Prophylactic effects of magnesium and vitamin E in rat spinal cord radiation damage: evaluation based on lipid peroxidation levels

Peker, Selçuk; Abacıoğlu, Ufuk; Sun, Ibrahim; Konya, Deniz; Yüksel, Meral; Pamir, Necmettin

doi:10.1016/j.lfs.2004.05.003

Cited by 19 publications

(15 citation statements)

References 37 publications

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“…Moreover, MgSO 4 has been shown to possess potent anti-oxidation capacity, as preeclamptic women treated with MgSO 4 were found to have less lipid peroxidation [8]. This concept is further supported by previous data that hypoxia-induced brain damage in fetal guinea pig [9] and radiation-induced oxidative stress in rat spinal cord [10] could both be attenuated by MgSO 4 .…”

Section: Introductionsupporting

confidence: 65%

Magnesium Sulfate Mitigates Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

Kao¹,

Jan²,

Tsai³

et al. 2011

Journal of Surgical Research

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Section: Introductionsupporting

confidence: 65%

Magnesium Sulfate Mitigates Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

Kao¹,

Jan²,

Tsai³

et al. 2011

Journal of Surgical Research

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“…Mg 2+ has also been shown to inhibit the lipid peroxidation and to prevent the depletion of glutathione levels. These conditions suppress the generation of free radicals (Dickens et al, 1992; Peker et al, 2004), suggesting that the antioxidant property of Mg 2+ may represent another mechanism by which it inhibits the mPT.…”

Section: Discussionmentioning

confidence: 99%

Inhibitors of the mitochondrial permeability transition reduce ammonia‐induced cell swelling in cultured astrocytes

Reddy

Rao

Norenberg

2009

J of Neuroscience Research

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Ammonia is the principal neurotoxin implicated in the pathogenesis of hepatic encephalopathy, and astrocytes are the neural cells predominantly affected in this condition. Astrocyte swelling (cytotoxic edema) represents a critical component of the brain edema in acute form of hepatic encephalopathy (acute liver failure, ALF). Although mechanisms of astrocyte swelling by ammonia are not completely understood, cultured astrocytes exposed to pathophysiological levels of ammonia develop the mitochondrial permeability transition (mPT), a process that was shown to result in astrocyte swelling. Cyclosporin A (CsA), a traditional inhibitor of the mPT, was previously shown to completely block ammonia-induced astrocyte swelling in culture. However, the efficacy of CsA to protect cytotoxic brain edema in ALF is problematic because it poorly crosses the blood-brain barrier, which is relatively intact in ALF. We therefore examined the effect of agents that block the mPT but are also known to cross the blood-brain barrier, including pyruvate, magnesium, minocycline, and trifluoperazine on the ammonia-induced mPT, as well as cell swelling. Cultured astrocytes exposed to ammonia for 24 hr displayed the mPT as demonstrated by a CsA-sensitive dissipation of the mitochondrial inner membrane potential. Pyruvate, minocycline, magnesium, and trifluoperazine significantly blocked the ammonia-induced mPT. Ammonia resulted in a significant increase in cell volume, which was blocked by the above-mentioned agents to a variable degree. A regression analysis indicated a high correlation between the effectiveness of reducing the mPT and cell swelling. Our data suggest that all these agents have therapeutic potential in mitigating brain edema in ALF.

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“…Mg injections were able to decrease malondialdéhyde (MDA) levels in diabetic rats [16]. Mg supplementation is also capable of preventing lipid peroxidation whether in vitro [63] or in vivo [64] and is known to inhibit excessive production of oxygen free radicals [17]. In the current study, magnesium injections were also able to decrease the activities of antioxidant enzymes to normal levels.…”

Section: Discussionmentioning

confidence: 57%

Effects of MgCl2 supplementation on blood parameters and kidney injury of rats exposed to CCl4

et al. 2016

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The purpose of this study was to evaluate the beneficial effects of magnesium (Mg) supplementation upon carbon tetrachloride (CCl4) toxicity. Our study was carried out on 24 Wistar male rats divided into 4 batches. During a 6 week period, one group served as a control, two groups received Mg (after 4 weeks one of these groups was then treated with CCl4), and a final group was treated with CCl4 only. Under our experimental conditions, CCl4 poisoning resulted in oxidative stress indicated by a significant increase in lipid peroxidation level in renal tissues. The blood levels of creatinine and urea increased while the blood level of uric acid and proteins decreased. CCl4 also induced an increase in superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity in kidneys, in the number of red blood cells (RBC), and in hemoglobin content (Hb) and mean cell hemoglobin concentration (MCHC). However, white blood cell count (WBC), platelet count (Pl) and catalase activity (CAT) all decreased significantly. Treatment with Mg was found to alleviate most of CCl4-induced damage by decreasing lipid peroxidation and by correcting changed hematological parameters, and catalase, glutathione peroxidase and superoxide-dismutase activities. The results provide strong evidence that Mg supplementation is beneficial in protecting the kidneys from CCl4 toxicity.

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Prophylactic effects of magnesium and vitamin E in rat spinal cord radiation damage: evaluation based on lipid peroxidation levels

Cited by 19 publications

References 37 publications

Magnesium Sulfate Mitigates Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

Magnesium Sulfate Mitigates Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

Inhibitors of the mitochondrial permeability transition reduce ammonia‐induced cell swelling in cultured astrocytes

Effects of MgCl2 supplementation on blood parameters and kidney injury of rats exposed to CCl4

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