Incidence and risk factors for venous thrombosis among patients with inflammatory bowel disease in China: a multicenter retrospective study

Liu, Jing; Gao, Xiang; Chen, Ye; Qiao, Mu; Zhu, Liangru; Qian, Jiaming; Hu, Pinjin; Cao, Qian

doi:10.5217/ir.2020.00017

Cited by 8 publications

(5 citation statements)

References 36 publications

(99 reference statements)

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“…We identified an additional 13 during the screening of the reference sections of the included studies. Eighteen studies met inclusion criteria; 17 of the included studies were retrospective cohort studies ( 22 , 24 – 32 , 34 , 35 , 42 – 47 ), one of the included studies was a case-control study ( 48 ) ( Figure 1 ). The data was extracted in a tabular format and has been summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Risk Factors of Venous Thromboembolism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Zhang

Wang

2021

Front. Med.

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Background: Patients suffering from chronic inflammatory disorders, such as inflammatory bowel disorder, are at higher risk of developing thromboembolism. The chronic inflammatory nature of inflammatory bowel disease has been identified as a predominant reason for a state of Virchow's triad (i.e., endothelial dysfunction, stasis, and general hypercoagulability), eventually leading to the onset of venous thromboembolism. Recent studies show that certain factors, such as demographics, medication history, and history of surgical intervention may increase thromboembolism risk in patients with inflammatory bowel disease. However, to date, no study has attempted to evaluate the effect of different risk factors associated with the development of venous thromboembolism in inflammatory bowel disease patients.Objective: To evaluate the risk factors that can influence the incidence of venous thromboembolism in patients with inflammatory bowel disease.Methods: Academic literature was systematically searched based on the PRISMA guidelines across five databases: Web of Science, EMBASE, CENTRAL, Scopus, and MEDLINE. A random-effect meta-analysis was conducted to evaluate the hazard ratio for the risk factors (i.e., aging, gender, steroid therapy, surgery, and ulcerative colitis) that can influence the incidence of venous thromboembolism in patients with inflammatory bowel disease.Results: From a total of 963 studies, 18 eligible studies with 1,062,985 (44.59 ± 10.18 years) patients suffering from inflammatory bowel disease were included in the review. A meta-analysis revealed a higher risk of aging (Hazard's ratio: 2.19), steroids (1.87), surgery (1.48), and ulcerative colitis (2.06) on venous thromboembolism in patients with inflammatory bowel disease. We also found that the female gender (0.92) did not increase the incidence of venous thromboembolism in inflammatory bowel disease patients.Conclusion: The study provides preliminary evidence regarding high risks associated with ulcerative colitis, steroid consumption, and aging for the development of venous thromboembolism in patients with inflammatory bowel disease. The findings from this study may contribute to developing awareness among clinicians, better risk stratification and prevention of venous thromboembolic complications in patients with inflammatory bowel disease.

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Section: Resultsmentioning

confidence: 99%

Risk Factors of Venous Thromboembolism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Zhang

Wang

2021

Front. Med.

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“… 40 , 42 - 44 Several risk factors are more common in IBD patients than in the general population, including hyperhomocysteinemia, dehydration, infection, prolonged immobilization, and active intestinal disease. 40 , 42 , 45 In addition, the risk of VTE in IBD patients may increase when it is accompanied by other diseases known to be risk factors for VTE. This hypothesis is supported by the fact that the HR value for VTE gradually increased with CCI score in this study.…”

Section: Discussionmentioning

confidence: 99%

Venous Thromboembolism Risk in Asian Patients with Inflammatory Bowel Disease: A Population-Based Nationwide Inception Cohort Study

et al. 2021

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Background/Aims Inflammatory bowel disease (IBD) is associated with the occurrence of venous thromboembolism (VTE). However, to date, there have been few studies on the risk of VTE in Asian IBD patients. We aimed to estimate the incidence of VTE in Asian IBD patients and to determine if IBD is related to increased VTE risk. Methods We performed a population-based cohort study between 2004 and 2015 using Korean National Health Insurance data. IBD and VTE were defined by ICD-10 codes. Incidence rates of VTE were calculated among patients with IBD and among age- and sex-matched controls. Hazard ratios were estimated using Cox regression with adjustment for multiple variables. We performed additional analyses stratifying by age, sex, Charlson comorbidity index (CCI) score, and disease type. Results Among the 45,037 patients with IBD (IBD cohort) and 133,019 matched controls (non-IBD cohort) included in our analysis, 411 IBD patients and 641 controls developed VTE. The IBD cohort had a higher incidence rate ratio and risk of VTE than the non-IBD cohort (incidence rate ratio 1.92 and hazard ratio 1.93). Older age, female sex, higher CCI scores, cardiovascular disease, chronic kidney disease, use of steroids, and hospitalization were significant risk factors for VTE in patients with IBD. Conclusions The IBD patients in this study were approximately two times more likely to develop VTE than the non-IBD individuals. Our findings support the need for thromboprophylaxis in Asian IBD patients with various factors that further increase the risk of VTE.

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“…One study 87 has shown that the incidence of venous thrombosis in IBD patients in China is 41.45/100 000. Numerous studies [88][89][90][91] have reported that the risk of thrombosis increases at the active stage of severe UC.…”

Section: Thromboprophylaxis and Treatmentmentioning

confidence: 99%

Chinese consensus on diagnosis and treatment in inflammatory bowel disease (2018, Beijing)

2021

J of Digest Diseases

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Incidence and risk factors for venous thrombosis among patients with inflammatory bowel disease in China: a multicenter retrospective study

Cited by 8 publications

References 36 publications

Risk Factors of Venous Thromboembolism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Risk Factors of Venous Thromboembolism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Venous Thromboembolism Risk in Asian Patients with Inflammatory Bowel Disease: A Population-Based Nationwide Inception Cohort Study

Chinese consensus on diagnosis and treatment in inflammatory bowel disease (2018, Beijing)

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