In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile

Bağdaş, Deniz; Etoz, Betul Cam; Gül, Zülfiye; Ziyanok, Sedef; Inan, Sevda; Turacozen, Ozge; Gül, Nihal Y.; Topal, Ayşe; Çinkılıç, Nilüfer; Taş, Sibel; Özyiğit, M. Özgür; Gurun, Mine Sibel

doi:10.1016/j.fct.2015.04.001

Cited by 86 publications

(60 citation statements)

References 68 publications

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“…The present study also included quantification of chlorogenic acid, a natural antioxidant reported for its diabetic wound healing, wound healing, antimicrobial, anti‐inflammatory and antimutagenic, properties . The diabetic wound healing potential of chlorogenic acid was attributed to its enhanced collagen deposition, decreased malondialdehyde/nitric oxide levels, elevated reduced‐glutathione, and restoration of antioxidants such as SOD and CAT . Studies have also reported the potential of chlorogenic acid in inhibiting not only NO (as observed) production but have also inhibited the expression of COX‐2 and iNOS, without any cytotoxicity.…”

Section: Discussionmentioning

confidence: 78%

“…These compounds contribute healing process at different stages by stimulating collagen synthesis and cellular proliferation. The present study also included quantification of chlorogenic acid, a natural antioxidant reported for its diabetic wound healing, wound healing, antimicrobial, anti‐inflammatory and antimutagenic, properties . The diabetic wound healing potential of chlorogenic acid was attributed to its enhanced collagen deposition, decreased malondialdehyde/nitric oxide levels, elevated reduced‐glutathione, and restoration of antioxidants such as SOD and CAT .…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the above altered response may lead to increased incidence of infection, poor wound contraction and decreased wound breaking strength enabling prolonged hospitalization followed by increased mortality rate . In diabetic wounds, the migration of inflammatory cells is delayed at the wounded area, which results in chronic inflammation attributing to a subsequent failure of fibroblast growth and collagen synthesis thus delaying healing processes …”

Section: Introductionmentioning

confidence: 99%

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Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

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Shende

Katare

et al. 2018

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Parmar

Shende

Katare

et al. 2018

Journal of Pharmacy and Pharmacology

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“…Skin wound samples of the second experimental approach were collected for biochemical analyses following the protocols of Bagdas et al [37] and Pereira [38]. Skin wound samples were collected and the animals sacrificed immediately.…”

Section: Methodsmentioning

confidence: 99%

Phytochemical Composition, Antioxidant Activity, and the Effect of the Aqueous Extract of Coffee (Coffea arabica L.) Bean Residual Press Cake on the Skin Wound Healing

Affonso

Voytena

Fanan

et al. 2016

Oxidative Medicine and Cellular Longevity

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The world coffee consumption has been growing for its appreciated taste and its beneficial effects on health. The residual biomass of coffee, originated in the food industry after oil extraction from coffee beans, called coffee beans residual press cake, has attracted interest as a source of compounds with antioxidant activity. This study investigated the chemical composition of aqueous extracts of coffee beans residual press cake (AE), their antioxidant activity, and the effect of topical application on the skin wound healing, in animal model, of hydrogels containing the AE, chlorogenic acid (CGA), allantoin (positive control), and carbopol (negative control). The treatments' performance was compared by measuring the reduction of the wound area, with superior result (p < 0.05) for the green coffee AE (78.20%) with respect to roasted coffee AE (53.71%), allantoin (70.83%), and carbopol (23.56%). CGA hydrogels reduced significantly the wound area size on the inflammatory phase, which may be associated with the well known antioxidant and anti-inflammatory actions of that compound. The topic use of the coffee AE studied improved the skin wound healing and points to an interesting biotechnological application of the coffee bean residual press cake.

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“…Hyperglycemia induces pathological changes in endothelial function resulting to abnormal angiogenesis [33]. The local metabolic environment is impaired by diabetes manifesting macro-and microvascular dysfunction that contributes to delayed wound healing [23].…”

Section: Discussionmentioning

confidence: 99%

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Yusmin

Ahmad

2017

Asian J Pharm Clin Res

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Objective: Nigella sativa and its active constituent thymoquinone (TQ) have been extensively documented for its pharmacological values, but its application in wound healing in particular in a diabetic wound healing model is less documented. Methods:In our study, alloxan-induced diabetic rats were used as a chronic delayed wound model and topical administration of TQ 10% w/v were used to assess the role and function of TQ in wound healing through wound contraction and histological analysis.Results: Although statistically insignificant, we found out that TQ accelerated wound healing in post-wounding day 3 (inflammatory phase), whereas aggressively decelerating wound healing in post-wounding day 7 (proliferation phase). In addition, our histological analyses of wound granulation tissues at post-wounding day 14 substantiate our claim by showing that TQ treatment had delayed wound healing progression of the diabetic rats. Conclusions:Our study shows that TQ accelerates wound healing during the inflammatory phase; however, decelerate rapidly during the proliferation phase. We speculate the acceleration of wound healing during the inflammatory phase was due to its well-documented antioxidant, anti-inflammatory, and antimicrobial properties while its deceleration of wound healing during the proliferation phase was due to its well-documented antiangiogenic effect.

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In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile

Cited by 86 publications

References 68 publications

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Phytochemical Composition, Antioxidant Activity, and the Effect of the Aqueous Extract of Coffee (Coffea arabica L.) Bean Residual Press Cake on the Skin Wound Healing

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

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