Effects of MgCl2 supplementation on blood parameters and kidney injury of rats exposed to CCl4

Mbarki, Sakhria; Dhibi, Sabah; Bouzenna, Hafsia; Elfeki, Abdelfettah; Hfaïedh, Najla

doi:10.1515/biol-2016-0035

Cited by 9 publications

(3 citation statements)

References 65 publications

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“…74 There are various experimental evidences that explained the Mg antioxidant defensive role against various toxic substances. 54,75,76 Therefore, the current research was carried out to explore the cellular antioxidant potency of Mg supplementation on animal models of hepatic and renal toxicity provoked by 2,4-D. It is incredible to observe the beneficial effects of Mg in the present findings against toxicity development.…”

Section: Discussionmentioning

confidence: 99%

Magnesium supplementation ameliorates toxic effects of 2,4-dichlorophenoxyacetic acid in rat model

Shafeeq

Mahboob

2019

Hum Exp Toxicol

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2,4-Dichlorophenoxyacetic acid (2,4-D) is an extensively used herbicide in the field of agriculture, its ever-escalating use induces toxicity, health effects, and environmental impact. Oxidative stress plays a key role in pathogenesis of 2,4-D-induced liver and kidney damage. Magnesium (Mg) is a highly effective antioxidant agent in restoring oxidative damage by directly influencing the metabolic and physiological processes. Therefore, the present study aimed to evaluate Mg role in ameliorating the oxidative damages provoked by 2,4-D in rat model. Male Wistar rats (180–220 g) were distributed into four groups and treated intragastrically for 4 weeks. Group 1: control, group 2: 2,4-D (150 mg/kg body weight/day), group 3: simultaneously treated with 2,4-D (150 mg/kg body weight/day) and Mg supplement (50 mg/kg body weight/day), and group 4: Mg supplement (50 mg/kg body weight/day). Under experimental conditions, plasma hepatic and renal biomarkers, tissue oxidative status, and antioxidant enzymes activities were investigated. Results demonstrated that 2,4-D intoxication caused hepatic and renal impairments as indicated by the significantly increased ( p < 0.001) alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, urea, creatinine, and blood urea nitrogen levels. In addition, 2,4-D caused a significant enhancement ( p < 0.001) in the level of malondialdehyde as well as reduction ( p < 0.001) of the superoxide dismutase, catalase, and glutathione reductase activities in both hepatic and renal tissues. Mg treatment prevented and reversed the toxic variations induced by 2,4-D. In general, these outcomes suggest that Mg may have antioxidant potential and ameliorative effects against 2,4-D provoking hepatic and renal toxicity in rat model.

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Section: Discussionmentioning

confidence: 99%

Magnesium supplementation ameliorates toxic effects of 2,4-dichlorophenoxyacetic acid in rat model

Shafeeq

Mahboob

2019

Hum Exp Toxicol

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“…As revealed in the literature, Mg has a beneficial effect on blood morphology under various pathological and physiological conditions. Magnesium supplementation in rats exposed to carbon tetrachloride inhibited the toxicity of this solvent and prevented changes in blood parameters such as WBC, RBC, Hb, MCHC, and PLT [40]. Oral supplementation with Mg prevents dehydration of erythrocytes and improves the function of the blood cell membrane in patients with sickle cell anemia [41].…”

Section: Discussionmentioning

confidence: 99%

Alleviating Effect of α-Lipoic Acid and Magnesium on Cadmium-Induced Inflammatory Processes, Oxidative Stress and Bone Metabolism Disorders in Wistar Rats

Markiewicz−Górka

Pawlas

Jaremków

et al. 2019

IJERPH

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Cadmium exposure contributes to internal organ dysfunction and the development of chronic diseases. The aim of the study was to assess the alleviating effect of α-lipoic acid and/or magnesium on cadmium-induced oxidative stress and disorders in bone metabolism, kidney and liver function, and hematological and biochemical parameters changes. Male rats were exposed to cadmium (30 mg Cd/kg of feed) for three months. Some animals exposed to Cd were supplemented with magnesium (150 mg Mg/kg of feed) and/or with α-lipoic acid (100 mg/kg body weight, four times a week). Cd intake inhibited body weight gain and lowered hemoglobin concentration, whereas it increased the activities of liver enzymes, as well as the level of oxidative stress, CTX-1 (C-terminal telopeptide of type I collagen, bone resorption marker), and CRP (C-reactive protein, marker of inflammation); it decreased vitamin D3, GSH (reduced glutathione), and the serum urea nitrogen/creatinine index. Mg and/or α-lipoic acid supplementation increased the antioxidant potential, and partially normalized the studied biochemical parameters. The obtained results show that both magnesium and α-lipoic acid decrease oxidative stress and the level of inflammatory marker, as well as normalize bone metabolism and liver and kidney function. Combined intake of α-lipoic acid and magnesium results in reinforcement of the protective effect; especially, it increases antioxidant defense.

