Inactivity and Inflammation in the Critically Ill Patient

Winkelman, Chris

doi:10.1016/j.ccc.2006.11.002

Cited by 94 publications

(80 citation statements)

References 90 publications

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“…In this study the behavior of this intervention was evaluated for bed ridden patients suffering from immobility, a highly common situation in patients undergoing MV and admitted to ICU. Various effects contribute to muscular weakness, of which bed rest itself stands out, along with an increase in oxidative stress, an increase in inflammatory cytokines, and nutritional status [6].…”

Section: Discussionmentioning

confidence: 99%

“…The role of oxidative stress and inflammatory cytokines in musculature has been studied in laboratories in animal models. It is believed that activity can change the inflammatory cellular message in healthy people [6].…”

Section: *Wilcoxon Testmentioning

confidence: 99%

“…Various oxidant agents can contribute to inflammatory damage to muscles. Superoxide ion (O 2 -), NO, and hydrolyzed radicals (OH-) are examples of RSO [6].…”

Section: Introductionmentioning

confidence: 99%

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Acute Effect of Neuromuscular Electrical Stimulation on Oxidative Stress and Hematological Parameters in Critical Patients

Ribeiro¹,

Amaral²,

Vilaça³

et al. 2017

J immuno Biol

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Aims: To analyze oxidative cellular stress and monitor the evolution of hematological parameters before and after of neuromuscular electrical stimulation (NMES) in critically ill patients. Methods:A controlled and randomized clinical trial, composed of a sample of 19 patients, admitted to the Agamenon Magalhães Hospital intensive care unit. The patients were divided into two groups: NMES group (n=9), patients that underwent only one NMES in the quadriceps muscle for 20 min, and the other, control group (n=10) that did undergo any therapeutic intervention. Results:In relation to the demographic and clinical variables, the groups were homogeneous at the beginning of the study. For the nitric oxide (NO) analysis, we perceived a reduction, when comparing the before and after analyses, in NO in the stimulated cell (p=0.0188) and non-stimulated cell (p=0.0258) in the NMES group. Also in relation to NO, when comparing the two groups, we observed a significant reduction in the NMES group compared to the control one. For the hematological parameters we did not observe any difference when comparing before and after in the two groups studied. Conclusion:We can conclude that the use of NMES causes a reduction in cellular NO levels, showing the beneficial effects in reducing oxidative stress. With relation to complete blood count, we observed that its application was not able to causes any alterations.Keywords: Nitric oxide; Reactive species of oxygen and nitrogen; Physiotherapy in intensive care and physical exercise

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Section: Discussionmentioning

confidence: 99%

Section: *Wilcoxon Testmentioning

confidence: 99%

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Acute Effect of Neuromuscular Electrical Stimulation on Oxidative Stress and Hematological Parameters in Critical Patients

Ribeiro¹,

Amaral²,

Vilaça³

et al. 2017

J immuno Biol

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“…In another study published in 2004 by Kevin & Meyer, hypercalciuria was considered as an important factor in painless hematuria and in a study conducted on children visiting outpatient because of hematuria. Among the 325 patients studied by, 11% of them were hypercalciuric [23].Shane Roye at first did not find result in the investigatin of the cause of hematuria in 5 children, until 14-20 months after the first examination, each of these children eliminated stones or it was seen stone in the graph that this time after urine investigation of calcium all patients had hypercalciuria and after treatment with thiazide hypercalciuria and hematuria resolved in them [24].In this study, the hypercalciuria in the patients on admission to the pediatric intensive care unit was significantly higher than in the control group (44% vs. 10%). This difference was statistically significant (P = 0.0001).…”

Section: Sampling Daysmentioning

confidence: 99%

Effect of Immobilization on Emerging of Hypercalciuria in Patients Admitted to Pediatric Intensive Care Unit

