Isolated Colonic Metastasis From Esophageal Adenocarcinoma

Abstract

Esophageal cancer is an aggressive and highly lethal malignancy that has a high death-to-incidence ratio approaching 0.90. We present a 60-year-old man with a history of Barrett's esophagus, presented with dysphagia. An upper endoscopy with biopsy confirmed invasive esophageal adenocarcinoma (EAC). Workup, including positron emission tomography scan, showed no evidence of metastasis. A preoperative colonoscopy showed a nodule in the ascending colon that was proven later to be a metastatic lesion from the esophageal primary tumor. Esophageal adenocarcinoma with an isolated colonic metastasis is an extremely rare presentation of esophageal metastasis. These metastatic lesions may not be detected by the positron emission tomography scan.

An unexpected location for a metastasis from oesophageal squamous carcinoma

“…Additionally, standard staging examinations missed this lesion, hindering their sensitivity in detecting isolated distant metastasis. Although colonoscopy cannot be recommended as part of the workup of oesophageal cancer, in this case allowed the identification of a colonic metastasis, leading to proper a staging and treatment [1,2].…”

c‐Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR‐145‐5p/SPOP/PD‐L1 axis

“…Esophageal adenocarcinoma (EAC) is known as an aggressive malignancy with high mortality 1 . Gastroesophageal reflux disease, obesity, tobacco smoking, and Barrett's esophagus are risk factors for EAC 2 .…”

“…Esophageal adenocarcinoma (EAC) is known as an aggressive malignancy with high mortality. 1 Gastroesophageal reflux disease, obesity, tobacco smoking, and Barrett's esophagus are risk factors for EAC. 2 Among these factors, Barrett's esophagus is deemed to be the precursor lesion of this neoplasm.…”