<p>The Copenhagen Oral Cavity Squamous Cell Carcinoma database: protocol and report on establishing a comprehensive oral cavity cancer database</p>

Abstract

ObjectiveThe aim was to establish a large comprehensive database of patients with oral cavity squamous cell carcinoma (OSCC) to enable surveillance and research of the disease.MethodsAll patients diagnosed and/or treated for OSCC at Rigshospitalet, University of Copenhagen, Denmark in the period 2000–2014 were included. Rigshospitalet is a tertiary treatment center and covers the Eastern Denmark region, comprising nearly half of the approximately 5.8 million inhabitants of Denmark. Data on numerous variables regarding general information of the patients at diagnosis, their primary cancer, recurrence, treatment, prior cancers, and secondary cancers were collected from the Danish Pathology Register and by evaluation of medical charts.ResultsOne thousand three hundred and ninety-nine OSCC patients were included in the database (62% males). The median age at diagnosis was 63 years (range: 23–99 years). The most common anatomical location was the floor of mouth (38%). Among patients with known stage, 70.0% were diagnosed in T-stage 1 or 2 and 64.9% were diagnosed in N-stage 0. Most patients were treated with primary surgery (81.7% among patients with known treatment), of these 44% received adjuvant radiotherapy after surgery. The overall age-standardized incidence of OSCC per 100,000 increased from 2.15 in 2000 to 3.04 in 2014, with a significant annual percent change of 3.2%.ConclusionWe have established a consecutive, population-based database of 1,399 OSCC patients. This creates a basis for multiple studies that will elaborate our understanding of OSCC, and hopefully improve diagnosis, treatment, and rehabilitation of OSCC patients.

Correlation of histopathological patterns of OSCC patients with tumor site and habits

“…In the present study, patients demonstrated ages ranging from 28 to 75 years, in which most of the cases were seen in the fifth decade. The mean age of patients reported in our study is 48.33, according to the results of other several South Asian studies [ 17 – 19 ], yet in contrast to findings from the European studies [ 1 , 22 , 23 ], where the mean age at diagnosis was 63 years. This indicates that there is a rising incidence of the younger age group in South Asia as there is greater exposure to risk habits.…”

“…Oral squamous cell carcinoma is the most frequently occurring carcinoma of the head and neck. Every year 2.5% of all newly reported carcinoma cases are of OSCC while the death rate is 1.9% [ 1 ].…”

Head and neck cancer patients’ recollection of their clinical characteristics

“…Accurate data is essential when reporting treatment outcomes. For some countries large datasets exist; for example German-Austrian-Swiss Cooperative Group on Tumours of the Maxillofacial Region (DÖSAK), 1 Danish Head and Neck Cancer Group (DAHANCA), 2 National Cancer Database, 3 US population using Surveillance, Epidemiology, and End Manuscript with title (excluding any author details including names and affiliations) Click here to view linked References Results (SEER), 4 whilst other centres collect regional data related to their unit such as Copenhagen, 5 and Liverpool. 6 Accurate data is more difficult to maintain for regional centres as they have a wider geographic referral base into the centre and follow-up tends to be in the patients locality.…”

Close relationship between TAZhigh/SOX2high co-localization and metastasis in oral squamous cell carcinoma

“…Oral cancer is one of the most common cancers in the world with poor prognosis and without specific biomarkers for disease [1,2]. The global incidence of oral squamous cell carcinoma (OSCC) is approx-imately 300,000 new cases per year [3].…”

“…The global incidence of oral squamous cell carcinoma (OSCC) is approx-imately 300,000 new cases per year [3]. The high mortality is closely associated with the presence of metastases and high rate of recurrence [1,2,3]. There is growing evidence which indicates that oncogenically transformed stem cells -cancer stem cells (CSCs) may be associated with the biological features of oral cancer such as the rapid growth, invasion, metastases, recurrence and resistance to treatment [4,5].…”