IMPORTANCE
Physical rehabilitation in the intensive care unit (ICU) may improve
the outcomes of patients with acute respiratory failure.
OBJECTIVE
To compare standardized rehabilitation therapy (SRT) to usual ICU
care in acute respiratory failure.
DESIGN, SETTING, AND PARTICIPANTS
Single-center, randomized clinical trial at Wake Forest Baptist
Medical Center, North Carolina. Adult patients (mean age, 58 years; women,
55%) admitted to the ICU with acute respiratory failure requiring
mechanical ventilation were randomized to SRT (n=150) or usual care
(n=150) from October 2009 through May 2014 with 6-month
follow-up.
INTERVENTIONS
Patients in the SRT group received daily therapy until hospital
discharge, consisting of passive range of motion, physical therapy, and
progressive resistance exercise. The usual care group received weekday
physical therapy when ordered by the clinical team. For the SRT group, the
median (interquartile range [IQR]) days of delivery of
therapy were 8.0 (5.0–14.0) for passive range of motion, 5.0
(3.0–8.0) for physical therapy, and 3.0 (1.0–5.0) for
progressive resistance exercise. The median days of delivery of physical
therapy for the usual care group was 1.0 (IQR, 0.0–8.0).
MAIN OUTCOMES AND MEASURES
Both groups underwent assessor-blinded testing at ICU and hospital
discharge and at 2, 4, and 6 months. The primary outcome was hospital length
of stay (LOS). Secondary outcomes were ventilator days, ICU days, Short
Physical Performance Battery (SPPB) score, 36-item Short-Form Health Surveys
(SF-36) for physical and mental health and physical function scale score,
Functional Performance Inventory (FPI) score, Mini-Mental State Examination
(MMSE) score, and handgrip and handheld dynamometer strength.
RESULTS
Among 300 randomized patients, the median hospital LOS was 10 days
(IQR, 6 to 17) for the SRT group and 10 days (IQR, 7 to 16) for the usual
care group (median difference, 0 [95% CI, −1.5 to
3], P = .41). There was no difference in
duration of ventilation or ICU care. There was no effect at 6 months for
handgrip (difference, 2.0 kg [95% CI, −1.3 to
5.4], P = .23) and handheld dynamometer
strength (difference, 0.4 lb [95% CI, −2.9 to
3.7], P = .82), SF-36 physical health score
(difference, 3.4 [95% CI, −0.02 to 7.0],
P = .05), SF-36 mental health score
(difference, 2.4 [95% CI, −1.2 to 6.0],
P = .19), or MMSE score (difference, 0.6
[95% CI, −0.2 to 1.4], P
= .17). There were higher scores at 6 months in the SRT group for
the SPPB score (difference, 1.1 [95% CI, 0.04 to 2.1,
P = .04), SF-36 physical function scale score
(difference, 12.2 [95% CI, 3.8 to 20.7],
P = .001), and the FPI score (difference, 0.2
[95% CI, 0.04 to 0.4], P =
.02).
CONCLUSIONS AND RELEVANCE
Among patients hospitalized with acute respiratory failure, SRT
compared with usual care did not decrease hospital LOS.