Wound healing potential of <i>Solanum xanthocarpum</i> in streptozotocin-induced diabetic rats

Parmar, Komal M.; Shende, Priyanka R; Katare, Nitin T.; Dhobi, Mahaveer; Prasad, Shilpa

doi:10.1111/jphp.12975

Cited by 21 publications

(12 citation statements)

References 47 publications

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“…S. diploconos induced in vitro fibroblast proliferation and accelerated the healing of skin wounds in mice. Similar proliferative and healing actions were previously observed for other Solanum species, such as S. incanum and S. xanthocarpum, which presented healing activities in burn models and in the treatment of diabetic skin ulcers [32,41].…”

Section: Liversupporting

confidence: 79%

Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart.) Bohs

Benvenutti

Nunes

Venturi

et al. 2021

Journal of Immunology Research

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Background. Solanum diploconos (Mart.) Bohs is a native Brazilian plant belonging to the Solanaceae family, popularly known as “tomatinho do mato” and poorly investigated. Herein, we presented for the first time evidence for the anti-inflammatory and wound healing activities of S. diploconos fruit hydroalcoholic extract. Material and Methods. In vitro fMLP-induced chemotaxis, LPS-induced inflammatory mediator levels (cytokines by ELISA and NO release by Griess reaction), and adhesion molecule expression (CD62L, CD49d, and CD18, by flow-cytometry) were assessed in neutrophils treated with different concentrations of the extract. Inflammation resolution was measured by the efferocytosis assay and the healing activity by in vivo and in vitro assays. The air pouch model of carrageenan-induced inflammation in Swiss mice was used to investigate the in vivo anti-inflammatory effects of the extract. Leukocyte influx (by optical microscopy) and cytokine release were quantified in the pouch exudates. Additionally, the acute and subacute toxic and genotoxic effects of the extract were evaluated. Results. In vitro, the extract impaired neutrophil chemotaxis and its ability to produce and/or release cytokines (TNFα, IL-1β, and IL-6) and NO upon LPS stimuli ( p < 0.01 ). LPS-treated neutrophils incubated with the extract presented increased CD62L expression ( p < 0.01 ), indicating a reduced activation. An enhanced efferocytosis of apoptotic neutrophils by macrophages was observed and accompanied by higher IL-10 and decreased TNFα secretion ( p < 0.01 ). In vivo, similar results were noted, including reduction of neutrophil migration, protein exudation, and cytokine release ( p < 0.01 ). Also, the extract increased fibroblast proliferation and promoted skin wound healing ( p < 0.01 ). No signs of toxicity or genotoxicity were observed for the extract. Conclusion. S. diploconos fruit extract is anti-inflammatory by modulating neutrophil migration/activation as well macrophage-dependent efferocytosis and inflammatory mediator release. It also indicates its potential use as a healing agent. Finally, the absence of acute toxic and genotoxic effects reinforces its possible use as medicinal product.

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Section: Liversupporting

confidence: 79%

Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart.) Bohs

Benvenutti

Nunes

Venturi

et al. 2021

Journal of Immunology Research

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“…to prompt diabetes. To avert hypoglycemia caused by the immense insulin discharge, animals were administered 10% glucose solution after 6 h of STZ injection for another 24 h [81,82]. After 72 h of the STZ administration, the blood was withdrawn via animals' tail vein and the animals with a fasting blood glucose level (BGL) higher than 200 mg/dL were considered diabetic and employed in the current study.…”

Section: Induction Of Diabetesmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions

2022

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Green nanotechnology is now accepted as an environmentally friendly and cost-effective advance with various biomedical applications. The cyanobacterium Synechocystis sp. is a unicellular spherical cyanobacterium with photo- and hetero-trophic capabilities. This study investigates the ability of this cyanobacterial species to produce silver nanoparticles (AgNPs) and the wound-healing properties of the produced nanoparticles in diabetic animals. Methods: UV–visible and FT-IR spectroscopy and and electron microscopy techniques investigated AgNPs’ producibility by Synechocystis sp. when supplemented with silver ion source. The produced AgNPs were evaluated for their antimicrobial, anti-oxidative, anti-inflammatory, and diabetic wound healing along with their angiogenesis potential. Results: The cyanobacterium biosynthesized spherical AgNPs with a diameter range of 10 to 35 nm. The produced AgNPs exhibited wound-healing properties verified with increased contraction percentage, tensile strength and hydroxyproline level in incision diabetic wounded animals. AgNPs treatment decreased epithelialization period, amplified the wound closure percentage, and elevated collagen, hydroxyproline and hexosamine contents, which improved angiogenesis factors’ contents (HIF-1α, TGF-β1 and VEGF) in excision wound models. AgNPs intensified catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities, and glutathione (GSH) and nitric oxide content and reduced malondialdehyde (MDA) level. IL-1β, IL-6, TNF-α, and NF-κB (the inflammatory mediators) were decreased with AgNPs’ topical application. Conclusion: Biosynthesized AgNPs via Synechocystis sp. exhibited antimicrobial, anti-oxidative, anti-inflammatory, and angiogenesis promoting effects in diabetic wounded animals.

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“…During ischaemia and hypoxia, the levels of endogenous nitric oxide synthase (NOS) inhibitors increase, and NO synthesis decreases. Treatment with HUCB-MNCs may reduce the level of NOS inhibitors and promote the recovery of NO levels, thereby accelerating wound healing and vasodilation 63 . In this experiment, DD in the experimental group was lower than that in the control group after treatment, which further verified this claim.Collagen is a structural protein of the extracellular matrix that functions to provide strength and integrity to the tissue matrix and plays an extremely important role in wound healing 63 .…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

Cai,

Li,

Gao

et al. 2024

Sci Rep

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Ischaemic bowel disease (ICBD) is a group of intestinal ischaemia syndromes caused by various aetiologies of reduced intestinal blood flow or vascular occlusion. ICBD can present as abdominal pain, bloody stool, and diarrhoea. This disease often occurs in middle-aged and elderly individuals with cardiovascular and cerebrovascular diseases. The incidence of ischaemic bowel disease has been increasing for decades, and it is difficult to diagnose, resulting in rapid disease progression and a high mortality rate. Therefore, fully understanding this disease, improving the diagnosis rate of this disease, and finding appropriate treatment methods are urgently needed to improve the condition and prognosis of patients. Umbilical cord blood stem cells are accessible, have weak immunogenicity, and have various biological functions, such as angiogenesis, inflammation and immune regulation. Many studies have confirmed that cord blood stem cells can relieve ischaemia, and these cells have attracted tremendous amounts of attention in regenerative medicine in recent years. In this paper, we discuss the clinical characteristics of ICBD, analyse the characteristics of human umbilical cord blood mononuclear cells (HUCB-MNCs), and use its to treat ischaemic bowel disease. Additionally, we compare the clinical manifestations and related indicators before and after treatment to evaluate the efficacy and safety of these methods.

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Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Abstract: The potential healing effect in diabetic rats may be attributed to the presence of chlorogenic acid in combination with other phytoconstituents.

Cited by 21 publications

References 47 publications

Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart.) Bohs

Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart.) Bohs

Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

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