Normal Tissue Protectors Against Radiation Injury

Devi, P. Uma; Agrawala, Paban K.

doi:10.14429/dsj.61.829

Cited by 8 publications

(4 citation statements)

References 69 publications

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“…Radioprotectors function on the premise that some chemicals when given before irradiation protect the vital biomolecules from radiation-induced lesions, either by preventing the initial damage to the vital tissues or by restituting the original structure by repair, or both. [ 20 , 26 , 27 ] The modern approach of understanding the mechanism of the antiulcer effect of protective compounds such as RtH should therefore be directed towards exploring its possible role in preventing oxidative damage and apoptosis as well as on the promotion of healing process by cell proliferation. [ 26 ] A radioprotective agent should protect normal tissues that are considered sensitive, should reduce acute or late toxicities in these tissues and finally should be responsible for a significant improvement in the quality of life, not only symptomatically but also on the functional level (i.e.…”

Section: Resultsmentioning

confidence: 99%

Radioprotective effect ofRapana thomasianahemocyanin in gamma induced acute radiation syndrome

Kindekov¹,

Mileva²,

Krastev³

et al. 2014

Biotechnology & Biotechnological Equipment

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The radioprotective effect of Rapana thomasiana hemocyanin (RtH) against radiation-induced injuries (stomach ulcers, survival time and endogenous haemopoiesis) and post-radiation recovery was investigated in male albino mice (C3H strain). Radiation course was in a dose of 7.5 Gy (LD 100/30 – dose that kills 100% of the mice at 30 days) from 137Cs with a dose of 2.05 Gy/min. Radiation injuries were manifested by inducing а hematopoietic form of acute radiation syndrome. RtH was administered intraperitoneally in a single dose of 50, 100, 150 and 200 mg/kg body weight (b. w.) once a day for five consecutive days before irradiation. The results obtained showed that radiation exposure led to (1) 100% mortality rate, (2) ulceration in the stomach mucosa and (3) decrease formation of spleen colonies as a marker of endogenous haemopoiesis. Administration of RtH at a dose of 200 mg/kg provided better protection against radiation-induced stomach ulceration, mitigated the lethal effects of radiation exposure and recovered endogenous haemopoiesis versus irradiated but not supplemented mice. It could be expected that RtH will find a use in mitigating radiation induced injury and enhanced radiorecovery.

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Section: Resultsmentioning

confidence: 99%

Radioprotective effect ofRapana thomasianahemocyanin in gamma induced acute radiation syndrome

Kindekov¹,

Mileva²,

Krastev³

et al. 2014

Biotechnology & Biotechnological Equipment

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“…Most radiation-induced side effects are due to the free radicals produced by IR in cells [7]. Radioprotectors (or radioprotective agents) have been proposed for preventing or reducing these side effects.…”

Section: Introductionmentioning

confidence: 99%

Radioprotective Effect of Hesperidin: A Systematic Review

et al. 2019

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Background and objectives: Ionizing radiation (IR) has been of immense benefit to man, especially for medical purposes (diagnostic imaging and radiotherapy). However, the risks of toxicity in healthy normal cells, leading to cellular damage as well as early and late side effects, have been major drawbacks. The aim of this study was to evaluate the radioprotective effect of hesperidin against IR-induced damage. Materials and Methods: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were applied in reporting this study. A search was conducted using the electronic databases PubMed, Scopus, Embase, Google Scholar, and www.ClinicalTrials.gov for information about completed or ongoing clinical trials. Results: From our search results, 24 studies involving rats, mice, and cultured human and animal cells were included. An experimental case—control design was used in all studies. The studies showed that the administration of hesperidin reduced oxidative stress and inflammation in all investigated tissues. Furthermore, it increased 30-day and 60-day survival rates and protected against DNA damage. The best radioprotection was obtained when hesperidin was administered before irradiation. Conclusions: The results of the included studies support the antioxidant, anti-inflammatory, and antiapoptotic abilities of hesperidin as a potential radioprotective agent against IR-induced damage. We recommend future clinical trials for more insights.

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“…A synergistic effect of dietary antioxidants capable of protecting normal tissue during radiation therapy to a greater extent than the individual components has been observed [79–81]. SH-compounds have been found to be toxic in humans, while compounds increasing glutathione, such as α-lipoic acid and N -acetylcysteine, which are less toxic to humans, are now commonly used to protect against radiation damage [60,77,81–85]. …”

Section: Protection Strategy In Humans and The Search For Biologicmentioning

confidence: 99%

Preventive or Potential Therapeutic Value of Nutraceuticals against Ionizing Radiation-Induced Oxidative Stress in Exposed Subjects and Frequent Fliers

Giardi¹,

Touloupakis

Bertolotto

et al. 2013

IJMS

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Humans are constantly exposed to ionizing radiation deriving from outer space sources or activities related to medical care. Absorption of ionizing radiation doses over a prolonged period of time can result in oxidative damage and cellular dysfunction inducing several diseases, especially in ageing subjects. In this report, we analyze the effects of ionizing radiation, particularly at low doses, in relation to a variety of human pathologies, including cancer, and cardiovascular and retinal diseases. We discuss scientific data in support of protection strategies by safe antioxidant formulations that can provide preventive or potential therapeutic value in response to long-term diseases that may develop following exposure.

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Normal Tissue Protectors Against Radiation Injury

Cited by 8 publications

References 69 publications

Radioprotective effect ofRapana thomasianahemocyanin in gamma induced acute radiation syndrome

Radioprotective effect ofRapana thomasianahemocyanin in gamma induced acute radiation syndrome

Radioprotective Effect of Hesperidin: A Systematic Review

Preventive or Potential Therapeutic Value of Nutraceuticals against Ionizing Radiation-Induced Oxidative Stress in Exposed Subjects and Frequent Fliers

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