Prostate cancer patients may have an increased risk of coexisting advanced colorectal neoplasms

Ko, Sun-Hye; Baeg, Myong Ki; Bae, Woong Jin; Kim, Pumsoo; Choi, Moon-Gi

doi:10.2147/ott.s110595

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…Furthermore, it is conceivable that men with prostate cancer may be more susceptible to the development of CRC. A lower risk of CRC after prostate cancer was reported in one study [ 42 ] whereas others reported an increased risk of CRC after a diagnosis of prostate cancer [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Risk of colorectal adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer; a nationwide cohort study

Shore

et al. 2023

Cancer Causes Control

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Purpose To assess whether androgens play a role in explaining the sex related differences in the incidence of colorectal cancer (CRC). Methods A nationwide matched cohort study was conducted employing the Prostate Cancer data Base Sweden (PCBaSe) 4.0 during the study period 2006–2016. Prostate cancer (PC) patients receiving androgen deprivation therapy (ADT) were treated as exposed. Prostate cancer-free men from the general population were randomly selected and matched to the index case by birth year and county of residence, forming the unexposed group. All were followed until a diagnosis of CRC, death, emigration, or end of the study period. The risk of CRC among ADT exposed PC patients compared to unexposed cancer-free men was calculated using a flexible parametric survival model and expressed as hazard ratios (HRs) with 95% confidence intervals (CIs). Results There was an increased risk of CRC among ADT exposed PC patients compared to unexposed cancer-free men (HR 1.27 [95% CI 1.15–1.41]), in particular an increased risk of adenocarcinoma of the colon (HR 1.33 [95% CI 1.17–1.51]) and more specifically an increased risk of adenocarcinoma of the distal colon (HR 1.53 [95% CI 1.26–1.85]). Examination of latency effects yielded significantly decreased HRs over time for CRC (p = 0.049 for trend). Conclusions This population-based study found an increased risk of CRC among PC patients exposed to ADT, specifically adenocarcinoma of the distal colon, which indicates an increased association between ADT (PC + ADT) and CRC but not a positive dose-response trend questioning a true causal effect.

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Section: Discussionmentioning

confidence: 99%

Risk of colorectal adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer; a nationwide cohort study

Shore

et al. 2023

Cancer Causes Control

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“…33,34 According to Kim et al, males diagnosed with colorectal cancer have a higher risk for prostate cancer 34 while people with prostate cancer had a higher risk of having advanced abnormal growths in the colon. 33…”

Section: Discussionmentioning

confidence: 99%

“…Evidence suggests that colon and prostate cancer are connected and patients who have had prostate cancer in the past may be more likely to have colorectal cancer. 33,34 According to Kim et al, males diagnosed with colorectal cancer have a higher risk for prostate cancer 34 while people with prostate cancer had a higher risk of having advanced abnormal growths in the colon. 33…”

Section: Skills Acquisition and Specializationmentioning

confidence: 99%

Providers’ Competencies and Management Practices for Traditional Palliative Cancer Care Service Delivery in Kenya

Cheboi,

Ng’ang’a,

Nyamanga

et al. 2023

Health�Serv�Insights

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Background: Many people in developing countries are struggling with chronic diseases yet traditional health services remain under-utilized in the quest for universal health care. Thousands patronize these outlets for care yet little is known about provider’s competence and how these competencies inform palliative care decisions and practices. The study documented traditional health practitioners (THPs) competencies and practices for traditional palliative cancer care service delivery in Kenya. Methods: This study utilized mixed-methods design and was undertaken in major towns across Kenya. A total of 201 Traditional health practitioners were purposely sampled, and interviewed. Five in-depth interviews and 6 focus group discussions were conducted. Quantitative data were analyzed using SPSSv22 while thematic and discourse analysis was carried out for qualitative data. Results: Majority (92.7%) of the THPs provided general traditional health services. Nearly half of the respondents (47.7%, n = 92) stated that they had received their knowledge and abilities through divine gifting, 71 (36.8%) lineage, 61 (31.6%) apprenticeship, and 39 (20.2%) formal study. Palliative care was determined by patient state and followed consultation with caregivers for 165 (85.5%) of respondents. For 160 respondents (83%), management practices involved a mix of patient examination, conventional medical tests, herbal medicine administration, follow-up or referral. Positive feedback consisted of symptom reduction and function recovery. Conclusion: Core competencies identified include: knowledge acquisition and specialization, assessment, diagnosis and disclosure, decision making, treatment, follow-up, and referral. Traditional palliative care providers share common health-related beliefs, practices and abilities that influence how they approach and make decisions regarding the health management of their patients, despite marked ethnic diversity. The shared pathways offer a chance to develop a cogent traditional palliative care service delivery model and health policy framework to promote its integration within the health workforce. The leading unmet requirements are knowledge of intellectual property rights, disclosure frameworks, and ethical regulation principles.

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Screening of chronic radiation proctitis and colorectal cancer using periodic total colonoscopy after external beam radiation therapy for prostate cancer

Nakamura

Soma

Izumi

et al. 2021

Japanese Journal of Clinical Oncology

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Objective To investigate the incidence of colorectal cancer and chronic radiation proctitis after prostate radiotherapy using periodic total colonoscopy screening. Methods From February 2013 to January 2018, 270 patients who underwent external beam radiation therapy for prostate cancer were advised to receive periodic total colonoscopy screening annually. We evaluated the incidence and characteristics of colorectal cancer and chronic radiation proctitis. Results First, second, third, fourth and fifth total colonoscopy were performed in 256 (95%), 151 (56%), 60 (22%), 23 (8.5%) and 7 (2.6%) patients at a median of 14, 31, 42, 54 and 72 months after radiotherapy, respectively. The prevalence proportion of colorectal cancer in the first colonoscopy since radiotherapy was 3.9%. Twelve (4.4%) patients were diagnosed with colorectal cancer, including four invasive cancers, during a follow-up period. Eight of these 12 patients had not experienced rectal bleeding. The median time to diagnosis of colorectal cancer was 21 months. Chronic radiation proctitis was observed in 136 (50%) patients, including 67 (25%) patients with symptomatic bleeding. Conclusions The high detection rate of asymptomatic radiation proctitis suggests the utility of total colonoscopy to screen for early-stage colorectal cancer prior to or following radiotherapy for prostate cancer. Considering the longevity after localized prostate cancer treatment, the awareness of chronic radiation-induced proctitis and the risk of colorectal cancer masked by bleeding is needed in treatment decision -making.

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Prostate cancer patients may have an increased risk of coexisting advanced colorectal neoplasms

Cited by 4 publications

References 42 publications

Risk of colorectal adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer; a nationwide cohort study

Risk of colorectal adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer; a nationwide cohort study

Providers’ Competencies and Management Practices for Traditional Palliative Cancer Care Service Delivery in Kenya

Screening of chronic radiation proctitis and colorectal cancer using periodic total colonoscopy after external beam radiation therapy for prostate cancer

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