In vivo Remineralization of Artificial Enamel Lesions by a Fluoride Dentifrice or Mouthrinse

Corpron, Richard E.; More, Frederick G.; Clark, James W.; Korytnicki, Daniel; Kowalski, Charles J.

doi:10.1159/000260919

Cited by 39 publications

(21 citation statements)

References 15 publications

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“…In addition, by selec ting partial denture wearers, previous workers may have chosen individuals with an increased tendency to dental car ies who may not be representative of the general population. In the present study, however, the DMFS scores showed that, apart from subject 3, participants exhibited disease prevalances not atypical of their age range (mean = 32 years), this being younger than for those reported previ ously [Stookcy ct al.. 1985;Corpron et al, 1986;Schafer 1989]. Hence, this model system would seem to mimic the natural situation more closely.…”

Section: Discussioncontrasting

confidence: 56%

Demonstration of a Fluoride Dose Response with an In situ Single-Section Dental Caries Model

Damato¹,

Stephen²

1994

Caries Res

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The in situ dental caries model developed in Glasgow was evaluated by determining whether it could demonstrate a fluoride dose response in a crossover study using 0, 250, and 1,000 ppm F from sodium fluoride dentifrices. In situ appliances, each carrying four enamel sections with multiple artifícal carious lesions, were worn by 12 dentate subjects for three 5-week experimental runs, during which they brushed twice daily with a test paste. Mineral changes in the lesions were measured by analyzing microradiographs, using an image analysis system, after 0, 2, 4, and 5 weeks and the rate of change calculated. Two-way analysis of variance showed no significant intersubject effects (for any of the parameters), but demonstrated strong evidence of a linear fluoride dose effect: total mineral loss (▵z) p = 0.0596; lesion body p = 0.0423; surface zone p = 0.0081. However, the exclusion of the data from 1 low-caries (DMFS = 1), high-calculus-forming subject produced even stronger evidence as to the efficacy of this model (▵z p = 0.0226; lesion body p = 0.0164; surface zone p = 0.0081). Hence, these results suggest this model is useful for studying fluoride products according to guidelines of American Dental Association.

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Section: Discussioncontrasting

confidence: 56%

Demonstration of a Fluoride Dose Response with an In situ Single-Section Dental Caries Model

Damato¹,

Stephen²

1994

Caries Res

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“…The suitability of in situ models for measuring the remineralization potential of toothpastes, mouthrinses, and gels has been demonstrated in a series of studies [Gelhard and Arends, 1984;Mellberg et al, 1985Mellberg et al, , 1986de Kloet et al, 1986;Goorhuis and Purdell-Lewis, 1986;Corpron et al, 1986]. However, the various experimental modifications in these studies have, not unexpectedly, indicated differences in the ability of the models to detect changes in enamel min eralization.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Anticaries Benefit of Fluoride Toothpastes Using an Enamel Insert Model

Schäfer

1989

Caries Res

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The remineralization potential of fluoride toothpastes was studied using an in situ enamel insert model. Matched blocks of artificially demineralized human enamel were attached to partial dentures of 16 adult volunteers who brushed their teeth with either a toothpaste containing 1,500 ppm F or one containing 2,500 ppm F for a period of 6 weeks in a balanced, randomized crossover experiment. Computerized image analysis of microradiographs was used to measure the mineral density distribution in the enamel before and after in situ treatment. Both toothpastes demonstrated remineralization of artificial carious lesions. Significantly more remineralization was observed in enamel samples treated with the toothpaste containing 2,500 ppm F compared to that containing 1500 ppm F. This result is consistent with the outcome of a recent caries clinical trial testing the same toothpastes and finding enhanced anticaries efficacy from the higher fluoride level.

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“…These findings are in general agreement with previous studies of fluoride effects, and are the result of fluoride-enhanced remineralization and inhibition by fluo ride of acid attack in the lesion areas. In earlier studies, dentifrices and/or solu tions containing sodium fluoride have been found effective for enhancing the remineralization of enamel both in vitro and in vivo [Corpron et al, 1986;Featherstone et al, 1986a, b;Mellberg and Mallon, 1984;White, 1987] although the abso lute magnitude of efficacy has varied. The NaF has appeared to be most effective in the remineralization and fluoride enrich ment of early carious lesions and subse quent enhancement of the resistivity of the remineralized enamel to acid damage.…”

Section: Discussionmentioning

confidence: 99%

A Longitudinal Microhardness Analysis of Fluoride Dentifrice Effects on Lesion Progression in vitro

1987

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The longitudinal microhardness technique has been used to determine the effect of a sodium fluoride dentifrice on the progression of artificial carious lesions in a pH cycling model in vitro. The NaF dentifrice was found to be extremely effective in reducing the progression of caries in enamel, limiting both the depth of acid damage and the degree of mineral loss measured at discrete intervals within specimens. Lesion progression areas, estimated using Simpson’s rule to integrate hardness data, indicated that the NaF dentifrice effected a 73 and 82% overall reduction in lesion advancement, relative to placebo and untreated controls. This area analysis appeared to represent a useful means for simplifying comparisons of treatment effects in remineralization studies using cross-sectional microhardness as the measurement tool. In terms of comparative accuracy to microradiography, analysis of published data indicated that the longitudinal microhardness technique, while limited in some respects, can provide useful estimates of remineralization/lesion-progression areas.

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In vivo Remineralization of Artificial Enamel Lesions by a Fluoride Dentifrice or Mouthrinse

Cited by 39 publications

References 15 publications

Demonstration of a Fluoride Dose Response with an In situ Single-Section Dental Caries Model

Demonstration of a Fluoride Dose Response with an In situ Single-Section Dental Caries Model

Evaluation of the Anticaries Benefit of Fluoride Toothpastes Using an Enamel Insert Model

A Longitudinal Microhardness Analysis of Fluoride Dentifrice Effects on Lesion Progression in vitro

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