In vivo platelet deposition on polytetrafluoroethylene coated with fibrin glue containing fibroblast growth factor 1 and heparin in a canine model

Gosselin, Claire; Ren, Dewei; Ellinger, Joan; Greisler, Howard P.

doi:10.1016/s0002-9610(99)80270-0

Cited by 31 publications

(14 citation statements)

References 11 publications

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“…30 Successful use of this sealing technique using fibrin glue confirms the experimental feasibility reported in the 1980s. [9][10][11][12] Also in agreement with earlier experiments 31,32 is the finding that the immediate thrombogenicity of grafts sealed with the fibrin glue matrix was not greater than that of preclotted grafts.…”

Section: Discussionsupporting

confidence: 88%

Sealing of Polyester Prostheses with Autologous Fibrin Glue and Bone Marrow

Cardon

Chakfé

Thaveau

et al. 2000

Annals of Vascular Surgery

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Section: Discussionsupporting

confidence: 88%

Sealing of Polyester Prostheses with Autologous Fibrin Glue and Bone Marrow

Cardon

Chakfé

Thaveau

et al. 2000

Annals of Vascular Surgery

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“…Recently, modified autologous cryoprecipitate has become an important reagent in the ongoing attempts to line the luminal surface of vascular prosthesis with autologous ECs (43)(44)(45). Our preliminary studies have confirmed that ECs remain viable when attached to fibrin meshwork in a threedimensional glue matrix.…”

supporting

confidence: 55%

Role of the endothelium in modulating neointimal formation

Kipshidze

Dangas

Tsapenko

et al. 2004

Journal of the American College of Cardiology

165

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Restenosis at the site of an endoluminal procedure remains a significant problem in the practice of interventional cardiology. We present current data on intimal hyperplasia, which identify the major role of endothelial cells (ECs) in the development of restenosis. Considering endothelial denudation as one of the most important mechanisms contributing to restenosis, we focus more attention on methods of accelerating restoration of endothelial continuity. Prevention of restenosis may be achieved by promoting endothelial regeneration through the use of growth factors, EC seeding, vessel reconstruction with autologous EC/fibrin matrix, and the use of estrogen-loaded stents and stents designed to capture progenitor ECs.

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“…However, the multi‐week cell expansion period and slow proliferation of ECs make this approach unsuitable for emergency treatment. Despite the extensive efforts in these areas, complete endothelialization of synthetic vascular grafts for humans has never been documented22; successful trials resulting in reconstitution of the endothelial layer in synthetic grafts have been performed only in animal models 63, 64. It has been found that EC ingrowth from anastomoses more than 10 mm distant is rare or nonexistant in humans 65.…”

Section: Requirements For Growing Te Vascular Graftsmentioning

confidence: 99%

Biomimetic control of vascular smooth muscle cell morphology and phenotype for functional tissue‐engineered small‐diameter blood vessels

Chan‐Park

Jin

Cao

et al. 2008

J Biomedical Materials Res

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128

131

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Small-diameter blood vessel substitutes are urgently needed for patients requiring replacements of their coronary and below-the-knee vessels and for better arteriovenous dialysis shunts. Circulatory diseases, especially those arising from atherosclerosis, are the predominant cause of mortality and morbidity in the developed world. Current therapies include the use of autologous vessels or synthetic materials as vessel replacements. The limited availability of healthy vessels for use as bypass grafts and the failure of purely synthetic materials in small-diameter sites necessitate the development of a biological substitute. Tissue engineering is such an approach and has achieved promising results, but reconstruction of a functional vascular tunica media, with circumferentially oriented contractile smooth muscle cells (SMCs) and extracellular matrix, appropriate mechanical properties, and vasoactivity has yet to be demonstrated. This review focuses on strategies to effect the switch of SMC phenotype from synthetic to contractile, which is regarded as crucial for the engineering of a functional vascular media. The synthetic SMC phenotype is desired initially for cell proliferation and tissue remodeling, but the contractile phenotype is then necessary for sufficient vasoactivity and inhibition of neointima formation. The factors governing the switch to a more contractile phenotype with in vitro culture are reviewed.

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In vivo platelet deposition on polytetrafluoroethylene coated with fibrin glue containing fibroblast growth factor 1 and heparin in a canine model

Cited by 31 publications

References 11 publications

Sealing of Polyester Prostheses with Autologous Fibrin Glue and Bone Marrow

Sealing of Polyester Prostheses with Autologous Fibrin Glue and Bone Marrow

Role of the endothelium in modulating neointimal formation

Biomimetic control of vascular smooth muscle cell morphology and phenotype for functional tissue‐engineered small‐diameter blood vessels

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