In vivo radioprotection by α-TMG: preliminary studies

Normal Tissue Protectors Against Radiation Injury

“…Injection of 600 mg/kg b.w. of TMG 5 min after irradiation provided the maximum protection 46 , giving a DMF of ~1.1 for mouse survival 47 , which is similar to that reported for vitamin E 41 . DMFs of ~1.5 and ~2 were obtained for reducing chromosomal aberrations and micronuclei, respectively, in mouse bone marrow 47 .…”

“…The vitamins C and E have been reported to protect mouse bone marrow chromosomes even when administered shortly after irradiation found that vitamin E was effective post-irradiation administration scenario. a-TMG gave maximum protection against whole-body irradiation when administered within a short time after irradiation 46,47 . The possibility of developing these into drugs for human application in nuclear emergencies is worth considering.…”

Prophylactic effects of magnesium and vitamin E in rat spinal cord radiation damage: evaluation based on lipid peroxidation levels

“…Further, Konopacka et al (1998) found that vitamin E had a radioprotective effect against DNA damage due to gamma irradiation in bone marrow polychromatic erythrocytes and exfoliated bladder cells of rats. Other work has revealed that a water-soluble derivative of vitamin E, alpha-TMG, is very effective at preventing radiation-induced aberrant metaphase in whole-body-irradiated adult mice (Satyamitra et al, 2001).…”

Role of Radioprotectors in the Inhibition of DNA Damage and Modulation of DNA Repair After Exposure to Gamma-Radiation

“…Radiation induced formation of micronucleated polychromatic and normochromatic erythrocytes in mouse bone marrow cells was inhibited by a single injection of TMG (0.6 g/kg body weight) i.p. after the radiation exposure with a dose reduction factor of 0.5 (Satyamitra et al 2001). Our in vitro studies, either with humans or mice, peripheral blood leucocytes showed that the presence of TMG (0.5 mM) in post-irradiation incubation medium did not enhance the repair of DNA strand breaks (Salvi et al 2007).…”