual number of cases diagnosed with glottic cancer in Denmark in the period 2000-2009 was approximately 139 and the corresponding incidence 2.6 per 100,000 persons 40 .…”

Section: Discussionmentioning

confidence: 99%

Incidence and malignant transformation of glottic precursor lesions in Denmark

Sannino

Mehlum²,

Grøntved³

et al. 2020

Acta Oncologica

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Objectives: Glottic precursor lesion (GPL) is a well-known premalignant condition, but the existing knowledge of incidence and malignant potential is based on subpopulation studies. In this first nationwide study we report data from all verified cases of GPL in Denmark during a 10-year period with focus on incidence and malignant transformation of GPL.Methods: Patients were identified by a search for GPL in the time period from 01.01.2000 to 31.12.2009 using the Danish Pathology Data Base, Patobank, which is a nationwide source of all cyto-and histopathological data obtained in Denmark. Data were validated and supplemented by medical chart review.Results: A 10-year national cohort of 965 patients (median age 60 years, male-female ratio 2:1) with histologically verified GPL was analyzed. The overall malignant transformation rate was 18.3 % (mild dysplasia 7.7%, moderate dysplasia 19.8%, severe dysplasia 28.5%, and carcinoma in situ 40.3%) with a median progression time of 29 months. Eighty-eight percent of patients were active or former smokers. A significantly larger proportion of male patients (24.1 %) experienced malignant transformation compared to females (6.6%) (p<0.001). Conclusion:This nationwide population-based study of GPL patients confirmed a stable incidence of GPL in Denmark from January 2000 to December 2009 and a considerable malignant potential, correlated to the grading of GPL according to the World Health Organization classification of laryngeal precursor lesions from 2005, WHOC2005. The recent update, WHOC2017, of low-grade versus high-grade lesions may thus contain less nuanced prognostic information than WHOC2005.

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“…Laryngeal squamous cell carcinoma (SCC) is one of the most common types of head and neck cancer with a global incidence of over 170 000 patients per year, resulting in almost 95 000 deaths in 2018 1 . Despite recent advances in treatment the 5‐year overall survival has not changed significantly over the past 20 years 2‐5 …”

Section: Introductionmentioning

confidence: 99%

The value of narrowband imaging using the Ni classification in the diagnosis of laryngeal cancer

Ahmadzada

Tseros

Sritharan

et al. 2020

Laryngoscope Investig Oto

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Introduction Narrowband imaging (NBI) is a special endoscopic optical enhancement setting allowing better visualization of mucosal microvasculature compared to white light endoscopy. This study evaluates the validity of NBI using the Ni classification in the detection and differentiation of severe dysplasia (SD) and glottic squamous cell carcinoma (SCC). Methods Patients with suspicious vocal cord lesions underwent conventional white light endoscopy followed by clinically indicated biopsy. At the same time, NBI images were obtained and graded independently. Lesions were graded from I to V according to the Ni classification and compared to histopathological findings. Results Fifty‐two patients were included in this study (40 SCC and 12 SD). The sensitivity and specificity of NBI in diagnosing laryngeal cancer was 95.0% (CI, 83.9%‐99.4%) and 83.3% (CI, 51.6%‐97.9%), respectively. The negative likelihood ratio was 0.06. Higher Ni grades correlated very strongly with more advanced disease. Conclusions NBI using the Ni classification is a sensitive diagnostic tool for the detection and differentiation of early neoplastic and preneoplastic glottic lesions. As higher Ni classification correlates strongly with advanced disease, it serves as a useful adjunct to white light endoscopy in the diagnosis of laryngeal cancer. Level of Evidence: Level IV.

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Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014

Cited by 38 publications

References 21 publications

Impact of Prior Cancer on the Prognosis of Patients With Laryngeal Cancer: A Population-Based Study Using the Surveillance, Epidemiology, and End Results Database

Impact of Prior Cancer on the Prognosis of Patients With Laryngeal Cancer: A Population-Based Study Using the Surveillance, Epidemiology, and End Results Database

Incidence and malignant transformation of glottic precursor lesions in Denmark

The value of narrowband imaging using the Ni classification in the diagnosis of laryngeal cancer

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