In vivo transcutaneous penetration of nicotinates and sensitive skin

Berardesca, Enzo; Cespa, M.; Farinelli, Nadia; Rabbiosi, G.; Maibach, Howard I.

doi:10.1111/j.1600-0536.1991.tb01770.x

Cited by 42 publications

(40 citation statements)

References 12 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The application of LA, SLS, capsaicin or cumene failed to enhance differences in erythema responses [20,50,51,53], while the application of octane, acetyl-b-methylcholine chloride, allergen patch testing (European standard and cosmetics), and methyl nicotinate resulted in a stronger erythema response in stingers and in sensitive skin [37,51]. Similar results on methyl nicotinate were found in 1991 [1]. Remarkably, 1 study observed a blanching reaction following methyl nicotinate solely in subjects with sensitive skin [37].…”

Section: Resultssupporting

confidence: 63%

See 1 more Smart Citation

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

Richters

Falcone

Uzunbajakava³

et al. 2014

Skin Pharmacol Physiol

148

View full text Add to dashboard Cite

Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701 articles which we appraised in detail. Impaired skin barrier function and increased vascular reactivity are most often associated with sensitive skin. We identified key reasons causing an ambiguity around the sensitive skin phenomenon. We propose using standardized selection methods of subjects by a multifactorial questionnaire spanning a range of provocations, including those of chemical, mechanical and environmental origin, followed by clinical, histological and top-notch biophysical measurements. This could lead to a breakthrough in the understanding of the sensitive skin phenomenon, fueling advances of biomedical and dermatological science. © 2014 S. Karger AG, Basel

show abstract

Section: Resultssupporting

confidence: 63%

“…Various imprecisely defined terms have been proposed to characterize susceptible skin, emphasizing its heterogeneous presentation, and only few research groups have focused on objective approaches to identify differences in sensitive skin [1,2,3,4,5,6,7,8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

Richters

Falcone

Uzunbajakava³

et al. 2014

Skin Pharmacol Physiol

148

View full text Add to dashboard Cite

show abstract

“…These observations impressively underline how differently the protection barrier and the penetration barrier may behave, an observation which had already been described in a different context [28]. Biophysical statements relating to the skin barrier should therefore be limited to statements concerning singular qualities – even though the behavior is often parallel [5, 29]. …”

Section: Discussionmentioning

confidence: 99%

Opposing Effects of Glycerol on the Protective Function of the Horny Layer against Irritants and on the Penetration of Hexyl Nicotinate

Bettinger

Gloor²,

Peter³

et al. 1998

Dermatology

View full text Add to dashboard Cite

Background: It is known that glycerol in an oil-in-water emulsion has a protective effect against irritating substances. Objective: To answer the question: is the protection effect of glycerol based on a regenerative process? Methods: Upon irritation by either tape stripping or acetone treatment, we applied glycerol to the skin surface under an occlusive dressing to create transepidermal water movement. As a control we used water under the occlusive dressing on the contralateral forearm. After 5 h we compared the barrier function using biological tests. Results: A significant improvement of the protective barrier function was observed in the glycerol-treated areas, as shown by the alkali resistance and by the irritant effect of dimethyl sulfoxide (DMSO) as well as sodium lauryl sulfate. Surprisingly, at the same time penetration of hexyl nicotinate improved on the glycerol-treated areas. A direct physicochemical protection effect on the surface of the skin was ruled out in additional studies using NaOH and DMSO. Conclusions: Under the given conditions glycerol leads to a more rapid reconstitution of the protective skin barrier and initiates a regenerative skin protection. In contrast to that, it is acting as a penetration enhancer.

show abstract

“…When chemical erythema was induced using an MEC of methyl nicotinate, greater reductions in erythema were seen in ibuprofen-treated sites compared with sites treat-vestigators typically administer a standard concentration of methyl nicotinate to all test subjects using concentrations between 36.5 and 100 m M to induce erythema [9][10][11][12][13][14] . However, previous reports indicate that there are individual differences in the extent of erythema response to methyl nicotinate [15] , suggesting that a standard concentration of methyl nicotinate for all test subjects may result in variable responses when evaluating topical anti-infl ammatories. In the current study, we determined that there is a range for the lowest concentration required to induce erythema.…”

Section: Introductionmentioning

confidence: 88%

Establishing a Minimal Erythema Concentration of Methyl Nicotinate for Optimum Evaluation of Anti-Inflammatories

Jumbelic¹,

Liebel²,

Southall³

2006

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Topical administration of chemicals such as methyl nicotinate that induce erythema have been employed to measure the effectiveness of formulations containing anti-inflammatory agents. Prior studies have utilized a single concentration of methyl nicotinate, between 36.5 and 100 mM, for all test subjects in evaluations of topical formulations. However, individuals have different thresholds of response to methyl nicotinate; thus, a single concentration may not be appropriate for all individuals and could result in the apparent lack of anti-inflammatory activity of the formulation being evaluated. In the current study, we evaluated the use of a minimal erythema concentration (MEC) of methyl nicotinate, defined as the lowest concentration that produces a complete and even erythema at the test site, compared with a 36.5-mM concentration of methyl nicotinate. Hydroalcoholic gels containing the nonsteroidal anti-inflammatory drug ibuprofen were compared with placebo. Diffuse reflectance spectroscopy was employed to measure differences in cutaneous inflammatory response between the control (placebo)-treated group and the ibuprofen-treated group. When chemical erythema was induced using an MEC of methyl nicotinate, greater reductions in erythema were seen in ibuprofen-treated sites compared with sites treated with a 36.5-mM concentration of methyl nicotinate. In conclusion, for an accurate assessment method of erythema induced by methyl nicotinate, consideration should be given to determining the extent of response of an erythema-producing agent on an individual basis. An MEC of methyl nicotinate should be determined and employed for each individual to obtain more consistent and reliable efficacy results of anti-inflammatory activity.

show abstract

In vivo transcutaneous penetration of nicotinates and sensitive skin

Cited by 42 publications

References 12 publications

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

Opposing Effects of Glycerol on the Protective Function of the Horny Layer against Irritants and on the Penetration of Hexyl Nicotinate

Establishing a Minimal Erythema Concentration of Methyl Nicotinate for Optimum Evaluation of Anti-Inflammatories

Contact Info

Product

Resources

About