Bilan

Maleki²,

Rahmanian³

et al. 2013

J of clin res gov

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Ab s t r a c tPurpose:Hypercalciuria as a common phenomenon in the normal population is associated with several complications such as urinary tract infections, colic pains and stone formation. In this study, our aim was to investigate association of immobilization and the incidence of hypercalciuria among children.Methods:Forty seven children who were active before the study over 2 years were hospitalized and immobilized in intensive care unit of hospital based on type or severity of illness. Calcium/ creatinine ratio was evaluated, the rate of over 0.21 was considered as hypercalciuria. In 40 healthy children, this value was determined and compared by statistical methods of Paired t-test and independent t -test. P values less than 0.05 was considered as statistically significant. Results:The prevalence of hypercalciuria in immobilized patients was significantly higher than that of the control group after 7 days, which was 37% versus 10% respectively. The rate rose from 37% to 53%, which was not statistically significant .Immobilization alone in the inception of hospitalization (first 48 hours) was associated with impaired calcium excretion in the urine. Urinary tract infection as a complication of hypercalciuria in patients and controls group such as hypercalciuria and uncommon calcium excretion was not normal, but microscopic hematuria was observed in patients with hypercalciuria in about 2.1 items. Conclusion:The hypercalciuria in the immobilized children was significantly more than in the normal children. One of the most common causes of microscopic hematuria in the immobilized patients was hypercalciuria.

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“…Muscle dysfunction is common in mechanically ventilated ICU patients due to physical inactivity, inflammatory processes, and the use of pharmacological agents, e.g., corticosteroids, neuromuscular blocking drugs, and antibiotics [1][2][3][4][5][6][7][8][9][10][11][12][13][14] . Neuromuscular disorders are especially common in these patients, with an average prevalence of 57% 15 .…”

Section: Introductionmentioning

confidence: 99%

Efeito agudo da utilização do cicloergômetro durante atendimento fisioterapêutico em pacientes críticos ventilados mecanicamente

et al. 2016

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RESUMO Pacientes internados em unidades de terapia intensiva (UTI) e ventilados mecanicamente comumente apresentam disfunção muscular devido à inatividade física, à presença de processos inflamatórios e ao uso de agentes farmacológicos. O objetivo deste estudo foi comparar a utilização aguda do cicloergômetro em pacientes críticos ventilados mecanicamente internados em UTI. Trata-se de um ensaio clínico randomizado, no qual foram incluídos 25 pacientes em ventilação mecânica na UTI do Hospital de Clínicas de Porto Alegre. Foram coletadas, pré e pós-intervenção, variáveis hemodinâmicas e respiratórias, bem como foram avaliadas a troca gasosa, por meio da gasometria arterial, os níveis de lactato e proteína C reativa. O protocolo consistiu de diagonais do método de Facilitação Neuromuscular Proprioceptiva de membros superiores e inferiores e técnicas de higiene brônquica, quando necessário. Já no grupo intervenção foi realizado, além da fisioterapia descrita previamente, o cicloergômetro passivo. A análise foi realizada mediante o programa SPSS 18.0. Os dados contínuos foram expressos em média e desvio-padrão, e o nível de significância adotado foi de 5%. Observou-se alteração estatisticamente significativa em relação à pressão de pico (pré: 25,1±5,9; pós: 21,0±2,7cmH2O; p=0,03) no grupo convencional e ao bicarbonato (pré: 23,5±4,3; pós: 20,6±3,0; p=0,002) no grupo intervenção. Concluiu-se que a utilização do cicloergômetro num protocolo de mobilização precoce não altera a mecânica respiratória, nem a hemodinâmica e não resulta em respostas fisiológicas agudas.

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Inactivity and Inflammation in the Critically Ill Patient

Cited by 94 publications

References 90 publications

Acute Effect of Neuromuscular Electrical Stimulation on Oxidative Stress and Hematological Parameters in Critical Patients

Acute Effect of Neuromuscular Electrical Stimulation on Oxidative Stress and Hematological Parameters in Critical Patients

Effect of Immobilization on Emerging of Hypercalciuria in Patients Admitted to Pediatric Intensive Care Unit

Efeito agudo da utilização do cicloergômetro durante atendimento fisioterapêutico em pacientes críticos ventilados mecanicamente

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