Incidence and risk factors for colorectal neoplasia in patients with oral squamous cell carcinoma

Kishikawa, Hiroshi; Sato, Keisuke; Yamauchi, Tomohiro; Katakura, Akira; Shibahara, Takeshi; Takano, Nobuo; Nishida, Jiro

doi:10.1111/codi.12717

Cited by 6 publications

(6 citation statements)

References 26 publications

(25 reference statements)

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“… 38 – 40 This may also be related to a recent finding which reported increase of CRNs in oral squamous cell carcinoma patients, which are known to be increased in ESCC patients. 41 However, these associations are not strong, and a causal relationship has not been confirmed. As such, the pathogenic associations need further investigation.…”

Section: Discussionmentioning

confidence: 99%

Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms

et al. 2016

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Background/AimsEsophageal squamous cell carcinoma (ESCC) and colorectal neoplasms (CRNs) share risk factors. We aimed to investigate whether the CRN risk is increased in ESCC patients.MethodsESCC patients who underwent a colonoscopy within 1 year of diagnosis were retrospectively analyzed. Patients were matched 1:3 by age, gender, and body mass index to asymptomatic controls. CRN was defined as the histological confirmation of adenoma or adenocarcinoma. Advanced CRN was defined as any of the following: ≥3 adenomas, high-grade dysplasia, villous features, tumor ≥1 cm, or adenocarcinoma. The risk factors for both CRN and advanced CRN were evaluated by univariate and multivariate analyses.ResultsSixty ESCC patients were compared with 180 controls. The ESCC group had significantly higher numbers of CRNs (odds ratio [OR], 2.311; 95% confidence interval [CI], 1.265 to 4.220; p=0.006) and advanced CRNs (OR, 2.317; 95% CI, 1.185 to 4.530; p=0.013). Significant risk factors for both CRN and advanced CRN by multivariate analysis included ESCC (OR, 2.157, 95% CI, 1.106 to 4.070, p=0.024; and OR, 2.157, 95% CI, 1.045 to 4.454, p=0.038, respectively) and older age (OR, 1.068, 95% CI, 1.032 to 1.106, p<0.001; and OR, 1.065, 95% CI, 1.024 to 1.109, p=0.002, respectively).ConclusionsThe rates of CRN and advanced CRN are significantly increased in ESCC. Colonos-copy should be considered at ESCC diagnosis.

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Section: Discussionmentioning

confidence: 99%

Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms

et al. 2016

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“…After observing statistical data issued by the Ministry of Health and Welfare in Taiwan, we were motivated to study oral cancer. Tobacco smoking, excessive alcohol consumption, and betel nut chewing are the major risk factors for OSCC in Taiwan [ 20 – 22 ]. OSCC constitutes more than 90% of oral cancer malignancies.…”

Section: Discussionmentioning

confidence: 99%

MMP-13 is involved in oral cancer cell metastasis

et al. 2016

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The oral cancer cell line OC3-I5 with a highly invasive ability was selected and derived from an established OSCC line OC3. In this study, we demonstrated that matrix metalloproteinases protein MMP-13 was up-regulated in OC3-I5 than in OC3 cells. We also observed that expression of epithelial–mesenchymal transition (EMT) markers including Twist, p-Src, Snail1, SIP1, JAM-A, and vinculin were increased in OC3-I5 compared to OC3 cells, whereas E-cadherin expression was decreased in the OC3-I5 cells. Using siMMP-13 knockdown techniques, we showed that siMMP-13 not only reduced the invasion and migration, but also the adhesion abilities of oral cancer cells. In support of the role of MMP-13 in metastasis, we used MMP-13 expressing plasmid-transfected 293T cells to enhance MMP-13 expression in the OC3 cells, transplanting the MMP-13 over expressing OC3 cells into nude mice led to enhanced lung metastasis. In summary, our findings show that MMP-13 promotes invasion and metastasis in oral cancer cells, suggesting altered expression of MMP-13 may be utilized to impede the process of metastasis.

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“…The risks of a primary malignancy occurring in sites other than the colon have been reported to be increased in patients with CRNs. 35 – 37 However, the associations between PCa and CRNs have not been extensively investigated. One Swedish study studied the familial association of CRAs with other malignancies and found that families with PCa had an increased incidence of CRAs.…”

Section: Discussionmentioning

confidence: 99%

Prostate cancer patients may have an increased risk of coexisting advanced colorectal neoplasms

Ko¹,

Baeg²,

Bae³

et al. 2016

OTT

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Background/aimsPatients being treated for prostate cancer (PCa) have an increased risk of developing colorectal cancer. However, whether PCa patients are inherently at a higher risk of colorectal neoplasms (CRNs) is unknown. We aimed to investigate the risk of CRNs in PCa patients.Materials and methodsPatients who had been diagnosed with PCa at a tertiary medical center and had colonoscopy within 1 year of the PCa diagnosis were investigated. Patients were propensity-matched 1:2 by age and body mass index to asymptomatic control subjects who had undergone colonoscopy for routine health screening. CRN was defined as histological confirmation of an adenoma or adenocarcinoma component. Advanced CRN was defined as any of the following: 1) histological findings of high-grade dysplasia, 2) inclusion of villous features, 3) tumor ≥1 cm in size, or 4) presence of an adenocarcinoma. Risk factors for CRN and advanced CRN were evaluated by univariate and multivariate analysis.ResultsA total of 191 patients diagnosed with PCa had colonoscopies within 1 year of PCa diagnosis. Of these, 23 patients with a history of previous malignancy and seven with incomplete colonoscopies were excluded, leaving 161 patients in the PCa group. Although presence of PCa was not a significant risk factor for CRN by multivariate analysis, PCa was a significant risk factor for advanced CRN (odds ratio [OR] 3.300; 95% confidence interval [CI] 1.766–6.167; P<0.001). Other significant risk factors for advanced CRN were age (OR 1.050; 95% CI 1.003–1.009; P=0.036) and body mass index (OR 1.205; 95% CI 1.067–1.361; P=0.003), whereas aspirin use (OR 0.414; 95% CI 0.173–0.990; P=0.047) was a preventive factor.ConclusionThe risk of advanced CRN may be significantly increased in patients with PCa. Patients with PCa should have a colonoscopy at the time of PCa diagnosis.

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Incidence and risk factors for colorectal neoplasia in patients with oral squamous cell carcinoma

Cited by 6 publications

References 26 publications

Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms

Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms

MMP-13 is involved in oral cancer cell metastasis

Prostate cancer patients may have an increased risk of coexisting advanced colorectal neoplasms

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