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“…The increase in leukocyte count can be explained by the toxic damage caused by the defense system response to the fish or by stressed fish trying to establish homoeostasis balance [31]. The increase in platelet count can be demonstrated by the amount of xenobiotic substance in the body, the adverse effects on the blood-dependent immune system, the decrease in the amount of oxygen in the blood cells, and the response to the spleen [32]. In the case of hypoxia, fishes increase the amount of MCV and MCH of erythrocytes to get through this condition.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Hematological Parameters in two Different Species Trout Exposed to Chlorpyrifos

2019

International Journal of Innovative Studies in Aquatic Biology

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INTRODUCTION Chlorpyrifos (CPF) is intensively used pesticide based on organophosphate insecticide. CPF includes a phosphor thiol functional moiety, has been broadly used in agricultural applies to increase crop yields [1-2]. It was shown that CPF was the pollutants in surface and ground water of many countries. Furthermore, CPF has also been detected in many aquatic ecosystems, including natural and urban streams, rivers and lakes [3]. CPF is very toxic for fish even at low concentrations [4]. Therefore, fish and aquatic organisms and water ecosystems are negatively affecting the balance. There are many studies on the adverse effects of CPF toxicity in fish [5-6-7]. Fish have proved to be good models to evaluate the toxicity and effects of contaminants in previous studies. Rainbow trout and brown trout are an economically important fish species, commonly found in rivers and Dam Lake in Turkey and considered as a potential bio indicator species [8]. Exposure of fish to various chemicals can cause changes in various hematological parameters [9]. Examination of the hematological parameters of organism in studies carried out in order to determine toxic effects is important for achieving correct knowledge [8-10]. Hematology is a science that not only gives information about fish diseases but also determines the effects of nutrition and environmental factors. Fish affects all kinds of stresses, diseases, nutritional deficiencies, toxic substances, changes in water quality and other environmental factors [11]. Hematological parameters are very important diagnosis of diseases. Erythrocyte and leukocyte counts, hemoglobin, hematocrit and platelet counts can easily respond to determining stress caused by environmental pollutants. The measurement of hematological changes in the blood has an important role in predicting the toxic effects of toxic substances [12]. The study of hematology parameters in fishes has been widely used for the detection of physio pathological alterations in different conditions of stress. Consequently, in the present investigation an effort has been made to study the effect of CPF on alterations in hematological parameters of rainbow trout and brown trout to the same stressor were compared. 2. MATERIALS AND METHODS 2.1. Fish Maintenance and Experimental Design Rainbow trout (O. mykiss) and brown trout (S. t. fario) (average weight 160±10 g and mean standard length of 19±2 cm) were supply from Ataturk University, Faculty of Fisheries. The water was Abstract: Environmental pollutants are a major problem for aquaculture. The aim of this study was to evaluate the effects of chlorpyrifos, a pesticide used by agricultural producers in plant production, on some hematological parameters (hemoglobin, hematocrit, erythrocyte, leukocyte, platelet, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) of rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo truttafario). Fish were exposed to CPF concentrations (1 µg/L and 2 µg/L) for periods...

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Effects of MgCl2 supplementation on blood parameters and kidney injury of rats exposed to CCl4

Cited by 9 publications

References 65 publications

Magnesium supplementation ameliorates toxic effects of 2,4-dichlorophenoxyacetic acid in rat model

Magnesium supplementation ameliorates toxic effects of 2,4-dichlorophenoxyacetic acid in rat model

Alleviating Effect of α-Lipoic Acid and Magnesium on Cadmium-Induced Inflammatory Processes, Oxidative Stress and Bone Metabolism Disorders in Wistar Rats

Evaluation of Hematological Parameters in two Different Species Trout Exposed to Chlorpyrifos

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