Dental calculus, both supra- and subgingival occurs in the majority of adults worldwide. Dental calculus is calcified dental plaque, composed primarily of calcium phosphate mineral salts deposited between and within remnants of formerly viable microorganisms. A viable dental plaque covers mineralized calculus deposits. Levels of calculus and location of formation are population specific and are affected by oral hygiene habits, access to professional care, diet, age, ethnic origin, time since last dental cleaning, systemic disease and the use of prescription medications. In populations that practice regular oral hygiene and with access to regular professional care, supragingival dental calculus formation is restricted to tooth surfaces adjacent to the salivary ducts. Levels of supragingival calculus in these populations is minor and the calculus has little if any impact on oral-health. Subgingival calculus formation in these populations occurs coincident with periodontal disease (although the calculus itself appears to have little impact on attachment loss), the latter being correlated with dental plaque. In populations that do not practice regular hygiene and that do not have access to professional care, supragingival calculus occurs throughout the dentition and the extent of calculus formation can be extreme. In these populations, supragingival calculus is associated with the promotion of gingival recession. Subgingival calculus, in "low hygiene" populations, is extensive and is directly correlated with enhanced periodontal attachment loss. Despite extensive research, a complete understanding of the etiologic significance of subgingival calculus to periodontal disease remains elusive, due to inability to clearly differentiate effects of calculus versus "plaque on calculus". As a result, we are not entirely sure whether subgingival calculus is the cause or result of periodontal inflammation. Research suggests that subgingival calculus, at a minimum, may expand the radius of plaque induced periodontal injury. Removal of subgingival plaque and calculus remains the cornerstone of periodontal therapy. Calculus formation is the result of petrification of dental plaque biofilm, with mineral ions provided by bathing saliva or crevicular fluids. Supragingival calculus formation can be controlled by chemical mineralization inhibitors, applied in toothpastes or mouthrinses. These agents act to delay plaque calcification, keeping deposits in an amorphous non-hardened state to facilitate removal with regular hygiene. Clinical efficacy for these agents is typically assessed as the reduction in tartar area coverage on the teeth between dental cleaning. Research shows that topically applied mineralization inhibitors can also influence adhesion and hardness of calculus deposits on the tooth surface, facilitating removal. Future research in calculus may include the development of improved supragingival tartar control formulations, the development of treatments for the prevention of subgingival calculus formation, the development ...

Five discrete accretionary events assembled fragments of continental and oceanic crust into a coherent Superior craton by 2.60 Ga. They exhibit similar sequences of events at ~10 million year intervals: cessation of arc magmatism, early deformation, synorogenic sedimentation, sanukitoid magmatism, bulk shortening, regional metamorphism, late transpression, orogenic gold localization, emplacement of crust-derived granites, and postorogenic cooling. The Northern Superior superterrane recorded 3.7–2.75 Ga events prior to 2.72 Ga collision with the 3.0 Ga North Caribou superterrane. Following 2.98 Ga rifting, the Uchi margin of the North Caribou superterrane evolved in an upper plate setting before 2.72–2.70 Ga collision of the <3.4 Ga Winnipeg River terrane, which trapped synorogenic English River turbidites in the collision zone. The Winnipeg River terrane was reworked in 2.75–2.68 Ga magmatic and tectonic events, including the central Superior orogeny (2.71–2.70 Ga) that marks accretion of the juvenile western Wabigoon terrane. In the south, the Wawa–Abitibi terrane evolved in a mainly oceanic setting until Shebandowanian collision with the composite Superior superterrane at 2.695 Ga. Synorogenic Quetico turbidites were trapped in the collision zone. The final accretionary event involved addition of the Minnesota River Valley terrane (MRVT) from the south, and deposition and metamorphism of synorogenic turbidites of the Pontiac terrane during the ~2.68 Ga Minnesotan orogeny. Seismic reflection and refraction images indicate north-dipping structures, interpreted as a stack of discrete 10–15 km thick terranes. A slab of high-velocity material, possibly representing subcreted oceanic lithosphere, as well as Moho offsets, support a model of progressive accretion through plate-tectonic-like processes.

A series of chlorinated bisindole pyrroles, lynamicins A-E (1-5), was discovered from a novel marine actinomycete, NPS12745, which was isolated from a marine sediment collected off the coast of San Diego, California. Close to full length 16S rRNA sequence analysis indicated that NPS12745 is a novel strain of a recently described marine actinomycete with the proposed genus name Marinispora. The antimicrobial spectrum of these compounds was evaluated against a panel of 11 pathogens, which demonstrated that these substances possess broad-spectrum activity against both Gram-positive and Gram-negative organisms. Significantly, compounds 1-5 were active against drug-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.

