Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms

Baeg, Myong Ki; Choi, Moon-Gi; Jung, Yun Hwa; Ko, Sun-Hye; Lim, Chul-Hyun; Kim, Hyung Hun; Kim, Jin Su; Cho, Yu Kyung; Park, Jae Myung; Lee, In Seok; Kim, Sang Woo

doi:10.5009/gnl14381

Cited by 6 publications

(7 citation statements)

References 50 publications

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“…The results of this study were consistent with some other studies that reported the significant association between opium consumption with gastrointestinal tract cancers, especially with upper gastrointestinal cancers such as esophagus and gastric cancer (24,34). Also, some studies reported that the risk of colorectal cancer is high in patients with esophageal cancer (35). The common risk factors for colorectal and esophageal cancer may play an important role in this comorbidity, so the findings of this study show that opium consumption relatively increases the risk of colorectal cancers as much as esophageal cancer in opium users.…”

Section: Discussionsupporting

confidence: 82%

Opium Use and Risk of Lower Gastrointestinal Cancers: Population-Based Case-Control Study in South of Iran

Lankarani¹,

Khosravizadegan²,

Naghibzadeh‐Tahami³

et al. 2017

Int J Cancer Manag

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Background: Colorectal cancers, including colon, rectum and anus, are relatively prevalent in Iran. Use of opium and its derivatives is also considerably prevalent in some areas in Iran. Objectives: The aim of this study was to assess the association between use of opium and its derivatives, and incidence of lower gastrointestinal (LGI) cancers. Methods: This study was a matched case-control study in Shiraz (south of Iran). Cases were the new colorectal cancers from cancer registry center of Shiraz University of Medical Sciences and controls were selected from healthy volunteers of cases' neighbors matched for age and gender (2 controls per 1 case). Data related to consumption of opium and its derivatives, smoking, alcohol use and diet status were collected through a structured questionnaire. The conditional logistic regression models were used to assess all associations. Results: 160 cases and 320 controls participated in the present study with non-response rate less than 9 %. Opium use was associated with increased risk of colorectal cancer (adjusted OR = 4.4; 95% CI: 2.2 -8.8). Also, a dose-response association was observed between cumulative consumption of opium and the colorectal cancer incidence (OR = 3.8; 95% CI: 1.5 -9.1), and (OR = 4.6; 95% CI: 1.7 -12.0) for low and high use, respectively. Also, the significant dose-response association was observed for low (OR = 3.4; 95% CI: 1.2 -9.2) and high (OR = 7.7; 95% CI: 1.5 -38.6) opium use with presence of colon cancer. Conclusions:The results of this study showed that opium use can be an important risk factor for colorectal cancer in Iran.

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Section: Discussionsupporting

confidence: 82%

Opium Use and Risk of Lower Gastrointestinal Cancers: Population-Based Case-Control Study in South of Iran

Lankarani¹,

Khosravizadegan²,

Naghibzadeh‐Tahami³

et al. 2017

Int J Cancer Manag

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“…Other studies showed that colorectal cancers comprise up to 16% of esophageal secondary primary malignancies. 9 However, no previous studies reported isolated EAC metastasis to the colon. There is a reported case of EAC metastasis to the colon, liver, and para-aortic lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Isolated Colonic Metastasis From Esophageal Adenocarcinoma

et al. 2019

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Esophageal cancer is an aggressive and highly lethal malignancy that has a high death-to-incidence ratio approaching 0.90. We present a 60-year-old man with a history of Barrett's esophagus, presented with dysphagia. An upper endoscopy with biopsy confirmed invasive esophageal adenocarcinoma (EAC). Workup, including positron emission tomography scan, showed no evidence of metastasis. A preoperative colonoscopy showed a nodule in the ascending colon that was proven later to be a metastatic lesion from the esophageal primary tumor. Esophageal adenocarcinoma with an isolated colonic metastasis is an extremely rare presentation of esophageal metastasis. These metastatic lesions may not be detected by the positron emission tomography scan.

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“…Superficial ESCC before and after therapy is known to often coincide with primary cancers at other sites, notably the head and neck, stomach, and lung [ 5 , 6 , 10 , 11 ]. The association of CRN has mostly been described with advanced stage ESCC, and even though the proportion of advanced CRN varies widely with reported extremes of 7-66.7%, its frequency is undoubtedly high [ 12 , 13 ]. However, no reports are available concerning CRN in superficial ESCC limited to cases treated with ER, which prompted us to investigate whether similar to the early stage of esophageal cancer the frequency of CRN would be equally high.…”

Section: Discussionmentioning

confidence: 99%

“…Sites of second and third primary cancers developing in these patients include head/neck, stomach, and lung [ 4 - 6 ], while in recent years, colorectal neoplasm (CRN) also frequents coexists [ 10 - 13 ], and thus colonoscopy is recommended in this patient group. In particular, Baeg et al [ 12 ] have argued that since CRN is frequently detected both before and after therapy for ESCC, colonoscopy should be considered when ESCC is first diagnosed. However, these reports focused on esophageal adenocarcinoma [ 10 ], and, even when addressing ESCC, they concentrated on advanced tumors [ 11 , 13 ] with much less attention devoted to the frequency of CRN coexisting with superficial ESCC or the need for colonoscopy in this context.…”

Section: Introductionmentioning

confidence: 99%

Importance of colonoscopy in patients undergoing endoscopic resection for superficial esophageal squamous cell carcinoma

Tominaga

Doyama

Nakanishi

et al. 2016

aog

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BackgroundThe aim of the study was to clarify the frequency of colorectal neoplasm (CRN) complicating superficial esophageal squamous cell carcinoma (ESCC) and the need for colonoscopy.MethodsWe retrospectively reviewed 101 patients who had undergone initial endoscopic resection (ER) for superficial ESCC. Control group participants were age- and sex-matched asymptomatic subjects screened at our hospital over the same period of time. Advanced adenoma was defined as an adenoma ≥10 mm, with villous features, or high-grade dysplasia. Advanced CRN referred to advanced adenoma or cancer. We measured the incidence of advanced CRN in superficial ESCC and controls, and we compared the characteristics of superficial ESCC patients with and without advanced CRN.ResultsIn the superficial ESCC group, advanced CRNs were found in 17 patients (16.8%). A history of smoking alone was found to be a significant risk factor of advanced CRN [odds ratio 6.02 (95% CI 1.30-27.8), P=0.005].ConclusionThe frequency of synchronous advanced CRN is high in superficial ESCC patients subjected to ER. Colonoscopy should be highly considered for most patients who undergo ER for superficial ESCC with a history of smoking, and is recommended even in superficial ESCC patients.

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Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms

Cited by 6 publications

References 50 publications

Opium Use and Risk of Lower Gastrointestinal Cancers: Population-Based Case-Control Study in South of Iran

Opium Use and Risk of Lower Gastrointestinal Cancers: Population-Based Case-Control Study in South of Iran

Isolated Colonic Metastasis From Esophageal Adenocarcinoma

Importance of colonoscopy in patients undergoing endoscopic resection for superficial esophageal squamous cell carcinoma

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