In vivo study of antiallergenicity of ethanol extracts from Sargassum tenerrimum, Sargassum cervicorne and Sargassum graminifolium turn

Haider, Samee; Liu, Zhenxing; Lin, Hong; Jamil, Khalid; Wang, Bang Ping

doi:10.1007/s00217-009-1066-4

Cited by 23 publications

(6 citation statements)

References 26 publications

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“…Histological analyses showed improvement in the structure of intestinal epithelial villi, indicating a protective effect of alginate in vivo (81). In a passive as well as active cutaneous anaphylaxis model of ovalbumin and shrimp allergy in Balb/c mice, brown macroalgae extracts from Sargassum tenerrimum, Sargassum cervicorne, and Sargassum graminifolium (turn), when injected peritoneally, suppressed the anaphylactic response (77). Based on these reports, intraperitoneal administration of polysaccharides seems to downregulate pro-inflammatory cytokines, IL-4, IL-5, and IL-13 levels, and suppressing the anaphylactic response through elevated production of IL-12 and IFN-γ.…”

Section: Marine Algaementioning

confidence: 95%

“…Three major groups of marine algae: brown algae, red algae, and green algae, are the main sources of sulfated polysaccharides. Several recent reports have indicated that chemically active metabolites from marine algae can suppress allergen specific antibodies such as IgE, IgG, IgG1 by downregulating CD3, CD4, and CD8 cell surface receptors thereby attenuating the cytokine response (e.g., IL-4, IL-5, and IL-13), in both in vitro and in vivo models of allergy (17,(75)(76)(77)(78). Fucoidan is a sulfated polysaccharide commonly found in different brown algae species.…”

Section: Marine Algaementioning

confidence: 99%

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A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment

et al. 2020

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Section: Marine Algaementioning

confidence: 95%

Section: Marine Algaementioning

confidence: 99%

A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment

et al. 2020

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“…Florotanin potensial dalam menghambat PCA (tergantung dosis) yang dipicu oleh alergen ovalbumin dan udang, aktivitas inhibitornya sebanding dengan disodiumcromoglycate (obat antialergi). Florotanin juga mampu menghambat ACA (tergantung dosis) yang dipicu oleh alergen dari ovalbumin dan udang (Haider et al, 2009).…”

Section: Jenis-jenis Senyawa Bioaktif Pada Sargassum Sp Florotaninunclassified

“…Potensi penghambatan enzim cyclooxygenase 1 dan 2 oleh fukoidan lebih baik dibandingkan aspirin (obat non-steroidal antiinflamasi) dan alginat, sehingga potensial sebagai antiinflamasi (Dewi, 2016). (menekan PCA dan ACA tikus betina) (Haider et al, 2009;Li et al, 2017;Ye et al, 2009)…”

Section: Fukoidanunclassified

Senyawa-Senyawa Bioaktif Pada Rumput Laut Cokelat Sargassum Sp. : Ulasan Ilmiah

Rohim¹,

Yunianta²,

Estiasih³

2019

JTP

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Genus Sargassum termasuk kelas rumput laut cokelat (Phaeophyceae) yang terdiri dari sekitar 400 spesies, dan banyak ditemukan di perairan Indonesia. Sargassum sp. kaya dengan berbagai jenis senyawa bioaktif, yang penting untuk pencegahan maupun terapi berbagai penyakit. Ulasan ilmiah ini dilakukan untuk mengulas jenis-jenis senyawa bioaktif, senyawa bioaktif dominan, dan aktivitas biologisnya dalam genus Sargassum, berdasarkan penelitianpenelitian ilmiah yang telah dipublikasikan. Dari ulasan ilmiah ini dapat diketahui bahwa senyawa-senyawa bioaktif dalam Sargassum sp. meliputi florotanin, terpenoid, chromene, derivat tetraprenyltoluquinol, fukosantin, fukoidan, alginat, asam-asam fenolat, katekin, kuersetin, fukosterol, stigmasterol, β-sitosterol, feofitin A, dan sulfoquinovosyldiacylglycerol. Florotanin, fukosantin, fukoidan, alginat, fukosterol, meroditerpenoid dan gentisic acid adalah senyawa bioaktif dominan dalam Sargassum sp. Meroditerpenoid merupakan senyawa bioaktif khas dalam Sargassum sp., yang tidak diproduksi oleh genus rumput laut lainnya. Aktivitas biologis dari senyawa-senyawa bioaktif Sargassum sp. yaitu antioksidan, antikanker, antitumor, antiinflamasi, antihipertensi, antiobesitas, antidiabetes, antibakteri, antifungi, antivirus, antialergi (ovalbumin dan udang), hipokolesterolemia, neuroprotektif, pencerah kulit dan proteksi ROS intraseluler. Dengan demikian, senyawa-senyawa bioaktif dalam Sargassum sp. potensial untuk mendorong kesehatan

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“…Sargassum graminifolium , a brown seaweed extensively distributed along the coasts of the South China Sea and the East China Sea, is commonly consumed as seafood and has antiallergic effects and some other medical properties [18]. Therefore, it is important to evaluate the polysaccharide bioactivity of S. graminifolium to fully utilize this rich resource.…”

Section: Introductionmentioning

confidence: 99%

The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage

Zhang

Kong

et al. 2013

Marine Drugs

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The aim of the present study is to evaluate the protective effect of polysaccharide from the Brown Seaweed Sargassum graminifolium (SGP) on ethylene glycol-induced kidney damage and the mechanism of SGP-mediated protection. Mitochondrial lipid peroxidation, mitochondrial swelling, the activity of succinate dehydrogenase (SDH), ATPases and mitochondrial antioxidant enzymes was observed in hyperoxaluric rats. Administration of SGP (25, 100 and 400 mg·kg−1, intragastrically) increased the activities of antioxidant enzymes, SDH and Na+/K+-ATPases, Ca2+-ATPases, Mg2+-ATPases, also decreased mitochondrial lipid peroxidation and mitochondrial swelling. SGP exhibited a protective effect by improving antioxidant enzymes and restoring mitochondrial dysfunction in the kidney of hyperoxaluric rats. It may be used as a promising therapeutic agent to provide superior renal protection.

show abstract

In vivo study of antiallergenicity of ethanol extracts from Sargassum tenerrimum, Sargassum cervicorne and Sargassum graminifolium turn

Cited by 23 publications

References 26 publications

A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment

A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment

Senyawa-Senyawa Bioaktif Pada Rumput Laut Cokelat Sargassum Sp. : Ulasan Ilmiah

The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage

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