Due to high metal prices and increased difficulties in finding shallower deposits, the exploration for and exploitation of mineral resources is expected to move to greater depths. Consequently, seismic methods will become a more important tool to help unravel structures hosting mineral deposits at great depth for mine planning and exploration. These methods also can be used with varying degrees of success to directly target mineral deposits at depth. We review important contributions that have been made in developing these techniques for the mining industry with focus on four main regions: Australia, Europe, Canada, and South Africa. A wide range of case studies are covered, including some that are published in the special issue accompanying this article, from surface to borehole seismic methods, as well as petrophysical data and seismic modeling of mineral deposits. At present, high-resolution 2D surveys mostly are performed in mining areas, but there is a general increasing trend in the use of 3D seismic methods, especially in mature mining camps.

No abstract

Synthetic polymer gels have been examined as decalcifying media for the preparation of artificial carious lesions in tooth enamel. Enamel specimens were demineralized in lactic acid/calcium phosphate buffers containing 0.1–0.5% (w/w) polyacrylic acid (Carbopol C907, MW = 450,000 daltons) to act as a surface-protective agent. The rate, histology and physical characteristics of lesions were characterized by surface microhardness, polarized light, and microradiographic analyses. Following demineralization, selected lesions were remineralized in solutions supersaturated with respect to fluoroapatite. The results show that polyacrylic acid is extremely useful and effective as a surface-protective agent for artificial carious lesion preparation. The histology of lesions formed in C907 gels can be carefully controlled by adjusting the undersaturation of the demineralization medium with respect to tooth mineral salts. Lesions formed in C907 gels are extremely reactive towards remineralization and the rate and histology of mineral repair are not noticeably influenced by the resin content in solution. The use of synthetic polymer gels is recommended for the systematic reproducible preparation of artificial carious lesions in dental enamel.

The longitudinal microhardness technique has been used to determine the effect of a sodium fluoride dentifrice on the progression of artificial carious lesions in a pH cycling model in vitro. The NaF dentifrice was found to be extremely effective in reducing the progression of caries in enamel, limiting both the depth of acid damage and the degree of mineral loss measured at discrete intervals within specimens. Lesion progression areas, estimated using Simpson’s rule to integrate hardness data, indicated that the NaF dentifrice effected a 73 and 82% overall reduction in lesion advancement, relative to placebo and untreated controls. This area analysis appeared to represent a useful means for simplifying comparisons of treatment effects in remineralization studies using cross-sectional microhardness as the measurement tool. In terms of comparative accuracy to microradiography, analysis of published data indicated that the longitudinal microhardness technique, while limited in some respects, can provide useful estimates of remineralization/lesion-progression areas.

A schematic crustal cross-section is presented for the southwestern Grenville Province based on reprocessed Lithoprobe near-vertical incidence seismic reflection data and compiled seismic refraction - wide-angle velocity models interpreted with geological constraints. The schematic crustal architecture of the southwest Grenville Province from southeast to northwest comprises allochthonous crustal elements (Frontenac-Adirondack Belt and Composite Arc Belt) that were assembled prior to ca. 1160 Ma, and then deformed and transported northwest over reworked rocks of pre-Grenvillian Laurentia and the Laurentian margin primarily between 1120 and 980 Ma. Reworked pre-Grenvillian Laurentia and Laurentian margin rocks are interpreted to extend at least 350 km southeast of the Grenville Front beneath all of the Composite Arc Belt. Three major structural boundary zones (the Grenville Front and adjacent Grenville Front Tectonic Zone, the Central Metasedimentary Belt boundary thrust zone, and the Elzevir-Frontenac boundary zone) have been identified across the region of the cross-section based on their prominent geophysical signatures comprising broad zones of southeast-dipping reflections and shallowing of mid-crustal velocity contours by 12-15 km. The structural boundary zones accommodated southeast over northwest crustal stacking at successively earlier times during orogeny (ca. 1010-980 Ma, 1080-1060 Ma, and 1170-1160 Ma, respectively). These shear zones root within an interpreted gently southeast-dipping regional décollement at a depth of 25-30 km corresponding to the top of a high-velocity lower crustal layer.